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Publikationer i urvalet

7 träffar

Bibliografisk träff 2024-08-29

Selective Degradation of MLK3 by a Novel CEP1347-VHL-02 PROTAC Compound Limits the Oncogenic Potential of TNBC.

Karpińska K, Mehlich D, Sabbasani VR, Łomiak M, Torres-Ayuso P, Wróbel K, Truong VN, Serwa R, Swenson RE, Brognard J, Marusiak AA.

J Med Chem · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.4c00577

Bibliografisk träff 2024-02-10

Design, synthesis of new 3H-imidazo[4,5-b]pyridine derivatives and evaluation of their inhibitory properties as mixed lineage kinase 3 inhibitors.

Yoon HR, Balupuri A, Lee J, Lee C, Son DH, Jeoung RG, Kim KA, Choi S, Kang NS.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2024.129652

Bibliografisk träff 2023-05-24

The emerging role of mixed lineage kinase 3 (MLK3) and its potential as a target for neurodegenerative diseases therapies.

Moreno R, Recio J, Barber S, Gil C, Martinez A.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2023.115511

Bibliografisk träff 2018-06-04

Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration.

Siu M, Sengupta Ghosh A, Lewcock JW.

J Med Chem · review; journal article · DOI 10.1021/acs.jmedchem.8b00370

Bibliografisk träff 2013-10-03

Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.

Goodfellow VS, Loweth CJ, Ravula SB, Wiemann T, Nguyen T, Xu Y, Todd DE, Sheppard D, Pollack S, Polesskaya O, Marker DF, Dewhurst S, Gelbard HA.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm401094t

Bibliografisk träff 2008-08-21

Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models.

Hudkins RL, Diebold JL, Tao M, Josef KA, Park CH, Angeles TS, Aimone LD, Husten J, Ator MA, Meyer SL, Holskin BP, Durkin JT, Fedorov AA, Fedorov EV, Almo SC, Mathiasen JR, Bozyczko-Coyne D, Saporito MS, Scott RW, Mallamo JP.

J Med Chem · journal article · DOI 10.1021/jm8005838

Bibliografisk träff 2002-01-01

Mixed lineage kinase activity of indolocarbazole analogues.

Murakata C, Kaneko M, Gessner G, Angeles TS, Ator MA, O'Kane TM, McKenna BA, Thomas BA, Mathiasen JR, Saporito MS, Bozyczko-Coyne D, Hudkins RL.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(01)00690-4