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Publikationer i urvalet

34 träffar

Bibliografisk träff 2024-03-19

Design and Synthesis of Cyclolipopeptide Mimics of Dysoxylactam A and Evaluation of the Reversing Potencies against P-Glycoprotein-Mediated Multidrug Resistance.

Yang GZ, Wang L, Gao K, Zhu X, Lou LG, Yue JM.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.3c01920

Bibliografisk träff 2023-08-09

Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers.

Braconi L, Dei S, Contino M, Riganti C, Bartolucci G, Manetti D, Romanelli MN, Perrone MG, Colabufo NA, Guglielmo S, Teodori E.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.115716

Bibliografisk träff 2022-07-31

Updated chemical scaffolds of ABCG2 inhibitors and their structure-inhibition relationships for future development.

Moinul M, Amin SA, Jha T, Gayen S.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2022.114628

Bibliografisk träff 2021-10-04

Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2).

Wong ILK, Zhu X, Chan KF, Liu Z, Chan CF, Chow TS, Chong TC, Law MC, Cui J, Chow LMC, Chan TH.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c00779

Bibliografisk träff 2021-03-17

Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.

Smolinski MP, Urgaonkar S, Pitzonka L, Cutler M, Lee G, Suh KH, Lau JYN.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.0c01826

Bibliografisk träff 2019-01-09

Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells.

Riganti C, Contino M, Guglielmo S, Perrone MG, Salaroglio IC, Milosevic V, Giampietro R, Leonetti F, Rolando B, Lazzarato L, Colabufo NA, Fruttero R.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.8b01655

Bibliografisk träff 2017-12-02

Monoterpene indole alkaloid azine derivatives as MDR reversal agents.

Paterna A, Khonkarn R, Mulhovo S, Moreno A, Madeira Girio P, Baubichon-Cortay H, Falson P, Ferreira MU.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2017.11.052

Bibliografisk träff 2016-08-23

Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus.

McGowan D, Herschke F, Pauwels F, Stoops B, Last S, Pieters S, Scholliers A, Thoné T, Van Schoubroeck B, De Pooter D, Mostmans W, Khamlichi MD, Embrechts W, Dhuyvetter D, Smyej I, Arnoult E, Demin S, Borghys H, Fanning G, Vlach J, Raboisson P.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.6b00747

Bibliografisk träff 2016-05-20

Structure-activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transport.

Miyata K, Nakagawa Y, Kimura Y, Ueda K, Akamatsu M.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2016.05.039

Bibliografisk träff 2013-06-14

Modular construction of quaternary hemiaminal-based inhibitor candidates and their in cellulo assessment with HIV-1 protease.

Gros G, Martinez L, Gimenez AS, Adler P, Maurin P, Wolkowicz R, Falson P, Hasserodt J.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2013.06.018

Bibliografisk träff 2013-03-04

Benzanilide-Biphenyl Replacement: A Bioisosteric Approach to Quinoline Carboxamide-Type ABCG2 Modulators.

Ochoa-Puentes C, Bauer S, Kühnle M, Bernhardt G, Buschauer A, König B.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml4000832

Bibliografisk träff 2012-05-18

Brain distribution and bioavailability of elacridar after different routes of administration in the mouse.

Sane R, Agarwal S, Elmquist WF.

Drug Metab Dispos · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1124/dmd.112.045930

Bibliografisk träff 2012-05-15

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Karlgren M, Vildhede A, Norinder U, Wisniewski JR, Kimoto E, Lai Y, Haglund U, Artursson P.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm300212s

Bibliografisk träff 2012-04-02

Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity.

Valdameri G, Gauthier C, Terreux R, Kachadourian R, Day BJ, Winnischofer SM, Rocha ME, Frachet V, Ronot X, Di Pietro A, Boumendjel A.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm2016528

Bibliografisk träff 2012-03-27

Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.

Jabeen I, Pleban K, Rinner U, Chiba P, Ecker GF.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm201705f

Bibliografisk träff 2012-01-19

Cerebrospinal fluid can be used as a surrogate to assess brain exposures of breast cancer resistance protein and P-glycoprotein substrates.

Xiao G, Black C, Hetu G, Sands E, Wang J, Caputo R, Rohde E, Gan LS.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.111.043703

Bibliografisk träff 2011-06-28

Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.

Lévesque JF, Bleasby K, Chefson A, Chen A, Dubé D, Ducharme Y, Fournier PA, Gagné S, Gallant M, Grimm E, Hafey M, Han Y, Houle R, Lacombe P, Laliberté S, MacDonald D, Mackay B, Papp R, Tschirret-Guth R.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2011.06.095

Bibliografisk träff 2011-04-28

Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2).

Puentes CO, Höcherl P, Kühnle M, Bauer S, Bürger K, Bernhardt G, Buschauer A, König B.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2011.04.094

Bibliografisk träff 2011-02-26

Radiosynthesis and in vivo evaluation of 1-[18F]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein.

Dörner B, Kuntner C, Bankstahl JP, Wanek T, Bankstahl M, Stanek J, Müllauer J, Bauer F, Mairinger S, Löscher W, Miller DW, Chiba P, Müller M, Erker T, Langer O.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.bmc.2011.02.039

Bibliografisk träff 2010-06-22

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor.

Bauer F, Kuntner C, Bankstahl JP, Wanek T, Bankstahl M, Stanek J, Mairinger S, Dörner B, Löscher W, Müller M, Erker T, Langer O.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.bmc.2010.06.057

Bibliografisk träff 2009-11-10

Novel lead for potent inhibitors of breast cancer resistance protein (BCRP).

Pick A, Müller H, Wiese M.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2009.11.004

Bibliografisk träff 2009-10-01

Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier.

Dörner B, Kuntner C, Bankstahl JP, Bankstahl M, Stanek J, Wanek T, Stundner G, Mairinger S, Löscher W, Müller M, Langer O, Erker T.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm900940f

Bibliografisk träff 2009-02-01

Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.

Kühnle M, Egger M, Müller C, Mahringer A, Bernhardt G, Fricker G, König B, Buschauer A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm8013822

Bibliografisk träff 2008-12-01

2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties.

Colabufo NA, Berardi F, Perrone R, Rapposelli S, Digiacomo M, Vanni M, Balsamo A.

J Med Chem · journal article · DOI 10.1021/jm800928j

Bibliografisk träff 2008-05-06

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

Pedersen JM, Matsson P, Bergström CA, Norinder U, Hoogstraate J, Artursson P.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm7015683

Bibliografisk träff 2008-02-08

Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents.

Colabufo NA, Berardi F, Perrone R, Rapposelli S, Digiacomo M, Vanni M, Balsamo A.

J Med Chem · journal article · DOI 10.1021/jm701267q

Bibliografisk träff 2008-02-02

4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators.

Colabufo NA, Berardi F, Cantore M, Perrone MG, Contino M, Inglese C, Niso M, Perrone R, Azzariti A, Simone GM, Paradiso A.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2008.01.055

Bibliografisk träff 2007-09-25

Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.

Colabufo NA, Berardi F, Cantore M, Perrone MG, Contino M, Inglese C, Niso M, Perrone R, Azzariti A, Simone GM, Porcelli L, Paradiso A.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2007.09.039

Bibliografisk träff 2007-06-04

Modulation of the cellular accumulation and intracellular activity of daptomycin towards phagocytized Staphylococcus aureus by the P-glycoprotein (MDR1) efflux transporter in human THP-1 macrophages and madin-darby canine kidney cells.

Lemaire S, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00090-07

Bibliografisk träff 2007-02-13

Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2.

Boumendjel A, Macalou S, Ahmed-Belkacem A, Blanc M, Di Pietro A.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.02.017