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Publikationer i urvalet

16 träffar

Bibliografisk träff 2023-12-26

Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer.

Wang Y, Wang C, Liu T, Qi H, Chen S, Cai X, Zhang M, Aliper A, Ren F, Ding X, Zhavoronkov A.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.3c01476

Bibliografisk träff 2021-02-03

Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling.

Nikhar S, Siokas I, Schlicher L, Lee S, Gyrd-Hansen M, Degterev A, Cuny GD.

Eur J Med Chem · research-article; journal article · DOI 10.1016/j.ejmech.2021.113252

Bibliografisk träff 2020-11-02

Synthetic Lethality through the Lens of Medicinal Chemistry.

Myers SH, Ortega JA, Cavalli A.

J Med Chem · research support, non-u.s. gov't; review-article; review; journal article · DOI 10.1021/acs.jmedchem.0c00766

Bibliografisk träff 2020-07-10

Structure-activity relationships of Wee1 inhibitors: A review.

Du X, Li J, Luo X, Li R, Li F, Zhang Y, Shi J, He J.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2020.112524

Bibliografisk träff 2018-10-24

Computer-aided design, synthesis and biological characterization of novel inhibitors for PKMYT1.

Najjar A, Platzer C, Luft A, Aßmann CA, Elghazawy NH, Erdmann F, Sippl W, Schmidt M.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.10.050

Bibliografisk träff 2018-06-20

Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II.

Platzer C, Najjar A, Rohe A, Erdmann F, Sippl W, Schmidt M.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2018.06.027

Bibliografisk träff 2017-09-14

Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.

Zhu JY, Cuellar RA, Berndt N, Lee HE, Olesen SH, Martin MP, Jensen JT, Georg GI, Schönbrunn E.

J Med Chem · research-article; journal article · DOI 10.1021/acs.jmedchem.7b00996

Bibliografisk träff 2012-06-12

Evaluation of potential Myt1 kinase inhibitors by TR-FRET based binding assay.

Rohe A, Göllner C, Wichapong K, Erdmann F, Al-Mazaideh GM, Sippl W, Schmidt M.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2012.06.007

Bibliografisk träff 2011-11-23

In vitro and in silico studies on substrate recognition and acceptance of human PKMYT1, a Cdk1 inhibitory kinase.

Rohe A, Erdmann F, Bäßler C, Wichapong K, Sippl W, Schmidt M.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2011.11.064

Bibliografisk träff 2010-05-01

Thousands of chemical starting points for antimalarial lead identification.

Gamo FJ, Sanz LM, Vidal J, de Cozar C, Alvarez E, Lavandera JL, Vanderwall DE, Green DV, Kumar V, Hasan S, Brown JR, Peishoff CE, Cardon LR, Garcia-Bustos JF.

Nature · research support, non-u.s. gov't; journal article · DOI 10.1038/nature09107

Bibliografisk träff 2007-10-13

2D Autocorrelation, CoMFA, and CoMSIA modeling of protein tyrosine kinases' inhibition by substituted pyrido[2,3-d]pyrimidine derivatives.

Caballero J, Fernández M, Saavedra M, González-Nilo FD.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.10.024

Bibliografisk träff 2005-04-01

Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1.

Palmer BD, Smaill JB, Rewcastle GW, Dobrusin EM, Kraker A, Moore CW, Steinkampf RW, Denny WA.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2005.01.079

Bibliografisk träff 2000-08-01

Synthesis and structure-activity relationships of 7-substituted 3-(2, 6-dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as selective inhibitors of pp60(c-src).

Thompson AM, Rewcastle GW, Boushelle SL, Hartl BG, Kraker AJ, Lu GH, Batley BL, Panek RL, Showalter HD, Denny WA.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm000148t

Bibliografisk träff 1998-10-01

Synthesis and tyrosine kinase inhibitory activity of a series of 2-amino-8H-pyrido[2,3-d]pyrimidines: identification of potent, selective platelet-derived growth factor receptor tyrosine kinase inhibitors.

Boschelli DH, Wu Z, Klutchko SR, Showalter HD, Hamby JM, Lu GH, Major TC, Dahring TK, Batley B, Panek RL, Keiser J, Hartl BG, Kraker AJ, Klohs WD, Roberts BJ, Patmore S, Elliott WL, Steinkampf R, Bradford LA, Hallak H, Doherty AM.

J Med Chem · journal article · DOI 10.1021/jm980398y

Bibliografisk träff 1998-08-01

2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.

Klutchko SR, Hamby JM, Boschelli DH, Wu Z, Kraker AJ, Amar AM, Hartl BG, Shen C, Klohs WD, Steinkampf RW, Driscoll DL, Nelson JM, Elliott WL, Roberts BJ, Stoner CL, Vincent PW, Dykes DJ, Panek RL, Lu GH, Major TC, Dahring TK, Hallak H, Bradford LA, Showalter HD, Doherty AM.

J Med Chem · journal article · DOI 10.1021/jm9802259

Bibliografisk träff 1998-05-01

Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors.

Trumpp-Kallmeyer S, Rubin JR, Humblet C, Hamby JM, Showalter HD.

J Med Chem · journal article · DOI 10.1021/jm970634p