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Publikationer i urvalet

20 träffar

Bibliografisk träff 2024-06-13

Rutaecarpine-inspired scaffold-hopping strategy and Ullmann cross-coupling based synthetic approach: Identification of pyridopyrimidinone-indole based novel anticancer chemotypes.

Yadav M, Roy N, Mandal K, Nagpure M, Santra MK, Guchhait SK.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2024.117799

Bibliografisk träff 2021-03-10

Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells.

Dominici C, Sgarioto N, Yu Z, Sesma-Sanz L, Masson JY, Richard S, Raynal NJ.

Clin Epigenetics · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/s13148-021-01037-1

Bibliografisk träff 2021-02-08

Medulloblastoma drugs in development: Current leads, trials and drawbacks.

Wen J, Hadden MK.

Eur J Med Chem · research-article; review; journal article · DOI 10.1016/j.ejmech.2021.113268

Bibliografisk träff 2018-02-24

Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms.

Dadashpour S, Emami S.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2018.02.065

Bibliografisk träff 2017-04-05

Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.

Chadha N, Silakari O.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2017.04.003

Bibliografisk träff 2017-01-09

Quantitative measurement of intracellular HDAC1/2 drug occupancy using a <i>trans</i>-cyclooctene largazole thiol probe.

Xu H, Roberts LR, Chou S, Pierce B, Narayanan A, Jones LH.

Medchemcomm · research-article; journal article · DOI 10.1039/c6md00633g

Bibliografisk träff 2016-02-03

Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.

Cincinelli R, Zwick V, Musso L, Zuco V, De Cesare M, Zunino F, Simoes-Pires C, Nurisso A, Giannini G, Cuendet M, Dallavalle S.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.02.001

Bibliografisk träff 2015-01-02

Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).

Carrillo AK, Guiguemde WA, Guy RK.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2014.12.066

Bibliografisk träff 2011-08-01

The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.

Shultz M, Fan J, Chen C, Cho YS, Davis N, Bickford S, Buteau K, Cao X, Holmqvist M, Hsu M, Jiang L, Liu G, Lu Q, Patel C, Suresh JR, Selvaraj M, Urban L, Wang P, Yan-Neale Y, Whitehead L, Zhang H, Zhou L, Atadja P.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2011.06.015

Bibliografisk träff 2011-06-17

Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.

Shultz MD, Cao X, Chen CH, Cho YS, Davis NR, Eckman J, Fan J, Fekete A, Firestone B, Flynn J, Green J, Growney JD, Holmqvist M, Hsu M, Jansson D, Jiang L, Kwon P, Liu G, Lombardo F, Lu Q, Majumdar D, Meta C, Perez L, Pu M, Ramsey T, Remiszewski S, Skolnik S, Traebert M, Urban L, Uttamsingh V, Wang P, Whitebread S, Whitehead L, Yan-Neale Y, Yao YM, Zhou L, Atadja P.

J Med Chem · journal article · DOI 10.1021/jm200388e

Bibliografisk träff 2011-04-29

Structure-based optimization of click-based histone deacetylase inhibitors.

Hou J, Feng C, Li Z, Fang Q, Wang H, Gu G, Shi Y, Liu P, Xu F, Yin Z, Shen J, Wang P.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2011.04.027

Bibliografisk träff 2010-11-12

Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity.

Auzzas L, Larsson A, Matera R, Baraldi A, Deschênes-Simard B, Giannini G, Cabri W, Battistuzzi G, Gallo G, Ciacci A, Vesci L, Pisano C, Hanessian S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm101092u

Bibliografisk träff 2010-04-01

Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).

Cho YS, Whitehead L, Li J, Chen CH, Jiang L, Vögtle M, Francotte E, Richert P, Wagner T, Traebert M, Lu Q, Cao X, Dumotier B, Fejzo J, Rajan S, Wang P, Yan-Neale Y, Shao W, Atadja P, Shultz M.

J Med Chem · journal article · DOI 10.1021/jm100007m

Bibliografisk träff 2010-02-07

Chemical phylogenetics of histone deacetylases.

Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R.

Nat Chem Biol · research-article; journal article · DOI 10.1038/nchembio.313

Bibliografisk träff 2009-08-07

Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.

Tessier P, Smil DV, Wahhab A, Leit S, Rahil J, Li Z, Déziel R, Besterman JM.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.08.010

Bibliografisk träff 2008-02-14

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.

Jones P, Altamura S, De Francesco R, Gallinari P, Lahm A, Neddermann P, Rowley M, Serafini S, Steinkühler C.

Bioorg Med Chem Lett · comparative study; journal article · DOI 10.1016/j.bmcl.2008.02.025

Bibliografisk träff 2007-10-23

Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.

Lahm A, Paolini C, Pallaoro M, Nardi MC, Jones P, Neddermann P, Sambucini S, Bottomley MJ, Lo Surdo P, Carfí A, Koch U, De Francesco R, Steinkühler C, Gallinari P.

Proc Natl Acad Sci U S A · research support, non-u.s. gov't; research-article; journal article · DOI 10.1073/pnas.0706487104

Bibliografisk träff 2007-10-17

Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity.

Moradei OM, Mallais TC, Frechette S, Paquin I, Tessier PE, Leit SM, Fournel M, Bonfils C, Trachy-Bourget MC, Liu J, Yan TP, Lu AH, Rahil J, Wang J, Lefebvre S, Li Z, Vaisburg AF, Besterman JM.

J Med Chem · journal article · DOI 10.1021/jm701079h

Bibliografisk träff 2003-11-01

Histone deacetylase inhibitors.

Miller TA, Witter DJ, Belvedere S.

J Med Chem · review; journal article · DOI 10.1021/jm0303094

Bibliografisk träff 2003-10-01

N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).

Remiszewski SW, Sambucetti LC, Bair KW, Bontempo J, Cesarz D, Chandramouli N, Chen R, Cheung M, Cornell-Kennon S, Dean K, Diamantidis G, France D, Green MA, Howell KL, Kashi R, Kwon P, Lassota P, Martin MS, Mou Y, Perez LB, Sharma S, Smith T, Sorensen E, Taplin F, Trogani N, Versace R, Walker H, Weltchek-Engler S, Wood A, Wu A, Atadja P.

J Med Chem · journal article · DOI 10.1021/jm030235w