Progress in the development of TRPV1 small-molecule antagonists: Novel Strategies for pain management.
Zhu K, Wang L, Liao T, Li W, Zhou J, You Y, Shi J.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2023.115806 PUBLIKATIONSREGISTRET
Gå till forskningen.
Publikationsdata från Europe PMC och PubMed. Följ källhänvisningar från ämnesregistret till originalpublikationerna.
Publikationer som ChEBI hänvisar till för sb-705498. Visa hela publikationsregistret
En publikationsträff är inte en slutsats. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.
Publikationer i urvalet
7 träffarResearch progress and challenges of TRPV1 channel modulators as a prospective therapy for diabetic neuropathic pain.
Liu C, Miao R, Raza F, Qian H, Tian X.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2022.114893Optimization of 4-arylthiophene-3-carboxylic acid derivatives as inhibitors of ANO1: Lead optimization studies toward their analgesic efficacy for inflammatory pain.
Wang Y, Hu X, Huang H, Jin Z, Gao J, Guo Y, Zhong Y, Li Z, Zong X, Wang K, Zhang L, Liu Z.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114413Discovery of (S)-N-(3-isopropylphenyl)-2-(5-phenylthiazol-2-yl)pyrrolidine-1-carboxamide as potent and brain-penetrant TRPV1 antagonist.
Qiao Y, Zhang Y, Qiao Z, He W, Chen Y, Song D, Wang G, Guo N, Shao L, Tian Z, Wang Q, Yan L, Qian H.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114191Design, synthesis, and biological evaluation of novel biphenyl-4-carboxamide derivatives as orally available TRPV1 antagonists.
Oka H, Yonezawa K, Kamikawa A, Ikegai K, Asai N, Shirakami S, Miyamoto S, Watanabe T, Kiso T, Takemoto Y, Tamura S, Kuramochi T.
Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2018.06.001Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
Blum CA, Caldwell T, Zheng X, Bakthavatchalam R, Capitosti S, Brielmann H, De Lombaert S, Kershaw MT, Matson D, Krause JE, Cortright D, Crandall M, Martin WJ, Murphy BA, Boyce S, Jones AB, Mason G, Rycroft W, Perrett H, Conley R, Burnaby-Davies N, Chenard BL, Hodgetts KJ.
J Med Chem · journal article · DOI 10.1021/jm100051gDiscovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.
Rami HK, Thompson M, Stemp G, Fell S, Jerman JC, Stevens AJ, Smart D, Sargent B, Sanderson D, Randall AD, Gunthorpe MJ, Davis JB.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2006.03.030