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Publikationer i urvalet

14 träffar

Bibliografisk träff 2022-08-08

Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.

Fu H, Rong J, Chen Z, Zhou J, Collier T, Liang SH.

J Med Chem · research support, non-u.s. gov't; review; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/acs.jmedchem.2c00633

Bibliografisk träff 2021-04-22

Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects.

Gallo M, Moreno E, Defaus S, Ortega-Alvaro A, Gonzalez A, Robledo P, Cavaco M, Neves V, Castanho MARB, Casadó V, Pardo L, Maldonado R, Andreu D.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.1c00484

Bibliografisk träff 2018-03-16

Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT<sub>2A</sub> receptor (5-HT<sub>2A</sub>R) antagonist M100907.

Gilbertson SR, Chen YC, Soto CA, Yang Y, Rice KC, Cunningham KA, Anastasio NC.

Bioorg Med Chem Lett · research support, n.i.h., intramural; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2018.02.058

Bibliografisk träff 2010-11-01

Novel spirotetracyclic zwitterionic dual H(1)/5-HT(2A) receptor antagonists for the treatment of sleep disorders.

Gianotti M, Botta M, Brough S, Carletti R, Castiglioni E, Corti C, Dal-Cin M, Delle Fratte S, Korajac D, Lovric M, Merlo G, Mesic M, Pavone F, Piccoli L, Rast S, Roscic M, Sava A, Smehil M, Stasi L, Togninelli A, Wigglesworth MJ.

J Med Chem · journal article · DOI 10.1021/jm100856p

Bibliografisk träff 2010-04-24

Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders.

Ladduwahetty T, Gilligan M, Humphries A, Merchant KJ, Fish R, McAlister G, Ivarsson M, Dominguez M, O'Connor D, MacLeod AM.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2010.04.090

Bibliografisk träff 2009-07-01

Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.

Zachariae U, Giordanetto F, Leach AG.

J Med Chem · journal article · DOI 10.1021/jm900002x

Bibliografisk träff 2009-03-14

Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.

Herth MM, Kramer V, Piel M, Palner M, Riss PJ, Knudsen GM, Rösch F.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2009.03.021

Bibliografisk träff 2008-01-30

2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists.

Shireman BT, Dvorak CA, Rudolph DA, Bonaventure P, Nepomuceno D, Dvorak L, Miller KL, Lovenberg TW, Carruthers NI.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.01.090

Bibliografisk träff 2007-12-25

Total synthesis and evaluation of [18F]MHMZ.

Herth MM, Debus F, Piel M, Palner M, Knudsen GM, Lüddens H, Rösch F.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2007.12.054

Bibliografisk träff 2005-08-01

4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia.

Fish LR, Gilligan MT, Humphries AC, Ivarsson M, Ladduwahetty T, Merchant KJ, O'Connor D, Patel S, Philipps E, Vargas HM, Hutson PH, MacLeod AM.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2005.05.104

Bibliografisk träff 2002-05-01

Synthesis, receptor potency, and selectivity of halogenated diphenylpiperidines as serotonin 5-HT2A ligands for PET or SPECT brain imaging.

Fu X, Tan PZ, Kula NS, Baldessarini R, Tamagnan G, Innis RB, Baldwin RM.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm0200411

Bibliografisk träff 2002-01-01

4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.

Fletcher SR, Burkamp F, Blurton P, Cheng SK, Clarkson R, O'Connor D, Spinks D, Tudge M, van Niel MB, Patel S, Chapman K, Marwood R, Shepheard S, Bentley G, Cook GP, Bristow LJ, Castro JL, Hutson PH, MacLeod AM.

J Med Chem · journal article · DOI 10.1021/jm011030v

Bibliografisk träff 2001-02-01

Current and novel approaches to the drug treatment of schizophrenia.

Rowley M, Bristow LJ, Hutson PH.

J Med Chem · review; journal article · DOI 10.1021/jm0002432

Bibliografisk träff 2000-12-01

Solid-phase synthesis of 2,3-disubstituted indoles: discovery of a novel, high-affinity, selective h5-HT2A antagonist.

Smith AL, Stevenson GI, Lewis S, Patel S, Castro JL.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(00)00558-8