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Publikationer i urvalet

12 träffar

Bibliografisk träff 2005-02-01

CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist.

Baron BM, Cregge RJ, Farr RA, Friedrich D, Gross RS, Harrison BL, Janowick DA, Matthews D, McCloskey TC, Meikrantz S, Nyce PL, Vaz R, Metz WA.

J Med Chem · journal article · DOI 10.1021/jm0491849

Bibliografisk träff 2003-04-01

CoMFA and homology-based models of the glycine binding site of N-methyl-d-aspartate receptor.

Tikhonova IG, Baskin II, Palyulin VA, Zefirov NS.

J Med Chem · journal article · DOI 10.1021/jm0210156

Bibliografisk träff 2001-06-01

Structure-activity relationships of 1,4-dihydro-(1H,4H)-quinoxaline-2,3-diones as N-methyl-D-aspartate (glycine site) receptor antagonists. 1. Heterocyclic substituted 5-alkyl derivatives.

Fray MJ, Bull DJ, Carr CL, Gautier EC, Mowbray CE, Stobie A.

J Med Chem · journal article · DOI 10.1021/jm001124p

Bibliografisk träff 2000-06-01

Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity.

Jimonet P, Ribeill Y, Bohme GA, Boireau A, Chevé M, Damour D, Doble A, Genevois-Borella A, Herman F, Imperato A, Le Guern S, Manfré F, Pratt J, Randle JC, Stutzmann JM, Mignani S.

J Med Chem · journal article · DOI 10.1021/jm990957g

Bibliografisk träff 1999-09-01

Substituted analogues of GV150526 as potent glycine binding site antagonists in animal models of cerebral ischemia.

Di Fabio R, Conti N, De Magistris E, Feriani A, Provera S, Sabbatini FM, Reggiani A, Rovatti L, Barnaby RJ.

J Med Chem · journal article · DOI 10.1021/jm980576n

Bibliografisk träff 1998-01-01

5-Aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists.

Auberson YP, Acklin P, Allgeier H, Biollaz M, Bischoff S, Ofner S, Veenstra SJ.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(97)10187-1

Bibliografisk träff 1997-12-01

Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists.

Rowley M, Kulagowski JJ, Watt AP, Rathbone D, Stevenson GI, Carling RW, Baker R, Marshall GR, Kemp JA, Foster AC, Grimwood S, Hargreaves R, Hurley C, Saywell KL, Tricklebank MD, Leeson PD.

J Med Chem · journal article · DOI 10.1021/jm970417o

Bibliografisk träff 1997-10-01

5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors.

Cai SX, Huang JC, Espitia SA, Tran M, Ilyin VI, Hawkinson JE, Woodward RM, Weber E, Keana JF.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm970396y

Bibliografisk träff 1997-03-01

Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site.

Di Fabio R, Capelli AM, Conti N, Cugola A, Donati D, Feriani A, Gastaldi P, Gaviraghi G, Hewkin CT, Micheli F, Missio A, Mugnaini M, Pecunioso A, Quaglia AM, Ratti E, Rossi L, Tedesco G, Trist DG, Reggiani A.

J Med Chem · journal article · DOI 10.1021/jm960644a

Bibliografisk träff 1997-02-01

Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor.

Cai SX, Kher SM, Zhou ZL, Ilyin V, Espitia SA, Tran M, Hawkinson JE, Woodward RM, Weber E, Keana JF.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm960654b

Bibliografisk träff 1995-10-01

Synthesis and structure-activity relationships of substituted 1,4-dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors.

Keana JF, Kher SM, Cai SX, Dinsmore CM, Glenn AG, Guastella J, Huang JC, Ilyin V, Lü Y, Mouser PL.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00022a003

Bibliografisk träff 1994-11-01

The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.

Leeson PD, Iversen LL.

J Med Chem · review; journal article · DOI 10.1021/jm00050a001