Fluorine in anti-HIV drugs approved by FDA from 1981 to 2023.
Han S, Lu Y.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2023.115586 PUBLIKATIONSREGISTRET
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12 träffarSynthesis and Antiviral Evaluation of Carbocyclic Nucleoside Analogs of Nucleoside Reverse Transcriptase Translocation Inhibitor MK-8591 (4'-Ethynyl-2-fluoro-2'-deoxyadenosine).
Alexandre FR, Rahali R, Rahali H, Guillon S, Convard T, Fillgrove K, Lai MT, Meillon JC, Xu M, Small J, Dousson CB, Raheem IT.
J Med Chem · journal article · DOI 10.1021/acs.jmedchem.8b00141Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides.
Zhang HW, Detorio M, Herman BD, Solomon S, Bassit L, Nettles JH, Obikhod A, Tao SJ, Mellors JW, Sluis-Cremer N, Coats SJ, Schinazi RF.
Eur J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ejmech.2011.05.051Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Sluis-Cremer N, Koontz D, Bassit L, Hernandez-Santiago BI, Detorio M, Rapp KL, Amblard F, Bondada L, Grier J, Coats SJ, Schinazi RF, Mellors JW.
Antimicrob Agents Chemother · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.00392-09Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
Prado-Prado FJ, Martinez de la Vega O, Uriarte E, Ubeira FM, Chou KC, González-Díaz H.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2008.11.075Mechanisms by which the G333D mutation in human immunodeficiency virus type 1 Reverse transcriptase facilitates dual resistance to zidovudine and lamivudine.
Zelina S, Sheen CW, Radzio J, Mellors JW, Sluis-Cremer N.
Antimicrob Agents Chemother · research-article; journal article · DOI 10.1128/aac.00904-07Novel drug resistance pattern associated with the mutations K70G and M184V in human immunodeficiency virus type 1 reverse transcriptase.
Bradshaw D, Malik S, Booth C, Van Houtte M, Pattery T, Waters A, Ainsworth J, Geretti AM.
Antimicrob Agents Chemother · research-article; journal article · DOI 10.1128/aac.00687-07Synthesis and evaluation of 2'-substituted cyclobutyl nucleosides and nucleotides as potential anti-HIV agents.
Li Y, Mao S, Hager MW, Becnel KD, Schinazi RF, Liotta DC.
Bioorg Med Chem Lett · comparative study; research-article; research support, u.s. gov't, non-p.h.s.; evaluation study; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2007.03.094Antiviral and cellular metabolism interactions between Dexelvucitabine and lamivudine.
Hernandez-Santiago BI, Mathew JS, Rapp KL, Grier JP, Schinazi RF.
Antimicrob Agents Chemother · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.01543-06Strong and selective inhibitors of hepatitis B virus replication among novel N4-hydroxy- and 5-methyl-beta-L-deoxycytidine analogues.
Matthes E, Funk A, Krahn I, Gaertner K, von Janta-Lipinski M, Lin L, Will H, Sirma H.
Antimicrob Agents Chemother · comparative study; research support, non-u.s. gov't; research-article; evaluation study; journal article · DOI 10.1128/aac.00001-07Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase.
Boyle NA, Rajwanshi VK, Prhavc M, Wang G, Fagan P, Chen F, Ewing GJ, Brooks JL, Hurd T, Leeds JM, Bruice TW, Cook PD.
J Med Chem · journal article · DOI 10.1021/jm040101yEffects of fluorine substitution of cytosine analogues on the binding affinity to HIV-1 reverse transcriptase.
Chong Y, Choo H, Chu CK.
Bioorg Med Chem Lett · comparative study; research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/j.bmcl.2003.10.042