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Publikationer i urvalet

17 träffar

Bibliografisk träff 2008-11-05

Parallel synthesis, molecular modelling and further structure-activity relationship studies of new acylthiocarbamates as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Spallarossa A, Cesarini S, Ranise A, Schenone S, Bruno O, Borassi A, La Colla P, Pezzullo M, Sanna G, Collu G, Secci B, Loddo R.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2008.10.032

Bibliografisk träff 2008-09-30

Novel modifications in the series of O-(2-phthalimidoethyl)-N-substituted thiocarbamates and their ring-opened congeners as non-nucleoside HIV-1 reverse transcriptase inhibitors.

Spallarossa A, Cesarini S, Ranise A, Bruno O, Schenone S, La Colla P, Collu G, Sanna G, Secci B, Loddo R.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2008.09.024

Bibliografisk träff 2008-05-07

Parallel one-pot synthesis and structure-activity relationship study of symmetric formimidoester disulfides as a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Cesarini S, Spallarossa A, Ranise A, Schenone S, Bruno O, La Colla P, Casula L, Collu G, Sanna G, Loddo R.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2008.05.010

Bibliografisk träff 2007-12-25

Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Parallel synthesis, molecular modelling and structure-activity relationship studies on O-[2-(hetero)arylethyl]-N-phenylthiocarbamates.

Cesarini S, Spallarossa A, Ranise A, Fossa P, La Colla P, Sanna G, Collu G, Loddo R.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.12.050

Bibliografisk träff 2007-12-25

Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: Parallel synthesis, molecular modelling and structure-activity relationship studies on analogues of O-(2-phenylethyl)-N-phenylthiocarbamate.

Cesarini S, Spallarossa A, Ranise A, Bruno O, La Colla P, Secci B, Collu G, Loddo R.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.12.046

Bibliografisk träff 2007-02-04

Predicting anti-HIV activity of PETT derivatives: CoMFA approach.

Ravichandran V, Agrawal RK.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2007.01.103

Bibliografisk träff 2005-04-01

Hierarchical database screenings for HIV-1 reverse transcriptase using a pharmacophore model, rigid docking, solvation docking, and MM-PB/SA.

Wang J, Kang X, Kuntz ID, Kollman PA.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm049606e

Bibliografisk träff 2003-02-01

Design, synthesis, SAR, and molecular modeling studies of acylthiocarbamates: a novel series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors structurally related to phenethylthiazolylthiourea derivatives.

Ranise A, Spallarossa A, Schenone S, Bruno O, Bondavalli F, Vargiu L, Marceddu T, Mura M, La Colla P, Pani A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0209984

Bibliografisk träff 2002-07-01

Prediction of activity for nonnucleoside inhibitors with HIV-1 reverse transcriptase based on Monte Carlo simulations.

Rizzo RC, Udier-Blagović M, Wang DP, Watkins EK, Kroeger Smith MB, Smith RH, Tirado-Rives J, Jorgensen WL.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm010580q

Bibliografisk träff 2000-09-01

Stereochemistry of halopyridyl and thiazolyl thiourea compounds is a major determinant of their potency as nonnucleoside inhibitors of HIV-1 reverse transcriptase.

Venkatachalam TK, Sudbeck EA, Mao C, Uckun FM.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(00)00398-x

Bibliografisk träff 1999-12-01

N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1.

Uckun FM, Pendergrass S, Maher D, Zhu D, Tuel-Ahlgren L, Mao C, Venkatachalam TK.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(99)00624-1

Bibliografisk träff 1999-09-01

N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea and N'-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-chloropyridyl)]-thiourea as potent inhibitors of multidrug-resistant human immunodeficiency virus-1.

Uckun FM, Mao C, Pendergrass S, Maher D, Zhu D, Tuel-Ahlgren L, Venkatachalam TK.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(99)00460-6

Bibliografisk träff 1999-06-01

Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus.

Mao C, Sudbeck EA, Venkatachalam TK, Uckun FM.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(99)00235-8

Bibliografisk träff 1998-08-01

Structure-based design of N-[2-(1-piperidinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Mao C, Vig R, Venkatachalam TK, Sudbeck EA, Uckun FM.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(98)00384-9

Bibliografisk träff 1998-06-01

Synthesis and anti-HIV activities of urea-PETT analogs belonging to a new class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Sahlberg C, Noréen R, Engelhardt P, Högberg M, Kangasmetsä J, Vrang L, Zhang H.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(98)00249-2

Bibliografisk träff 1996-10-01

Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.

Cantrell AS, Engelhardt P, Högberg M, Jaskunas SR, Johansson NG, Jordan CL, Kangasmetsä J, Kinnick MD, Lind P, Morin JM, Muesing MA, Noreén R, Oberg B, Pranc P, Sahlberg C, Ternansky RJ, Vasileff RT, Vrang L, West SJ, Zhang H.

J Med Chem · journal article · DOI 10.1021/jm950639r

Bibliografisk träff 1995-12-01

Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.

Bell FW, Cantrell AS, Högberg M, Jaskunas SR, Johansson NG, Jordan CL, Kinnick MD, Lind P, Morin JM, Noréen R.

J Med Chem · journal article · DOI 10.1021/jm00025a010