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Publikationer i urvalet

11 träffar

Bibliografisk träff 2010-05-01

Thousands of chemical starting points for antimalarial lead identification.

Gamo FJ, Sanz LM, Vidal J, de Cozar C, Alvarez E, Lavandera JL, Vanderwall DE, Green DV, Kumar V, Hasan S, Brown JR, Peishoff CE, Cardon LR, Garcia-Bustos JF.

Nature · research support, non-u.s. gov't; journal article · DOI 10.1038/nature09107

Bibliografisk träff 2008-08-26

Design, synthesis, and docking studies of novel benzopyrone derivatives as H(1)-antihistaminic agents.

Farag NA, Mohamed SR, Soliman GA.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2008.08.039

Bibliografisk träff 1997-09-01

Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.

Robson C, Meek MA, Grunwaldt JD, Lambert PA, Queener SF, Schmidt D, Griffin RJ.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm970055k

Bibliografisk träff 1996-02-01

High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.

Kuyper LF, Baccanari DP, Jones ML, Hunter RN, Tansik RL, Joyner SS, Boytos CM, Rudolph SK, Knick V, Wilson HR, Caddell JM, Friedman HS, Comley JC, Stables JN.

J Med Chem · comparative study; journal article · DOI 10.1021/jm9505122

Bibliografisk träff 1990-07-01

Structure-activity relationships of antineoplastic agents in multidrug resistance.

Selassie CD, Hansch C, Khwaja TA.

J Med Chem · journal article · DOI 10.1021/jm00169a014

Bibliografisk träff 1989-11-01

Structural studies on bioactive compounds. 8. Synthesis, crystal structure, and biological properties of a new series of 2,4-diamino-5-aryl-6-ethylpyrimidine dihydrofolate reductase inhibitors with in vivo activity against a methotrexate-resistant tumor cell line.

Griffin RJ, Meek MA, Schwalbe CH, Stevens MF.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00131a009

Bibliografisk träff 1985-12-01

Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate.

Coats EA, Genther CS, Selassie CD, Strong CD, Hansch C.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00150a026

Bibliografisk träff 1984-12-01

Functional group contributions to drug-receptor interactions.

Andrews PR, Craik DJ, Martin JL.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00378a021

Bibliografisk träff 1984-03-01

Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.

Selassie CD, Hansch C, Khwaja TA, Dias CB, Pentecost S.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00369a019

Bibliografisk träff 1980-06-01

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability.

Levin VA.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00180a022

Bibliografisk träff 1980-03-01

Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine.

Grivsky EM, Lee S, Sigel CW, Duch DS, Nichol CA.

J Med Chem · journal article · DOI 10.1021/jm00177a025