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Publikationer i urvalet

9 träffar

Bibliografisk träff 2015-08-26

Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.

Borišek J, Vizovišek M, Sosnowski P, Turk B, Turk D, Mohar B, Novič M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.5b00746

Bibliografisk träff 2014-08-11

3-Cyano-3-aza-β-amino Acid Derivatives as Inhibitors of Human Cysteine Cathepsins.

Schmitz J, Beckmann AM, Dudic A, Li T, Sellier R, Bartz U, Gütschow M.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml500238q

Bibliografisk träff 2012-10-11

Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.

Crawford JJ, Kenny PW, Bowyer J, Cook CR, Finlayson JE, Heyes C, Highton AJ, Hudson JA, Jestel A, Krapp S, Martin S, Macfaul PA, McDermott BP, McGuire TM, Morley AD, Morris JJ, Page KM, Ribeiro LR, Sawney H, Steinbacher S, Smith C, Dossetter AG.

J Med Chem · journal article · DOI 10.1021/jm301119s

Bibliografisk träff 2012-07-10

(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.

Dossetter AG, Beeley H, Bowyer J, Cook CR, Crawford JJ, Finlayson JE, Heron NM, Heyes C, Highton AJ, Hudson JA, Jestel A, Kenny PW, Krapp S, Martin S, MacFaul PA, McGuire TM, Gutierrez PM, Morley AD, Morris JJ, Page KM, Ribeiro LR, Sawney H, Steinbacher S, Smith C, Vickers M.

J Med Chem · journal article · DOI 10.1021/jm3007257

Bibliografisk träff 2010-06-01

Emerging targets in osteoporosis disease modification.

Allen JG, Fotsch C, Babij P.

J Med Chem · review; journal article · DOI 10.1021/jm9018756

Bibliografisk träff 2009-01-01

A simple in vitro assay for assessing the reactivity of nitrile containing compounds.

MacFaul PA, Morley AD, Crawford JJ.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.12.105

Bibliografisk träff 2008-01-15

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

Gauthier JY, Chauret N, Cromlish W, Desmarais S, Duong LT, Falgueyret JP, Kimmel DB, Lamontagne S, Léger S, LeRiche T, Li CS, Massé F, McKay DJ, Nicoll-Griffith DA, Oballa RM, Palmer JT, Percival MD, Riendeau D, Robichaud J, Rodan GA, Rodan SB, Seto C, Thérien M, Truong VL, Venuti MC, Wesolowski G, Young RN, Zamboni R, Black WC.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2007.12.047

Bibliografisk träff 2005-12-01

Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.

Palmer JT, Bryant C, Wang DX, Davis DE, Setti EL, Rydzewski RM, Venkatraman S, Tian ZQ, Burrill LC, Mendonca RV, Springman E, McCarter J, Chung T, Cheung H, Janc JW, McGrath M, Somoza JR, Enriquez P, Yu ZW, Strickley RM, Liu L, Venuti MC, Percival MD, Falgueyret JP, Prasit P, Oballa R, Riendeau D, Young RN, Wesolowski G, Rodan SB, Johnson C, Kimmel DB, Rodan G.

J Med Chem · journal article · DOI 10.1021/jm058198r

Bibliografisk träff 2005-12-01

Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.

Falgueyret JP, Desmarais S, Oballa R, Black WC, Cromlish W, Khougaz K, Lamontagne S, Massé F, Riendeau D, Toulmond S, Percival MD.

J Med Chem · journal article · DOI 10.1021/jm0504961