ActiQs / Forskning

PUBLIKATIONSREGISTRET

Gå till forskningen.

Publikationsdata från Europe PMC och PubMed. Följ källhänvisningar från ämnesregistret till originalpublikationerna.

Publikationer som ChEBI hänvisar till för navarixin anhydrous. Visa hela publikationsregistret

En publikationsträff är inte en slutsats. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.

Publikationer i urvalet

17 träffar

Bibliografisk träff 2023-07-31

Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2.

Casella BM, Farmer JP, Nesheva DN, Williams HEL, Charlton SJ, Holliday ND, Laughton CA, Mistry SN.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.3c00849

Bibliografisk träff 2023-03-05

Optimization of triazolo[4,5-d]pyrimidines towards human CC chemokine receptor 7 (CCR7) antagonists.

Van Hoof M, Claes S, Proj M, Van Loy T, Schols D, Gobec S, Dehaen W, De Jonghe S.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.115240

Bibliografisk träff 2021-09-09

Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists.

Zhang X, Luo J, Li Q, Xin Q, Ye L, Zhu Q, Shi Z, Zhan F, Chu B, Liu Z, Jiang Y.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113812

Bibliografisk träff 2021-05-13

Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis.

Ronchetti R, Moroni G, Carotti A, Gioiello A, Camaioni E.

RSC Med Chem · review-article; review; journal article · DOI 10.1039/d1md00058f

Bibliografisk träff 2021-04-08

Discovery of 1,5-Dihydro-4<i>H</i>-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2.

Che J, Wang Z, Shen Z, Zhuang W, Ying H, Hu Y, Hu Y, Xie X, Dong X.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.1c00113

Bibliografisk träff 2020-07-23

Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity.

Li Z, Wang X, Lin Y, Wang Y, Wu S, Xia K, Xu C, Ma H, Zheng J, Luo L, Zhu F, He S, Zhang X.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112537

Bibliografisk träff 2019-11-26

Structural optimization of aminopyrimidine-based CXCR4 antagonists.

Zhu F, Wang Y, Du Q, Ge W, Li Z, Wang X, Fu C, Luo L, Tian S, Ma H, Zheng J, Zhang Y, Sun X, He S, Zhang X.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.111914

Bibliografisk träff 2019-11-06

Targeting CXCR1/2: The medicinal potential as cancer immunotherapy agents, antagonists research highlights and challenges ahead.

Che J, Song R, Chen B, Dong X.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2019.111853

Bibliografisk träff 2018-02-28

Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists.

Lu H, Yang T, Xu Z, Lin X, Ding Q, Zhang Y, Cai X, Dong K, Gong S, Zhang W, Patel M, Copley RCB, Xiang J, Guan X, Wren P, Ren F.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.7b01854

Bibliografisk träff 2014-10-12

2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: discovery of novel and potent CXCR2 antagonists.

Lu H, Yang T, Xu Z, Wren PB, Zhang Y, Cai X, Patel M, Dong K, Zhang Q, Zhang W, Guan X, Xiang J, Elliott JD, Lin X, Ren F.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2014.10.003

Bibliografisk träff 2012-09-24

Chemokine receptor antagonists.

Pease J, Horuk R.

J Med Chem · journal article · DOI 10.1021/jm300682j

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2009-05-18

Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region.

Aki C, Chao J, Ferreira JA, Dwyer MP, Yu Y, Chao J, Merritt RJ, Lai G, Wu M, Hipkin RW, Fan X, Gonsiorek W, Fosseta J, Rindgen D, Fine J, Lundell D, Taveras AG, Biju P.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.05.049

Bibliografisk träff 2009-01-15

Fluoroalkyl alpha side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2-CXCR1 dual antagonists.

Biju P, Taveras AG, Dwyer MP, Yu Y, Chao J, Hipkin RW, Fan X, Rindgen D, Fine J, Lundell D.

Bioorg Med Chem Lett · comparative study; journal article · DOI 10.1016/j.bmcl.2009.01.033

Bibliografisk träff 2008-02-10

Synthesis and structure-activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists.

Lai G, Merritt JR, He Z, Feng D, Chao J, Czarniecki MF, Rokosz LL, Stauffer TM, Rindgen D, Taveras AG.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.02.010

Bibliografisk träff 2007-04-10

C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists.

Chao J, Taveras AG, Chao J, Aki C, Dwyer M, Yu Y, Purakkattle B, Rindgen D, Jakway J, Hipkin W, Fosetta J, Fan X, Lundell D, Fine J, Minnicozzi M, Phillips J, Merritt JR.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2007.04.016

Bibliografisk träff 2006-12-01

Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist.

Dwyer MP, Yu Y, Chao J, Aki C, Chao J, Biju P, Girijavallabhan V, Rindgen D, Bond R, Mayer-Ezel R, Jakway J, Hipkin RW, Fossetta J, Gonsiorek W, Bian H, Fan X, Terminelli C, Fine J, Lundell D, Merritt JR, Rokosz LL, Kaiser B, Li G, Wang W, Stauffer T, Ozgur L, Baldwin J, Taveras AG.

J Med Chem · journal article · DOI 10.1021/jm0609622