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Publikationer i urvalet

22 träffar

Bibliografisk träff 2024-08-13

Identification of an m6A Natural Inhibitor, Lobeline, That Reverses Lenvatinib Resistance in Hepatocellular Tumors.

Zhao L, Ma H, Jiang Y, Li Y, Qiao L, Chen Y, Jiang X, Wang L, Wang S, Fan X.

J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jnatprod.4c00406

Bibliografisk träff 2023-04-12

Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents.

Khadilkar A, Bunch ZL, Wagoner J, Ravindran V, Oda JM, Vidar WS, Clark TN, Manwill PK, Todd DA, Barr SA, Olinger LK, Fink SL, Strangman WK, Linington RG, MacMillan JB, Cech NB, Polyak SJ.

J Nat Prod · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jnatprod.3c00159

Bibliografisk träff 2023-01-18

Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach.

Wasilewicz A, Kirchweger B, Bojkova D, Abi Saad MJ, Langeder J, Bütikofer M, Adelsberger S, Grienke U, Cinatl J, Petermann O, Scapozza L, Orts J, Kirchmair J, Rabenau HF, Rollinger JM.

J Nat Prod · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jnatprod.2c00843

Bibliografisk träff 2018-10-04

Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter.

Provencher BA, Eshleman AJ, Johnson RA, Shi X, Kryatova O, Nelson J, Tian J, Gonzalez M, Meltzer PC, Janowsky A.

J Med Chem · research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.8b00542

Bibliografisk träff 2017-10-20

Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2.

Hankosky ER, Joolakanti SR, Nickell JR, Janganati V, Dwoskin LP, Crooks PA.

Bioorg Med Chem Lett · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2017.10.039

Bibliografisk träff 2015-07-17

Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane.

Bach TB, Jensen AA, Petersen JG, Sørensen TE, Della Volpe S, Liu J, Blaazer AR, van Muijlwijk-Koezen JE, Balle T, Frølund B.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2015.07.024

Bibliografisk träff 2015-06-20

The twin drug approach for novel nicotinic acetylcholine receptor ligands.

Tomassoli I, Gündisch D.

Bioorg Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2015.06.034

Bibliografisk träff 2013-03-11

Pharmacological chaperones as therapeutics for lysosomal storage diseases.

Boyd RE, Lee G, Rybczynski P, Benjamin ER, Khanna R, Wustman BA, Valenzano KJ.

J Med Chem · review; journal article · DOI 10.1021/jm301557k

Bibliografisk träff 2013-03-01

Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse.

Zheng G, Horton DB, Penthala NR, Nickell JR, Culver JP, Deaciuc AG, Dwoskin LP, Crooks PA.

Medchemcomm · research-article; journal article · DOI 10.1039/c3md20374c

Bibliografisk träff 2012-08-06

Shape-based reprofiling of FDA-approved drugs for the H₁ histamine receptor.

Vasudevan SR, Moore JB, Schymura Y, Churchill GC.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm300671m

Bibliografisk träff 2011-12-09

Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.

Edink E, Akdemir A, Jansen C, van Elk R, Zuiderveld O, de Kanter FJ, van Muijlwijk-Koezen JE, Smit AB, Leurs R, de Esch IJ.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2011.12.008

Bibliografisk träff 2009-12-06

Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters.

Hojahmat M, Horton DB, Norrholm SD, Miller DK, Grinevich VP, Deaciuc AG, Dwoskin LP, Crooks PA.

Bioorg Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2009.12.002

Bibliografisk träff 2009-12-01

Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).

Vartak AP, Nickell JR, Chagkutip J, Dwoskin LP, Crooks PA.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm900770h

Bibliografisk träff 2008-10-14

Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2.

Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA.

Bioorg Med Chem Lett · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2008.10.042

Bibliografisk träff 2008-01-01

Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.

Kruhlak NL, Choi SS, Contrera JF, Weaver JL, Willard JM, Hastings KL, Sancilio LF.

Toxicol Mech Methods · journal article · DOI 10.1080/15376510701857262

Bibliografisk träff 2006-08-14

Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters.

Zheng G, Horton DB, Deaciuc AG, Dwoskin LP, Crooks PA.

Bioorg Med Chem Lett · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2006.07.070

Bibliografisk träff 2005-10-01

Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands.

Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA.

Bioorg Med Chem Lett · research support, u.s. gov't, p.h.s.; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2005.07.032

Bibliografisk träff 2005-08-01

Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter.

Zheng G, Dwoskin LP, Deaciuc AG, Norrholm SD, Crooks PA.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm0501228

Bibliografisk träff 2003-11-01

Rigidified acetylcholine mimics: conformational requirements for binding to neuronal nicotinic receptors.

Villeneuve G, Cécyre D, Lejeune H, Drouin M, Lan R, Quirion R.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(03)00728-5

Bibliografisk träff 1999-09-01

Lobeline: structure-affinity investigation of nicotinic acetylcholinergic receptor binding.

Flammia D, Dukat M, Damaj MI, Martin B, Glennon RA.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm990286m

Bibliografisk träff 1993-04-01

Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies.

Strobl GR, von Kruedener S, Stöckigt J, Guengerich FP, Wolff T.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00061a004

Bibliografisk träff 1985-09-01

Structure-activity relationships of some pyridine, piperidine, and pyrrolidine analogues for enhancing and inhibiting the binding of (+/-)-[3H]nicotine to the rat brain P2 preparation.

Sloan JW, Martin WR, Hook R, Hernandez J.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00147a021

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Publikationer i urvalet

Identification of an m6A Natural Inhibitor, Lobeline, That Reverses Lenvatinib Resistance in Hepatocellular Tumors.

Modulation of <i>in Vitro</i> SARS-CoV-2 Infection by <i>Stephania tetrandra</i> and Its Alkaloid Constituents.

Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach.

Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter.

Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [<sup>3</sup>H]dopamine uptake at the vesicular monoamine transporter-2.

Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane.

The twin drug approach for novel nicotinic acetylcholine receptor ligands.

Pharmacological chaperones as therapeutics for lysosomal storage diseases.

Exploring the effect of <i>N</i>-substitution in <i>nor</i>-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse.

Shape-based reprofiling of FDA-approved drugs for the H₁ histamine receptor.

Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.

Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters.

Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).

Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2.

Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.

Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters.

Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands.

Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter.

Rigidified acetylcholine mimics: conformational requirements for binding to neuronal nicotinic receptors.

Lobeline: structure-affinity investigation of nicotinic acetylcholinergic receptor binding.

Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies.

Structure-activity relationships of some pyridine, piperidine, and pyrrolidine analogues for enhancing and inhibiting the binding of (+/-)-[3H]nicotine to the rat brain P2 preparation.