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Publikationer i urvalet

22 träffar

Bibliografisk träff 2019-03-27

Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D<sub>1</sub> Receptor Agonists.

Martini ML, Liu J, Ray C, Yu X, Huang XP, Urs A, Urs N, McCorvy JD, Caron MG, Roth BL, Jin J.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.9b00351

Bibliografisk träff 2012-09-08

Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand.

Clark AH, McCorvy JD, Conley JM, Williams WK, Bekkam M, Watts VJ, Nichols DE.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2012.08.058

Bibliografisk träff 2011-12-03

Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines.

Cueva JP, Chemel BR, Juncosa JI, Lill MA, Watts VJ, Nichols DE.

Eur J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ejmech.2011.11.039

Bibliografisk träff 2011-08-03

Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393.

Clark AH, McCorvy JD, Watts VJ, Nichols DE.

Bioorg Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2011.07.057

Bibliografisk träff 2011-07-14

Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues.

Cueva JP, Gallardo-Godoy A, Juncosa JI, Vidi PA, Lill MA, Watts VJ, Nichols DE.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm200334c

Bibliografisk träff 2009-08-20

Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?

Schulze M, Müller FK, Mason JM, Görls H, Lehmann J, Enzensperger C.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2009.08.028

Bibliografisk träff 2006-11-01

trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist.

Cueva JP, Giorgioni G, Grubbs RA, Chemel BR, Watts VJ, Nichols DE.

J Med Chem · journal article; research support, n.i.h., extramural · DOI 10.1021/jm0604979

Bibliografisk träff 2000-08-01

CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors.

Wilcox RE, Huang WH, Brusniak MY, Wilcox DM, Pearlman RS, Teeter MM, DuRand CJ, Wiens BL, Neve KA.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm990526y

Bibliografisk träff 1999-05-01

trans-2,6-,3,6- and 4,6-diaza-5,6,6a,7,8,12b-hexahydro-benzo[c]phenanthrene-10,11- diols as dopamine agonists.

Gu YG, Bayburt EK, Michaelides MR, Lin CW, Shiosaki K.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(99)00214-0

Bibliografisk träff 1999-03-01

Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane.

Doll MK, Nichols DE, Kilts JD, Prioleau C, Lawler CP, Lewis MM, Mailman RB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm9804533

Bibliografisk träff 1998-10-01

CoMFA-based prediction of agonist affinities at recombinant D1 vs D2 dopamine receptors.

Wilcox RE, Tseng T, Brusniak MY, Ginsburg B, Pearlman RS, Teeter M, DuRand C, Starr S, Neve KA.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm9800292

Bibliografisk träff 1997-07-01

Further definition of the D1 dopamine receptor pharmacophore: synthesis of trans-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphth[2,1-b]azepines as rigid analogues of beta-phenyldopamine.

Negash K, Nichols DE, Watts VJ, Mailman RB.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm970157a

Bibliografisk träff 1997-05-01

Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo.

Michaelides MR, Hong Y, DiDomenico S, Bayburt EK, Asin KE, Britton DR, Lin CW, Shiosaki K.

J Med Chem · journal article · DOI 10.1021/jm970038v

Bibliografisk träff 1996-02-01

Comparative molecular field analysis-based prediction of drug affinities at recombinant D1A dopamine receptors.

Brusniak MY, Pearlman RS, Neve KA, Wilcox RE.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm950447w

Bibliografisk träff 1996-01-01

9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore.

Ghosh D, Snyder SE, Watts VJ, Mailman RB, Nichols DE.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm950707+

Bibliografisk träff 1996-01-01

Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping.

Mottola DM, Laiter S, Watts VJ, Tropsha A, Wyrick SD, Nichols DE, Mailman RB.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm9502100

Bibliografisk träff 1995-09-01

(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431).

Michaelides MR, Hong Y, DiDomenico S, Asin KE, Britton DR, Lin CW, Williams M, Shiosaki K.

J Med Chem · journal article · DOI 10.1021/jm00018a002

Bibliografisk träff 1995-08-01

Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors.

Knoerzer TA, Watts VJ, Nichols DE, Mailman RB.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00016a009

Bibliografisk träff 1995-06-01

Synthesis and evaluation of 6,7-dihydroxy-2,3,4,8,9,13b-hexahydro-1H- benzo[6,7]cyclohepta[1,2,3-ef][3]benzazepine, 6,7-dihydroxy- 1,2,3,4,8,12b-hexahydroanthr[10,4a,4-cd]azepine, and 10-(aminomethyl)-9,10- dihydro-1,2-dihydroxyanthracene as conformationally restricted analogs of beta-phenyldopamine.

Snyder SE, Aviles-Garay FA, Chakraborti R, Nichols DE, Watts VJ, Mailman RB.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00013a015

Bibliografisk träff 1995-01-01

Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands.

Brewster WK, Nichols DE, Watts VJ, Riggs RM, Mottola D, Mailman RB.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00002a013

Bibliografisk träff 1994-07-01

Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist.

Knoerzer TA, Nichols DE, Brewster WK, Watts VJ, Mottola D, Mailman RB.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00041a025

Bibliografisk träff 1990-06-01

trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist.

Brewster WK, Nichols DE, Riggs RM, Mottola DM, Lovenberg TW, Lewis MH, Mailman RB.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00168a034