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Publikationer i urvalet

28 träffar

Bibliografisk träff 2024-01-18

Acetogenins from the Stem of <i>Uvaria rufa</i> and Their Cytotoxic Activity.

Gurgul A, Khin M, Souliya O, Sydara K, Burdette JE, Johnson JJ, Che CT.

J Nat Prod · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jnatprod.3c00838

Bibliografisk träff 2013-08-15

Enantioselective effects of (+)- and (-)-citronellal on animal and plant microtubules.

Altshuler O, Abu-Abied M, Chaimovitsh D, Shechter A, Frucht H, Dudai N, Sadot E.

J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/np4002702

Bibliografisk träff 2013-05-03

Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity.

Zheng J, Deng L, Chen M, Xiao X, Xiao S, Guo C, Xiao G, Bai L, Ye W, Zhang D, Chen H.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2013.04.057

Bibliografisk träff 2012-09-26

Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Brunhofer G, Fallarero A, Karlsson D, Batista-Gonzalez A, Shinde P, Gopi Mohan C, Vuorela P.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2012.09.040

Bibliografisk träff 2012-03-07

Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff.

Sivasothy Y, Hadi AH, Mohamad K, Leong KH, Ibrahim H, Sulaiman SF, Ooi KL, Awang K.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2012.02.064

Bibliografisk träff 2011-12-15

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.

PLoS Comput Biol · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1371/journal.pcbi.1002310

Bibliografisk träff 2011-08-26

Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway.

Krishnegowda G, Prakasha Gowda AS, Tagaram HR, Carroll KF, Irby RB, Sharma AK, Amin S.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2011.08.044

Bibliografisk träff 2011-06-12

Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.

Prinz H, Schmidt P, Böhm KJ, Baasner S, Müller K, Gerlach M, Günther EG, Unger E.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2011.06.010

Bibliografisk träff 2011-05-26

N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Prinz H, Chamasmani B, Vogel K, Böhm KJ, Aicher B, Gerlach M, Günther EG, Amon P, Ivanov I, Müller K.

J Med Chem · journal article · DOI 10.1021/jm200436t

Bibliografisk träff 2010-09-15

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Ekins S, Williams AJ, Xu JJ.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.110.035113

Bibliografisk träff 2010-08-01

Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.

Nickel HC, Schmidt P, Böhm KJ, Baasner S, Müller K, Gerlach M, Unger E, Günther EG, Prinz H.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2010.04.032

Bibliografisk träff 2010-08-01

Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives.

Surkau G, Böhm KJ, Müller K, Prinz H.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2010.04.019

Bibliografisk träff 2010-07-01

Developing structure-activity relationships for the prediction of hepatotoxicity.

Greene N, Fisk L, Naven RT, Note RR, Patel ML, Pelletier DJ.

Chem Res Toxicol · journal article · DOI 10.1021/tx1000865

Bibliografisk träff 2009-09-06

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ.

Nat Chem Biol · research support, n.i.h., intramural; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/nchembio.215

Bibliografisk träff 2009-05-08

Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).

Tundis R, Bonesi M, Deguin B, Loizzo MR, Menichini F, Conforti F, Tillequin F, Menichini F.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2009.05.006

Bibliografisk träff 2009-03-01

10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Prinz H, Schmidt P, Böhm KJ, Baasner S, Müller K, Unger E, Gerlach M, Günther EG.

J Med Chem · journal article · DOI 10.1021/jm801338r

Bibliografisk träff 2008-06-20

Selective alkylation of beta(II)-tubulin and thioredoxin-1 by structurally related subsets of aryl chloroethylureas leading to either anti-microtubules or redox modulating agents.

Fortin JS, Côté MF, Lacroix J, Desjardins M, Petitclerc E, C-Gaudreault R.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2008.06.028

Bibliografisk träff 2007-10-31

Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Zuse A, Schmidt P, Baasner S, Böhm KJ, Müller K, Gerlach M, Günther EG, Unger E, Prinz H.

J Med Chem · comparative study; journal article · DOI 10.1021/jm0708984

Bibliografisk träff 2007-04-08

Chemical genetics reveals a complex functional ground state of neural stem cells.

Diamandis P, Wildenhain J, Clarke ID, Sacher AG, Graham J, Bellows DS, Ling EK, Ward RJ, Jamieson LG, Tyers M, Dirks PB.

Nat Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1038/nchembio873

Bibliografisk träff 2007-02-07

Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity.

Williams NS, Burgett AW, Atkins AS, Wang X, Harran PG, McKnight SL.

Proc Natl Acad Sci U S A · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1073/pnas.0611340104

Bibliografisk träff 2006-12-01

9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Zuse A, Schmidt P, Baasner S, Böhm KJ, Müller K, Gerlach M, Günther EG, Unger E, Prinz H.

J Med Chem · journal article · DOI 10.1021/jm0605031

Bibliografisk träff 2006-06-05

Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay.

Morrell A, Jayaraman M, Nagarajan M, Fox BM, Meckley MR, Ioanoviciu A, Pommier Y, Antony S, Hollingshead M, Cushman M.

Bioorg Med Chem Lett · journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2006.05.048

Bibliografisk träff 2003-07-01

Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Prinz H, Ishii Y, Hirano T, Stoiber T, Camacho Gomez JA, Schmidt P, Düssmann H, Burger AM, Prehn JH, Günther EG, Unger E, Umezawa K.

J Med Chem · journal article · DOI 10.1021/jm0307685

Bibliografisk träff 2003-07-01

Cytotoxic diterpenes from Scoparia dulcis.

Ahsan M, Islam SK, Gray AI, Stimson WH.

J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/np020356j

Bibliografisk träff 2002-10-01

Design and synthesis of a pro-drug of vinblastine targeted at treatment of prostate cancer with enhanced efficacy and reduced systemic toxicity.

Brady SF, Pawluczyk JM, Lumma PK, Feng DM, Wai JM, Jones R, DeFeo-Jones D, Wong BK, Miller-Stein C, Lin JH, Oliff A, Freidinger RM, Garsky VM.

J Med Chem · journal article · DOI 10.1021/jm020139f

Bibliografisk träff 1997-06-01

Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia.

Wu TS, Liou MJ, Kuoh CS, Teng CM, Nagao T, Lee KH.

J Nat Prod · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/np970163+

Bibliografisk träff 1979-04-01

Structure-activity relationships of dimeric Catharanthus alkaloids. 2. Experimental antitumor activities of N-substituted deacetylvinblastine amide (vindesine) sulfates.

Conrad RA, Cullinan GJ, Gerzon K, Poore GA.

J Med Chem · journal article · DOI 10.1021/jm00190a008

Bibliografisk träff 1978-01-01

Structure-activity relationships of dimeric Catharanthus alkaloids. 1. Deacetylvinblastine amide (vindesine) sulfate.

Barnett CJ, Cullinan GJ, Gerzon K, Hoying RC, Jones WE, Newlon WM, Poore GA, Robison RL, Sweeney MJ, Todd GC, Dyke RW, Nelson RL.

J Med Chem · journal article · DOI 10.1021/jm00199a016