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Publikationer i urvalet

13 träffar

Bibliografisk träff 2017-01-09

Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach.

Nara H, Kaieda A, Sato K, Naito T, Mototani H, Oki H, Yamamoto Y, Kuno H, Santou T, Kanzaki N, Terauchi J, Uchikawa O, Kori M.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.6b01007

Bibliografisk träff 2016-09-14

Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors.

Nara H, Sato K, Kaieda A, Oki H, Kuno H, Santou T, Kanzaki N, Terauchi J, Uchikawa O, Kori M.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2016.09.009

Bibliografisk träff 2014-10-15

Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach.

Nara H, Sato K, Naito T, Mototani H, Oki H, Yamamoto Y, Kuno H, Santou T, Kanzaki N, Terauchi J, Uchikawa O, Kori M.

J Med Chem · journal article · DOI 10.1021/jm500981k

Bibliografisk träff 2014-08-07

Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site.

Nara H, Sato K, Naito T, Mototani H, Oki H, Yamamoto Y, Kuno H, Santou T, Kanzaki N, Terauchi J, Uchikawa O, Kori M.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2014.07.025

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2010-09-01

Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.

Becker DP, Barta TE, Bedell LJ, Boehm TL, Bond BR, Carroll J, Carron CP, Decrescenzo GA, Easton AM, Freskos JN, Funckes-Shippy CL, Heron M, Hockerman S, Howard CP, Kiefer JR, Li MH, Mathis KJ, McDonald JJ, Mehta PP, Munie GE, Sunyer T, Swearingen CA, Villamil CI, Welsch D, Williams JM, Yu Y, Yao J.

J Med Chem · journal article · DOI 10.1021/jm100669j

Bibliografisk träff 2009-11-01

Hydroxamates: relationships between structure and plasma stability.

Flipo M, Charton J, Hocine A, Dassonneville S, Deprez B, Deprez-Poulain R.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm900648x

Bibliografisk träff 2009-06-01

Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13.

Monovich LG, Tommasi RA, Fujimoto RA, Blancuzzi V, Clark K, Cornell WD, Doti R, Doughty J, Fang J, Farley D, Fitt J, Ganu V, Goldberg R, Goldstein R, Lavoie S, Kulathila R, Macchia W, Parker DT, Melton R, O'Byrne E, Pastor G, Pellas T, Quadros E, Reel N, Roland DM, Sakane Y, Singh H, Skiles J, Somers J, Toscano K, Wigg A, Zhou S, Zhu L, Shieh WC, Xue S, McQuire LW.

J Med Chem · journal article · DOI 10.1021/jm801394m

Bibliografisk träff 2005-02-01

Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).

Kim SH, Pudzianowski AT, Leavitt KJ, Barbosa J, McDonnell PA, Metzler WJ, Rankin BM, Liu R, Vaccaro W, Pitts W.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2004.12.016

Bibliografisk träff 2003-06-01

Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.

Aranapakam V, Davis JM, Grosu GT, Baker J, Ellingboe J, Zask A, Levin JI, Sandanayaka VP, Du M, Skotnicki JS, DiJoseph JF, Sung A, Sharr MA, Killar LM, Walter T, Jin G, Cowling R, Tillett J, Zhao W, McDevitt J, Xu ZB.

J Med Chem · journal article · DOI 10.1021/jm0205550

Bibliografisk träff 2001-09-01

Selective, orally active MMP inhibitors with an aryl backbone.

Barta TE, Becker DP, Bedell LJ, De Crescenzo GA, McDonald JJ, Mehta P, Munie GE, Villamil CI.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(01)00487-5

Bibliografisk träff 2000-12-01

Synthesis and activity of selective MMP inhibitors with an aryl backbone.

Barta TE, Becker DP, Bedell LJ, De Crescenzo GA, McDonald JJ, Munie GE, Rao S, Shieh HS, Stegeman R, Stevens AM, Villamil CI.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(00)00584-9

Bibliografisk träff 2000-02-01

Protease inhibitors: current status and future prospects.

Leung D, Abbenante G, Fairlie DP.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/jm990412m