Influence of Trp-Cage on the Function and Stability of GLP-1R Agonist Exenatide Derivatives.
Horváth D, Stráner P, Taricska N, Fazekas Z, Menyhárd DK, Perczel A.
J Med Chem · research-article; journal article · DOI 10.1021/acs.jmedchem.4c01553 PUBLIKATIONSREGISTRET
Gå till forskningen.
Publikationsdata från Europe PMC och PubMed. Följ källhänvisningar från ämnesregistret till originalpublikationerna.
Publikationer som ChEBI hänvisar till för exenatide. Visa hela publikationsregistret
En publikationsträff är inte en slutsats. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.
Publikationer i urvalet
24 träffarAn insight into the pharmacology of cysteine/methionine containing peptide drugs.
Sharma A, Singh LR.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2024.116456Modifying a Hydroxyl Patch in Glucagon-like Peptide 1 Produces Biased Agonists with Unique Signaling Profiles.
Wang P, Hill TA, Mitchell J, Fitzsimmons RL, Xu W, Loh Z, Suen JY, Lim J, Iyer A, Fairlie DP.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.2c00653A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
Griffith DA, Edmonds DJ, Fortin JP, Kalgutkar AS, Kuzmiski JB, Loria PM, Saxena AR, Bagley SW, Buckeridge C, Curto JM, Derksen DR, Dias JM, Griffor MC, Han S, Jackson VM, Landis MS, Lettiere D, Limberakis C, Liu Y, Mathiowetz AM, Patel JC, Piotrowski DW, Price DA, Ruggeri RB, Tess DA.
J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.1c01856Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis.
Milliken BT, Elfers C, Chepurny OG, Chichura KS, Sweet IR, Borner T, Hayes MR, De Jonghe BC, Holz GG, Roth CL, Doyle RP.
J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.0c01783Is GPR146 really the receptor for proinsulin C-peptide?
Lindfors L, Sundström L, Fröderberg Roth L, Meuller J, Andersson S, Kihlberg J.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2020.127208Novel lipid side chain modified exenatide analogs emerged prolonged glucoregulatory activity and potential body weight management properties.
Li C, Cai X, Dai Y, Liu C, Bi X, Zhou J, Li Q, Sun L, Huang W, Hou Z, Qian H.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2019.115070Novel nonapeptide GLP (28-36) amide derivatives with improved hypoglycemic and body weight lowering effects.
Li L, Wu L, E X, Yan W, Cai X, Han J, Sun L.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2019.03.014Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations.
Evers A, Bossart M, Pfeiffer-Marek S, Elvert R, Schreuder H, Kurz M, Stengelin S, Lorenz M, Herling A, Konkar A, Lukasczyk U, Pfenninger A, Lorenz K, Haack T, Kadereit D, Wagner M.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.8b00292Novel fatty acid chain modified GLP-1 derivatives with prolonged in vivo glucose-lowering ability and balanced glucoregulatory activity.
Cai X, Sun L, Dai Y, Avraham Y, Liu C, Han J, Liu Y, Feng D, Huang W, Qian H.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2018.04.022Synthesis and in vitro biological evaluation of new pyrimidines as glucagon-like peptide-1 receptor agonists.
AlNeyadi SS, Adem A, Amer N, Salem AA, Abdou IM.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2017.09.032Highly potent antiobesity effect of a short-length peptide YY analog in mice.
Nishizawa N, Niida A, Adachi Y, Kanematsu-Yamaki Y, Masuda Y, Kumano S, Yokoyama K, Noguchi Y, Asakawa T, Hirabayashi H, Amano N, Takekawa S, Ohtaki T, Asami T.
Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2017.08.044Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists.
Evers A, Haack T, Lorenz M, Bossart M, Elvert R, Henkel B, Stengelin S, Kurz M, Glien M, Dudda A, Lorenz K, Kadereit D, Wagner M.
J Med Chem · journal article · DOI 10.1021/acs.jmedchem.7b00174DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.
Drug Discov Today · review; journal article · DOI 10.1016/j.drudis.2016.02.015Design, synthesis, and biological activity of novel dicoumarol glucagon-like peptide 1 conjugates.
Han J, Sun L, Chu Y, Li Z, Huang D, Zhu X, Qian H, Huang W.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm4017448Design, synthesis and biological evaluation of novel peptide MC62 analogues as potential antihyperglycemic agents.
Yang B, Mei Y, Wang X, Deng X, Qian H, Huang W.
Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2013.11.043Recent progress and future options in the development of GLP-1 receptor agonists for the treatment of diabesity.
Lorenz M, Evers A, Wagner M.
Bioorg Med Chem Lett · review; journal article · DOI 10.1016/j.bmcl.2013.05.022Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles.
Wang Y, Liu JJ, Dransfield PJ, Zhu L, Wang Z, Du X, Jiao X, Su Y, Li AR, Brown SP, Kasparian A, Vimolratana M, Yu M, Pattaropong V, Houze JB, Swaminath G, Tran T, Nguyen K, Guo Q, Zhang J, Zhuang R, Li F, Miao L, Bartberger MD, Correll TL, Chow D, Wong S, Luo J, Lin DC, Medina JC.
ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml300427uIdentification of glycosylated exendin-4 analogue with prolonged blood glucose-lowering activity through glycosylation scanning substitution.
Ueda T, Ito T, Tomita K, Togame H, Fumoto M, Asakura K, Oshima T, Nishimura S, Hanasaki K.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2010.06.002Eleven amino acid glucagon-like peptide-1 receptor agonists with antidiabetic activity.
Mapelli C, Natarajan SI, Meyer JP, Bastos MM, Bernatowicz MS, Lee VG, Pluscec J, Riexinger DJ, Sieber-McMaster ES, Constantine KL, Smith-Monroy CA, Golla R, Ma Z, Longhi DA, Shi D, Xin L, Taylor JR, Koplowitz B, Chi CL, Khanna A, Robinson GW, Seethala R, Antal-Zimanyi IA, Stoffel RH, Han S, Whaley JM, Huang CS, Krupinski J, Ewing WR.
J Med Chem · journal article · DOI 10.1021/jm900752aPreparation and structural, biochemical, and pharmaceutical characterizations of bile acid-modified long-acting exendin-4 derivatives.
Son S, Chae SY, Kim CW, Choi YG, Jung SY, Lee S, Lee KC.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm901153xDevelopment of the renal glucose reabsorption inhibitors: a new mechanism for the pharmacotherapy of diabetes mellitus type 2.
Washburn WN.
J Med Chem · review; journal article · DOI 10.1021/jm8013019Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity.
Miranda LP, Winters KA, Gegg CV, Patel A, Aral J, Long J, Zhang J, Diamond S, Guido M, Stanislaus S, Ma M, Li H, Rose MJ, Poppe L, Véniant MM.
J Med Chem · journal article · DOI 10.1021/jm701522bDesign, synthesis, and biological evaluation of substituted-N-(thieno[2,3-b]pyridin-3-yl)-guanidines, N-(1H-pyrrolo[2,3-b]pyridin-3-yl)-guanidines, and N-(1H-indol-3-yl)-guanidines.
Bahekar RH, Jain MR, Goel A, Patel DN, Prajapati VM, Gupta AA, Jadav PA, Patel PR.
Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2007.02.029