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Publikationer i urvalet

10 träffar

Bibliografisk träff 2014-01-16

Development of [(3)H]2-Carboxy-4,6-dichloro-1H-indole-3-propionic Acid ([(3)H]PSB-12150): A Useful Tool for Studying GPR17.

Köse M, Ritter K, Thiemke K, Gillard M, Kostenis E, Müller CE.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml400399f

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2009-07-01

In silico prediction of volume of distribution in human using linear and nonlinear models on a 669 compound data set.

Berellini G, Springer C, Waters NJ, Lombardo F.

J Med Chem · journal article · DOI 10.1021/jm9004658

Bibliografisk träff 2005-07-01

Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.

Jolivette LJ, Ward KW.

J Pharm Sci · comparative study; journal article · DOI 10.1002/jps.20373

Bibliografisk träff 2005-02-01

CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist.

Baron BM, Cregge RJ, Farr RA, Friedrich D, Gross RS, Harrison BL, Janowick DA, Matthews D, McCloskey TC, Meikrantz S, Nyce PL, Vaz R, Metz WA.

J Med Chem · journal article · DOI 10.1021/jm0491849

Bibliografisk träff 2003-11-01

Enantiomerically pure tetrahydroquinoline derivatives as in vivo potent antagonists of the glycine binding site associated to the NMDA receptor.

Di Fabio R, Tranquillini E, Bertani B, Alvaro G, Micheli F, Sabbatini F, Pizzi MD, Pentassuglia G, Pasquarello A, Messeri T, Donati D, Ratti E, Arban R, Dal Forno G, Reggiani A, Barnaby RJ.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2003.06.001

Bibliografisk träff 1998-07-01

Unusual synthesis of new glycine antagonists via sequential aldol condensation-lactonization-elimination reaction.

Giacobbe SA, Baraldi D, Di Fabio R.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(98)00284-4

Bibliografisk träff 1998-03-01

(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists.

Balsamini C, Bedini A, Diamantini G, Spadoni G, Tontini A, Tarzia G, Di Fabio R, Feriani A, Reggiani A, Tedesco G, Valigi R.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm970416w

Bibliografisk träff 1998-01-01

5-Aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists.

Auberson YP, Acklin P, Allgeier H, Biollaz M, Bischoff S, Ofner S, Veenstra SJ.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(97)10187-1

Bibliografisk träff 1997-12-01

Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists.

Rowley M, Kulagowski JJ, Watt AP, Rathbone D, Stevenson GI, Carling RW, Baker R, Marshall GR, Kemp JA, Foster AC, Grimwood S, Hargreaves R, Hurley C, Saywell KL, Tricklebank MD, Leeson PD.

J Med Chem · journal article · DOI 10.1021/jm970417o