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Publikationer i urvalet

11 träffar

Bibliografisk träff 2024-06-04

Identification of sulfonylpyrimidines as novel selective aldosterone synthase (CYP11B2) inhibitors.

Meguro M, Miyauchi S, Kanao-Arisumi Y, Naito S, Suzuki K, Inoue S, Yamada K, Homma T, Chiba K, Nara F, Furuzono S.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2024.117775

Bibliografisk träff 2023-10-05

Fluorinated aldosterone synthase (CYP11B2)-inhibitors for differential diagnosis between bilateral and unilateral conditions of primary aldosteronism.

Maier P, Heinze B, Gabor S, Reese S, Hahner S, Schirbel A.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2023.129501

Bibliografisk träff 2022-08-17

Design, Synthesis, and Biological Evaluations of Pyridyl 4,5,6,7-Tetrahydro-4,7-Methanobenzo[<i>d</i>]isoxazoles as Potent and Selective Inhibitors of 11β-Hydroxylase.

Yin L, Pan Y, Xue Y, Chen X, You T, Huang J, Xu Q, Hu Q.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.2c01037

Bibliografisk träff 2017-12-08

Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.

Meyers K, Cogan DA, Burke J, Arenas R, Balestra M, Brown NF, Chen Z, Cerny MA, Clifford HE, Colombo F, Fader L, Frederick KS, Guo X, Goldberg D, Hornberger KR, Kugler S, Lord J, Marshall DR, Moss N, Parmentier JH, Richman JR, Schmenk J, Weldon SM, Yu M, Zhang M.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2017.12.015

Bibliografisk träff 2017-03-21

4-Anilino-pyrimidine, novel aldosterone synthase (CYP11B2) inhibitors bearing pyrimidine structures.

Meguro M, Miyauchi S, Kanao Y, Naito S, Suzuki K, Inoue S, Yamada K, Homma T, Chiba K, Nara F, Furuzono S.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2017.03.034

Bibliografisk träff 2014-01-24

Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases.

Hu Q, Yin L, Hartmann RW.

J Med Chem · journal article · DOI 10.1021/jm401430e

Bibliografisk träff 2013-10-17

Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.

Meredith EL, Ksander G, Monovich LG, Papillon JP, Liu Q, Miranda K, Morris P, Rao C, Burgis R, Capparelli M, Hu QY, Singh A, Rigel DF, Jeng AY, Beil M, Fu F, Hu CW, LaSala D.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml400324c

Bibliografisk träff 2010-06-19

The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.

Adams CM, Hu CW, Jeng AY, Karki R, Ksander G, Lasala D, Leung-Chu J, Liang G, Liu Q, Meredith E, Rao C, Rigel DF, Shi J, Smith S, Springer C, Zhang C.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2010.06.086

Bibliografisk träff 2010-02-01

Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).

Roumen L, Peeters JW, Emmen JM, Beugels IP, Custers EM, de Gooyer M, Plate R, Pieterse K, Hilbers PA, Smits JF, Vekemans JA, Leysen D, Ottenheijm HC, Janssen HM, Hermans JJ.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm901356d

Bibliografisk träff 2005-11-01

Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach.

Cavalli A, Bisi A, Bertucci C, Rosini C, Paluszcak A, Gobbi S, Giorgio E, Rampa A, Belluti F, Piazzi L, Valenti P, Hartmann RW, Recanatini M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm058042r

Bibliografisk träff 1993-05-01

Aromatase inhibitors: synthesis, biological activity, and binding mode of azole-type compounds.

Furet P, Batzl C, Bhatnagar A, Francotte E, Rihs G, Lang M.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00062a012