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Publikationer i urvalet

30 träffar

Bibliografisk träff 2024-09-03

Natural Product-Inspired Discovery of Naphthoquinone-Furo-Piperidine Derivatives as Novel STAT3 Inhibitors for the Treatment of Triple-Negative Breast Cancer.

Fan C, Lou S, Shen C, Liao J, Ni H, Chen S, Zhu Z, Hu X, Xie W, Zhao H, Cui S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.4c00872

Bibliografisk träff 2024-04-30

Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level.

Zhang L, Liu P, Jiang Y, Fan D, He X, Zhang J, Luo B, Sui J, Luo Y, Fu X, Yang T.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2024.116448

Bibliografisk träff 2023-05-18

Synthesis and structure-activity relationship studies of naphthoquinones as STAT3 inhibitors.

Yamashita M, Nakamori Y, Tsukamoto A, Furuno N, Iida A.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2023.117331

Bibliografisk träff 2022-10-25

Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer Treatment.

He P, Bian A, Miao Y, Jin W, Chen H, He J, Li L, Sun Y, Ye J, Liu M, Yi Z, Zhou W, Chen Y.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.2c01554

Bibliografisk träff 2022-09-14

Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr705/Ser727 Inhibitory Activity for Gastric Cancer Treatment.

He P, Miao Y, Sun Y, Bian A, Jin W, Chen H, Ye J, He J, Peng Y, Gu H, Liu M, Yi Z, Chen Y.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.2c00413

Bibliografisk träff 2021-08-26

Conjugates Derived from Lapatinib Derivatives with Cancer Cell Stemness Inhibitors Effectively Reversed Drug Resistance in Triple-Negative Breast Cancer.

Wang Y, Lv Z, Chen F, Wang X, Gou S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c01013

Bibliografisk träff 2021-04-09

Discovery of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition.

Wang Y, Lv Z, Chen F, Wang X, Gou S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c00131

Bibliografisk träff 2021-01-28

Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91.

Hanafi M, Chen X, Neamati N.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.0c01897

Bibliografisk träff 2021-01-03

A perspective on medicinal chemistry approaches towards adenomatous polyposis coli and Wnt signal based colorectal cancer inhibitors.

Phull MS, Jadav SS, Gundla R, Mainkar PS.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2020.113149

Bibliografisk träff 2020-12-22

Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors.

Brotherton-Pleiss C, Yue P, Zhu Y, Nakamura K, Chen W, Fu W, Kubota C, Chen J, Alonso-Valenteen F, Mikhael S, Medina-Kauwe L, Tius MA, Lopez-Tapia F, Turkson J.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.0c01705

Bibliografisk träff 2020-12-16

Cancer Stem Cell (CSC) Inhibitors in Oncology-A Promise for a Better Therapeutic Outcome: State of the Art and Future Perspectives.

Kharkar PS.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.0c01336

Bibliografisk träff 2020-10-25

Identification, Structure-Activity Relationships of Marine-Derived Indolocarbazoles, and a Dual PKCθ/δ Inhibitor with Potent Antipancreatic Cancer Efficacy.

Wang J, Jin W, Zhou X, Li J, Xu C, Ma Z, Wang J, Qin L, Zhou B, Ding W, Gao T, Yao H, Chen Z.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.0c01271

Bibliografisk träff 2020-10-22

Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study.

Wang F, Feng KR, Zhao JY, Zhang JW, Shi XW, Zhou J, Gao D, Lin GQ, Tian P.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2020.115822

Bibliografisk träff 2020-08-28

A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species.

Hu S, Sechi M, Singh PK, Dai L, McCann S, Sun D, Ljungman M, Neamati N.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.0c01016

Bibliografisk träff 2020-06-25

Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy.

Feng KR, Wang F, Shi XW, Tan YX, Zhao JY, Zhang JW, Li QH, Lin GQ, Gao D, Tian P.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112428

Bibliografisk träff 2020-05-26

Synthesis and biological evaluation of novel isothiazoloquinoline quinone analogues.

Chen L, Xie YZ, Luo ZY, Liu LJ, Zou ZZ, Liu HD, Kong FR, Hao Y, Gao JL, Wang LL, Ma DY, Liu SY.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2020.127286

Bibliografisk träff 2020-01-28

STAT3 inhibitory activity of naphthoquinones isolated from Tabebuia avellanedae.

Tahara T, Watanabe A, Yutani M, Yamano Y, Sagara M, Nagai S, Saito K, Yamashita M, Ihara M, Iida A.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2020.115347

Bibliografisk träff 2019-07-16

Discovery of napabucasin derivatives for the treatment of tuberculosis.

Li C, Tang Y, Sang Z, Yang Y, Gao Y, Yang T, Fang C, Zhang T, Luo Y.

Medchemcomm · research-article; journal article · DOI 10.1039/c9md00295b

Bibliografisk träff 2018-11-01

A novel series of napabucasin derivatives as orally active inhibitors of signal transducer and activator of transcription 3 (STAT3).

Li C, Chen C, An Q, Yang T, Sang Z, Yang Y, Ju Y, Tong A, Luo Y.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.10.067

Bibliografisk träff 2018-07-13

Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells.

Löcken H, Clamor C, Müller K.

J Nat Prod · journal article · DOI 10.1021/acs.jnatprod.8b00247

Bibliografisk träff 2018-03-24

Design, synthesis and activity of BBI608 derivatives targeting on stem cells.

Zhou Q, Peng C, Du F, Zhou L, Shi Y, Du Y, Liu D, Sun W, Zhang M, Chen G.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.03.054

Bibliografisk träff 2017-05-25

Novel NO-releasing plumbagin derivatives: Design, synthesis and evaluation of antiproliferative activity.

Bao N, Ou J, Xu M, Guan F, Shi W, Sun J, Chen L.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.05.046

Bibliografisk träff 2012-08-07

Synthesis and structure-activity relationships of lapacho analogues. 1. Suppression of human keratinocyte hyperproliferation by 2-substituted naphtho[2,3-b]furan-4,9-diones, activation by enzymatic one- and two-electron reduction, and intracellular generation of superoxide.

Reichstein A, Vortherms S, Bannwitz S, Tentrop J, Prinz H, Müller K.

J Med Chem · journal article · DOI 10.1021/jm3009597

Bibliografisk träff 2008-09-17

Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol.

Eyong KO, Kumar PS, Kuete V, Folefoc GN, Nkengfack EA, Baskaran S.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2008.09.053

Bibliografisk träff 2000-04-01

Cytotoxic constituents of the roots of Ekmanianthe longiflora.

Peraza-Sánchez SR, Chávez D, Chai HB, Shin YG, García R, Mejía M, Fairchild CR, Lane KE, Menendez AT, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD.

J Nat Prod · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/np990528l

Bibliografisk träff 1999-08-01

Potential antipsoriatic agents: lapacho compounds as potent inhibitors of HaCaT cell growth.

Müller K, Sellmer A, Wiegrebe W.

J Nat Prod · journal article · DOI 10.1021/np990139r

Bibliografisk träff 1998-10-01

Synthesis and cytotoxicity of acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9-diones.

Huang LJ, Kuo SC, Perng CY, Chao YH, Wu TS, McPhail AT, Mauger A, Cheng HH, Lee KH.

Bioorg Med Chem Lett · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(98)00496-x

Bibliografisk träff 1989-09-01

Studies on inhibitors of skin tumor promotion, VI. Inhibitory effects of quinones on Epstein-Barr virus activation.

Konoshima T, Kozuka M, Koyama J, Okatani T, Tagahara K, Tokuda H.

J Nat Prod · journal article · DOI 10.1021/np50065a012

Bibliografisk träff 1987-11-01

Antitumor agents. 89. Psychorubrin, a new cytotoxic naphthoquinone from Psychotria rubra and its structure-activity relationships.

Hayashi T, Smith FT, Lee KH.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00394a013

Bibliografisk träff 1982-09-01

Plant anticancer agents. XII. Isolation and structure elucidation of new cytotoxic quinones from Tabebuia cassinoides.

Rao MM, Kingston DG.

J Nat Prod · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/np50023a014

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Publikationer i urvalet

Natural Product-Inspired Discovery of Naphthoquinone-Furo-Piperidine Derivatives as Novel STAT3 Inhibitors for the Treatment of Triple-Negative Breast Cancer.

Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level.

Synthesis and structure-activity relationship studies of naphthoquinones as STAT3 inhibitors.

Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer Treatment.

Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr<sup>705</sup>/Ser<sup>727</sup> Inhibitory Activity for Gastric Cancer Treatment.

Conjugates Derived from Lapatinib Derivatives with Cancer Cell Stemness Inhibitors Effectively Reversed Drug Resistance in Triple-Negative Breast Cancer.

Discovery of 5-(3-Chlorophenylamino)benzo[<i>c</i>][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition.

Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91.

A perspective on medicinal chemistry approaches towards adenomatous polyposis coli and Wnt signal based colorectal cancer inhibitors.

Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors.

Cancer Stem Cell (CSC) Inhibitors in Oncology-A Promise for a Better Therapeutic Outcome: State of the Art and Future Perspectives.

Identification, Structure-Activity Relationships of Marine-Derived Indolocarbazoles, and a Dual PKCθ/δ Inhibitor with Potent Antipancreatic Cancer Efficacy.

Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study.

A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species.

Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy.

Synthesis and biological evaluation of novel isothiazoloquinoline quinone analogues.

STAT3 inhibitory activity of naphthoquinones isolated from Tabebuia avellanedae.

Discovery of napabucasin derivatives for the treatment of tuberculosis.

A novel series of napabucasin derivatives as orally active inhibitors of signal transducer and activator of transcription 3 (STAT3).

Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells.

Design, synthesis and activity of BBI608 derivatives targeting on stem cells.

Novel NO-releasing plumbagin derivatives: Design, synthesis and evaluation of antiproliferative activity.

Synthesis and structure-activity relationships of lapacho analogues. 1. Suppression of human keratinocyte hyperproliferation by 2-substituted naphtho[2,3-b]furan-4,9-diones, activation by enzymatic one- and two-electron reduction, and intracellular generation of superoxide.

Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol.

Cytotoxic constituents of the roots of Ekmanianthe longiflora.

Potential antipsoriatic agents: lapacho compounds as potent inhibitors of HaCaT cell growth.

Synthesis and cytotoxicity of acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9-diones.

Studies on inhibitors of skin tumor promotion, VI. Inhibitory effects of quinones on Epstein-Barr virus activation.

Antitumor agents. 89. Psychorubrin, a new cytotoxic naphthoquinone from Psychotria rubra and its structure-activity relationships.

Plant anticancer agents. XII. Isolation and structure elucidation of new cytotoxic quinones from Tabebuia cassinoides.