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Publikationer i urvalet

10 träffar

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2023-10-31

Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors.

Wu A, Shi K, Wang J, Zhang R, Wang Y.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2023.115923

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2020-08-20

Factor XII/XIIa inhibitors: Their discovery, development, and potential indications.

Davoine C, Bouckaert C, Fillet M, Pochet L.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2020.112753

Bibliografisk träff 2020-02-20

Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers <i>in Vitro</i> and <i>in Vivo</i>.

Ju Y, He L, Zhou Y, Yang T, Sun K, Song R, Yang Y, Li C, Sang Z, Bao R, Luo Y.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.9b01746

Bibliografisk träff 2019-11-13

Fibrinolysis Inhibitors: Potential Drugs for the Treatment and Prevention of Bleeding.

Steinmetzer T, Pilgram O, Wenzel BM, Wiedemeyer SJA.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.9b01060

Bibliografisk träff 2018-05-14

Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform.

Pant SM, Mukonoweshuro A, Desai B, Ramjee MK, Selway CN, Tarver GJ, Wright AG, Birchall K, Chapman TM, Tervonen TA, Klefström J.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.7b01698

Bibliografisk träff 2015-12-01

Discovery and SAR of Novel and Selective Inhibitors of Urokinase Plasminogen Activator (uPA) with an Imidazo[1,2-a]pyridine Scaffold.

Gladysz R, Adriaenssens Y, De Winter H, Joossens J, Lambeir AM, Augustyns K, Van der Veken P.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.5b01171

Bibliografisk träff 2013-01-22

Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.

Wittwer MB, Zur AA, Khuri N, Kido Y, Kosaka A, Zhang X, Morrissey KM, Sali A, Huang Y, Giacomini KM.

J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm301302s

Bibliografisk träff 2001-10-01

Combinatorial synthesis of SSAO inhibitors using sonogashira coupling: SAR of aryl propargylic amines.

Conn C, Shimmon R, Cordaro F, Hargraves TL, Ibrahim P.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(01)00506-6