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Publikationer i urvalet

9 träffar

Bibliografisk träff 2008-11-17

Multiple-dose pharmacokinetic behavior of elvucitabine, a nucleoside reverse transcriptase inhibitor, administered over 21 days with lopinavir-ritonavir in human immunodeficiency virus type 1-infected subjects.

Colucci P, Pottage JC, Robison H, Turgeon J, Schürmann D, Hoepelman IM, Ducharme MP.

Antimicrob Agents Chemother · research-article; journal article · DOI 10.1128/aac.00907-08

Bibliografisk träff 2008-11-17

Effect of a single dose of ritonavir on the pharmacokinetic behavior of elvucitabine, a nucleoside reverse transcriptase inhibitor, administered in healthy volunteers.

Colucci P, Pottage JC, Robison H, Turgeon J, Ducharme MP.

Antimicrob Agents Chemother · comparative study; research-article; randomized controlled trial; journal article · DOI 10.1128/aac.00905-08

Bibliografisk träff 2004-05-01

2('),3(')-didehydro-2('),3(')-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditions.

Shi J, Ray AS, Mathew JS, Anderson KS, Chu CK, Schinazi RF.

Bioorg Med Chem Lett · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/j.bmcl.2004.02.031

Bibliografisk träff 2003-06-01

The role of 2',3'-unsaturation on the antiviral activity of anti-HIV nucleosides against 3TC-resistant mutant (M184V).

Choo H, Chong Y, Chu CK.

Bioorg Med Chem Lett · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/s0960-894x(03)00330-5

Bibliografisk träff 1999-03-01

Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.

Shi J, McAtee JJ, Schlueter Wirtz S, Tharnish P, Juodawlkis A, Liotta DC, Schinazi RF.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm980510s

Bibliografisk träff 1998-11-01

Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C.

Chen SH, Lin S, King I, Spinka T, Dutschman GE, Gullen EA, Cheng YC, Doyle TW.

Bioorg Med Chem Lett · comparative study; journal article · DOI 10.1016/s0960-894x(98)00599-x

Bibliografisk träff 1998-07-01

Synthesis and biological evaluation of a series of 2'-fluorinated-2',3'-dideoxy-2',3'-didehydro-(L)-nucleosides.

Chen SH, Wang Q, Mao J, King I, Dutschman GE, Gullen EA, Cheng YC, Doyle TW.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(98)00277-7

Bibliografisk träff 1998-01-01

Bis-S-acyl-2-thioethyl (SATE)-bearing monophosphate prodrug of beta-L-FD4C as potent anti-HBV agent.

Li X, Carmichael E, Feng M, King I, Doyle TW, Chen SH.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(97)10178-0

Bibliografisk träff 1996-04-01

Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro.

Lin TS, Luo MZ, Liu MC, Zhu YL, Gullen E, Dutschman GE, Cheng YC.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm950836q