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Publikationer i urvalet

26 träffar

Bibliografisk träff 2024-02-16

Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents.

Zaraei SO, Dohle W, Anbar HS, El-Gamal R, Leblond B, Foster PA, Al-Tel TH, Potter BVL, El-Gamal MI.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2024.117645

Bibliografisk träff 2023-06-27

Potent Dual Inhibitors of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for <i>In Vivo</i> Proof-of-Principle Studies in an Endometriosis Mouse Model.

Salah M, Salah M, Tahoun M, Rudzitis-Auth J, Stotz L, van Koppen CJ, Laschke MW, Abdelsamie AS, Frotscher M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.3c00571

Bibliografisk träff 2022-08-22

Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis.

Mohamed A, Salah M, Tahoun M, Hawner M, Abdelsamie AS, Frotscher M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.2c00589

Bibliografisk träff 2022-08-08

An overview on Estrogen receptors signaling and its ligands in breast cancer.

Khan MZI, Uzair M, Nazli A, Chen JZ.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2022.114658

Bibliografisk träff 2022-03-02

Development of Sulfamoylated 4-(1-Phenyl-1<i>H</i>-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer.

Biernacki K, Ciupak O, Daśko M, Rachon J, Kozak W, Rak J, Kubiński K, Masłyk M, Martyna A, Śliwka-Kaszyńska M, Wietrzyk J, Świtalska M, Nocentini A, Supuran CT, Demkowicz S.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.1c02220

Bibliografisk träff 2021-07-27

Rational Multitargeted Drug Design Strategy from the Perspective of a Medicinal Chemist.

Li X, Li X, Liu F, Li S, Shi D.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.1c00683

Bibliografisk träff 2021-06-07

New Protocol-Guided Exploitation of a Lysosomal Sulfatase Inhibitor to Suppress Cell Growth in Glioblastoma Multiforme.

Zhang MM, Jia Y, Li P, Qiao Y, Qiao Y, Han KL.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c00559

Bibliografisk träff 2020-03-03

A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation.

El-Gamal MI, Zaraei SO, Foster PA, Anbar HS, El-Gamal R, El-Awady R, Potter BVL.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2020.115406

Bibliografisk träff 2017-04-27

First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases.

Salah M, Abdelsamie AS, Frotscher M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.7b00062

Bibliografisk träff 2016-04-22

Design, synthesis, and biological evaluation of new arylamide derivatives possessing sulfonate or sulfamate moieties as steroid sulfatase enzyme inhibitors.

El-Gamal MI, Semreen MH, Foster PA, Potter BV.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.bmc.2016.04.040

Bibliografisk träff 2016-02-24

Sulfatase inhibitors for recidivist breast cancer treatment: A chemical review.

Shah R, Singh J, Singh D, Jaggi AS, Singh N.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2016.02.054

Bibliografisk träff 2014-02-28

Design and synthesis of silicon-containing steroid sulfatase inhibitors possessing pro-estrogen antagonistic character.

Kajita D, Nakamura M, Matsumoto Y, Makishima M, Hashimoto Y.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2014.02.025

Bibliografisk träff 2014-01-11

Synthesis, structure-activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents.

Basanagouda M, Jambagi VB, Barigidad NN, Laxmeshwar SS, Devaru V, Narayanachar.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2013.12.061

Bibliografisk träff 2013-12-10

Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages.

Jang HL, El-Gamal MI, Choi HE, Choi HY, Lee KT, Oh CH.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2013.12.018

Bibliografisk träff 2012-01-05

17β-Arylsulfonamides of 17β-aminoestra-1,3,5(10)-trien-3-ol as highly potent inhibitors of steroid sulfatase.

Mostafa YA, Taylor SD.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2011.12.036

Bibliografisk träff 2011-08-30

Inhibition of steroid sulfatase with 4-substituted estrone and estradiol derivatives.

Phan CM, Liu Y, Kim BM, Mostafa Y, Taylor SD.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2011.08.046

Bibliografisk träff 2010-03-01

Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template.

Woo LW, Jackson T, Putey A, Cozier G, Leonard P, Acharya KR, Chander SK, Purohit A, Reed MJ, Potter BV.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm901705h

Bibliografisk träff 2008-07-05

Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.

Temperini C, Innocenti A, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2008.06.105

Bibliografisk träff 2008-07-01

Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity.

Wood PM, Woo LW, Labrosse JR, Trusselle MN, Abbate S, Longhi G, Castiglioni E, Lebon F, Purohit A, Reed MJ, Potter BV.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm800168s

Bibliografisk träff 2007-06-20

Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase.

Jütten P, Schumann W, Härtl A, Dahse HM, Gräfe U.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0611657

Bibliografisk träff 2007-06-20

Dual aromatase-steroid sulfatase inhibitors.

Woo LW, Bubert C, Sutcliffe OB, Smith A, Chander SK, Mahon MF, Purohit A, Reed MJ, Potter BV.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm061462b

Bibliografisk träff 2004-02-01

Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid.

Patel CK, Owen CP, Ahmed S.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2003.11.067

Bibliografisk träff 2003-07-01

First dual aromatase-steroid sulfatase inhibitors.

Woo LW, Sutcliffe OB, Bubert C, Grasso A, Chander SK, Purohit A, Reed MJ, Potter BV.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm034033b

Bibliografisk träff 2003-03-01

Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II.

Vicker N, Ho Y, Robinson J, Woo LL, Purohit A, Reed MJ, Potter BV.

Bioorg Med Chem Lett · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(03)00009-x

Bibliografisk träff 2002-05-01

Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES).

Ahmed S, James K, Owen CP, Patel CK.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(02)00170-1

Bibliografisk träff 2001-12-01

Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism.

Ahmed S, James K, Owen CP, Patel CK, Patel MB.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(01)00607-2