Structure-activity relationship study of new carbazole sulfonamide derivatives as anticancer agents with dual-target mechanism.
Liu Y, Zhang J, Tian J, Wang C, Wang T, Gong J, Hu L.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2024.116509 PUBLIKATIONSREGISTRET
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J Nat Prod · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jnatprod.9b00773Synthesis and structure-activity relationship study of water-soluble carbazole sulfonamide derivatives as new anticancer agents.
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J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.9b00551Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents.
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J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.8b01391A class of novel tubulin polymerization inhibitors exert effective anti-tumor activity via mitotic catastrophe.
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Bueno O, Tobajas G, Quesada E, Estévez-Gallego J, Noppen S, Camarasa MJ, Díaz JF, Liekens S, Priego EM, Pérez-Pérez MJ.
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J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.7b00480Tubulin-binding dibenz[c,e]oxepines: Part 2. Structural variation and biological evaluation as tumour vasculature disrupting agents.
Rossington SB, Hadfield JA, Shnyder SD, Wallace TW, Williams KJ.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2017.01.027Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4.
Brown AW, Fisher M, Tozer GM, Kanthou C, Harrity JP.
J Med Chem · journal article · DOI 10.1021/acs.jmedchem.6b01128Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies.
Semenov VV, Lichitsky BV, Komogortsev AN, Dudinov AA, Krayushkin MM, Konyushkin LD, Atamanenko OP, Karmanova IB, Strelenko YA, Shor B, Semenova MN, Kiselyov AS.
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J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jnatprod.6b00173Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin.
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J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.5b00155Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2.
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Romagnoli R, Baraldi PG, Salvador MK, Prencipe F, Bertolasi V, Cancellieri M, Brancale A, Hamel E, Castagliuolo I, Consolaro F, Porcù E, Basso G, Viola G.
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Demchuk DV, Samet AV, Chernysheva NB, Ushkarov VI, Stashina GA, Konyushkin LD, Raihstat MM, Firgang SI, Philchenkov AA, Zavelevich MP, Kuiava LM, Chekhun VF, Blokhin DY, Kiselyov AS, Semenova MN, Semenov VV.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2013.12.015Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents.
Romagnoli R, Baraldi PG, Lopez-Cara C, Preti D, Aghazadeh Tabrizi M, Balzarini J, Bassetto M, Brancale A, Fu XH, Gao Y, Li J, Zhang SZ, Hamel E, Bortolozzi R, Basso G, Viola G.
J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm4013938Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.
Hadimani MB, Macdonough MT, Ghatak A, Strecker TE, Lopez R, Sriram M, Nguyen BL, Hall JJ, Kessler RJ, Shirali AR, Liu L, Garner CM, Pettit GR, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG.
J Nat Prod · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/np400374wSynthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents.
Tanpure RP, George CS, Strecker TE, Devkota L, Tidmore JK, Lin CM, Herdman CA, Macdonough MT, Sriram M, Chaplin DJ, Trawick ML, Pinney KG.
Bioorg Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2013.08.035Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents.
Romagnoli R, Baraldi PG, Kimatrai Salvador M, Preti D, Aghazadeh Tabrizi M, Bassetto M, Brancale A, Hamel E, Castagliuolo I, Bortolozzi R, Basso G, Viola G.
J Med Chem · research-article; journal article · DOI 10.1021/jm400043dAntineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs.
Pettit GR, Rosenberg HJ, Dixon R, Knight JC, Hamel E, Chapuis JC, Pettit RK, Hogan F, Sumner B, Ain KB, Trickey-Platt B.
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