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Publikationer i urvalet

11 träffar

Bibliografisk träff 2018-04-17

Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors.

Capuzzi SJ, Sun W, Muratov EN, Martínez-Romero C, He S, Zhu W, Li H, Tawa G, Fisher EG, Xu M, Shinn P, Qiu X, García-Sastre A, Zheng W, Tropsha A.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.8b00035

Bibliografisk träff 2015-03-18

Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).

Hoveyda HR, Fraser GL, Roy MO, Dutheuil G, Batt F, El Bousmaqui M, Korac J, Lenoir F, Lapin A, Noël S, Blanc S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm5017413

Bibliografisk träff 2013-12-15

Design and synthesis of potential dual NK(1)/NK(3) receptor antagonists.

Hanessian S, Babonneau V, Boyer N, Mannoury la Cour C, Millan MJ, De Nanteuil G.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2013.12.033

Bibliografisk träff 2012-05-22

Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK₁/NK₃ antagonists.

Bissantz C, Bohnert C, Hoffmann T, Marcuz A, Schnider P, Malherbe P.

J Med Chem · journal article · DOI 10.1021/jm2017072

Bibliografisk träff 2011-02-13

Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor.

Hoveyda HR, Roy MO, Blanc S, Noël S, Salvino JM, Ator MA, Fraser G.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2011.02.033

Bibliografisk träff 2010-11-03

Virtual screening to identify novel antagonists for the G protein-coupled NK3 receptor.

Geldenhuys WJ, Kuzenko SR, Simmons MA.

J Med Chem · journal article · DOI 10.1021/jm1010012

Bibliografisk träff 2010-09-17

Rational design of novel pyrrolidine derivatives as orally active neurokinin-3 receptor antagonists.

Ratni H, Ballard TM, Bissantz C, Hoffmann T, Jablonski P, Knoflach F, Knust H, Malherbe P, Nettekoven M, Patiny-Adam A, Riemer C, Schmitt M, Spooren W.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2010.08.138

Bibliografisk träff 2009-11-01

Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures.

Malherbe P, Kratzeisen C, Marcuz A, Zenner MT, Nettekoven MH, Ratni H, Wettstein JG, Bissantz C.

J Med Chem · journal article · DOI 10.1021/jm900948q

Bibliografisk träff 2008-12-07

New quinoline NK3 receptor antagonists with CNS activity.

Smith PW, Wyman PA, Lovell P, Goodacre C, Serafinowska HT, Vong A, Harrington F, Flynn S, Bradley DM, Porter R, Coggon S, Murkitt G, Searle K, Thomas DR, Watson JM, Martin W, Wu Z, Dawson LA.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.12.005

Bibliografisk träff 1999-03-01

Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412).

Giardina GA, Raveglia LF, Grugni M, Sarau HM, Farina C, Medhurst AD, Graziani D, Schmidt DB, Rigolio R, Luttmann M, Cavagnera S, Foley JJ, Vecchietti V, Hay DW.

J Med Chem · journal article · DOI 10.1021/jm980633c

Bibliografisk träff 1996-06-01

2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor.

Giardina GA, Sarau HM, Farina C, Medhurst AD, Grugni M, Foley JJ, Raveglia LF, Schmidt DB, Rigolio R, Vassallo M, Vecchietti V, Hay DW.

J Med Chem · comparative study; journal article · DOI 10.1021/jm9602423