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Publikationer i urvalet

27 träffar

Bibliografisk träff 2022-04-27

Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents.

Zorbaz T, Malinak D, Hofmanova T, Maraković N, Žunec S, Hrvat NM, Andrys R, Psotka M, Zandona A, Svobodova J, Prchal L, Fingler S, Katalinić M, Kovarik Z, Musilek K.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114377

Bibliografisk träff 2022-03-07

A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning.

Da Silva O, Probst N, Landry C, Hanak AS, Warnault P, Coisne C, Calas AG, Gosselet F, Courageux C, Gastellier AJ, Trancart M, Baati R, Dehouck MP, Jean L, Nachon F, Renard PY, Dias J.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.1c01748

Bibliografisk träff 2017-11-13

Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase.

de Koning MC, Joosen MJA, Worek F, Nachon F, van Grol M, Klaassen SD, Alkema DPW, Wille T, de Bruijn HM.

J Med Chem · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/acs.jmedchem.7b01083

Bibliografisk träff 2016-07-06

Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE).

Karade HN, Raviraju G, Acharya BN, Valiveti AK, Bhalerao U, Acharya J.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2016.07.005

Bibliografisk träff 2014-10-22

New efficient imidazolium aldoxime reactivators for nerve agent-inhibited acetylcholinesterase.

Wei Z, Liu YQ, Zhou XB, Luo Y, Huang CQ, Wang YA, Zheng ZB, Li S.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2014.10.055

Bibliografisk träff 2014-03-25

Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE).

Karade HN, Valiveti AK, Acharya J, Kaushik MP.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2014.03.023

Bibliografisk träff 2014-02-07

Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification.

Sit RK, Fokin VV, Amitai G, Sharpless KB, Taylor P, Radić Z.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm401650z

Bibliografisk träff 2012-11-26

Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.

Mercey G, Renou J, Verdelet T, Kliachyna M, Baati R, Gillon E, Arboléas M, Loiodice M, Nachon F, Jean L, Renard PY.

J Med Chem · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm3015519

Bibliografisk träff 2011-06-12

Synthesis and in vitro evaluation of xylene linked carbamoyl bis-pyridinium monooximes as reactivators of organophosphorus (OP) inhibited electric eel acetylcholinesterase (AChE).

Acharya J, Rana H, Kaushik MP.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2011.05.064

Bibliografisk träff 2011-04-11

Amidine-oximes: reactivators for organophosphate exposure.

Kalisiak J, Ralph EC, Zhang J, Cashman JR.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm200054r

Bibliografisk träff 2010-12-16

Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.

Musilek K, Komloova M, Holas O, Horova A, Pohanka M, Gunn-Moore F, Dohnal V, Dolezal M, Dolezal M, Kuca K.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2010.12.021

Bibliografisk träff 2010-11-16

Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128.

Musilek K, Roder J, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Opletalova V, Kuca K, Jung YS.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2010.11.051

Bibliografisk träff 2008-12-24

Reactivation potency of fluorinated pyridinium oximes for acetylcholinesterases inhibited by paraoxon organophosphorus agent.

Jeong HC, Kang NS, Park NJ, Yum EK, Jung YS.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2008.12.070

Bibliografisk träff 2008-07-20

Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase.

Musilek K, Kucera J, Jun D, Dohnal V, Opletalova V, Kuca K.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2008.07.036

Bibliografisk träff 2008-05-15

Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.

Butini S, Campiani G, Borriello M, Gemma S, Panico A, Persico M, Catalanotti B, Ros S, Brindisi M, Agnusdei M, Fiorini I, Nacci V, Novellino E, Belinskaya T, Saxena A, Fattorusso C.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm701253t

Bibliografisk träff 2008-03-07

Synthesis and evaluation of novel bis-pyridinium oximes as reactivators of DFP-inhibited acetylcholinesterase.

Acharya J, Gupta AK, Dubey DK, Raza SK.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2008.02.029

Bibliografisk träff 2008-03-05

In-vitro regeneration of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing xylene linker.

Acharya J, Gupta AK, Mazumder A, Dubey DK.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2008.02.020

Bibliografisk träff 2007-10-09

Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203).

Musilek K, Jun D, Cabal J, Kassa J, Gunn-Moore F, Kuca K.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm070653r

Bibliografisk träff 2007-08-10

Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase.

Musilek K, Holas O, Jun D, Dohnal V, Gunn-Moore F, Opletalova V, Dolezal M, Dolezal M, Kuca K.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.08.002

Bibliografisk träff 2007-03-13

Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.

Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Opletalova V, Dolezal M, Dolezal M.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2007.03.025

Bibliografisk träff 2006-08-24

Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.

Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Dolezal M, Dolezal M.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2006.08.011

Bibliografisk träff 2005-11-08

Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.

Musilek K, Kuca K, Jun D, Dohnal V, Dolezal M, Dolezal M.

Bioorg Med Chem Lett · research support, non-u.s. gov't; evaluation study; journal article · DOI 10.1016/j.bmcl.2005.10.059

Bibliografisk träff 2003-10-01

Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase.

Kuca K, Bielavský J, Cabal J, Kassa J.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(03)00751-0

Bibliografisk träff 1989-02-01

Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.

Bedford CD, Harris RN, Howd RA, Goff DA, Koolpe GA, Petesch M, Miller A, Nolen HW, Musallam HA, Pick RO.

J Med Chem · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00122a034

Bibliografisk träff 1986-09-01

Nonquaternary cholinesterase reactivators. 4. Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro.

Bedford CD, Miura M, Bottaro JC, Howd RA, Nolen HW.

J Med Chem · comparative study; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00159a021

Bibliografisk träff 1984-11-01

Structure-activity relationships for reactivators of organophosphorus-inhibited acetylcholinesterase: quaternary salts of 2-[(hydroxyimino)methyl]imidazole.

Bedford CD, Harris RN, Howd RA, Miller A, Nolen HW, Kenley RA.

J Med Chem · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00377a010

Bibliografisk träff 1979-11-01

Antidotes or organophosphate poisoning. 2. Thiadiazole-5-carboxaldoximes.

Benschop HP, Van den Berg GR, Van Hooidonk C, De Jong LP, Kientz CE, Berends F, Kepner LA, Meeter E, Visser RP.

J Med Chem · journal article · DOI 10.1021/jm00197a006