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Publikationer i urvalet

13 träffar

Bibliografisk träff 2023-08-23

Cannabinoformins: Designing Biguanide-Embedded, Orally Available, Peripherally Selective Cannabinoid-1 Receptor Antagonists for Metabolic Syndrome Disorders.

Dvorácskó S, Herrerias A, Oliverio A, Bhattacharjee P, Pommerolle L, Liu Z, Feng D, Lee YS, Hassan SA, Godlewski G, Cinar R, Iyer MR.

J Med Chem · research support, n.i.h., intramural; journal article · DOI 10.1021/acs.jmedchem.3c00599

Bibliografisk träff 2013-07-04

Peripherally restricted CB1 receptor blockers.

Chorvat RJ.

Bioorg Med Chem Lett · review; journal article · DOI 10.1016/j.bmcl.2013.06.066

Bibliografisk träff 2011-09-13

Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.

Yang Y, Miller KJ, Zhu Y, Hong Y, Tian Y, Murugesan N, Gu Z, O'Tanyi E, Keim WJ, Rohrbach KW, Johnghar S, Behnia K, Pelleymounter MA, Carlson KE, Ewing WR.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2011.09.016

Bibliografisk träff 2010-01-20

Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB(1) receptor antagonists.

Lange JH, van der Neut MA, den Hartog AP, Wals HC, Hoogendoorn J, van Stuivenberg HH, van Vliet BJ, Kruse CG.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2010.01.049

Bibliografisk träff 2009-06-02

Discovery and functional evaluation of diverse novel human CB(1) receptor ligands.

Foloppe N, Benwell K, Brooks TD, Kennett G, Knight AR, Misra A, Monck NJ.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.05.114

Bibliografisk träff 2009-04-01

Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists.

Pettersson H, Bülow A, Ek F, Jensen J, Ottesen LK, Fejzic A, Ma JN, Del Tredici AL, Currier EA, Gardell LR, Tabatabaei A, Craig D, McFarland K, Ott TR, Piu F, Burstein ES, Olsson R.

J Med Chem · journal article · DOI 10.1021/jm801534c

Bibliografisk träff 2008-03-26

Identification of novel cannabinoid CB1 receptor antagonists by using virtual screening with a pharmacophore model.

Wang H, Duffy RA, Boykow GC, Chackalamannil S, Madison VS.

J Med Chem · journal article · DOI 10.1021/jm701519h

Bibliografisk träff 2008-03-13

Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity.

Alig L, Alsenz J, Andjelkovic M, Bendels S, Bénardeau A, Bleicher K, Bourson A, David-Pierson P, Guba W, Hildbrand S, Kube D, Lübbers T, Mayweg AV, Narquizian R, Neidhart W, Nettekoven M, Plancher JM, Rocha C, Rogers-Evans M, Röver S, Schneider G, Taylor S, Waldmeier P.

J Med Chem · journal article · DOI 10.1021/jm701487t

Bibliografisk träff 2007-12-23

Bioisosteric replacement of dihydropyrazole of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N'-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole.

Srivastava BK, Soni R, Joharapurkar A, Sairam KV, Patel JZ, Goswami A, Shedage SA, Kar SS, Salunke RP, Gugale SB, Dhawas A, Kadam P, Mishra B, Sadhwani N, Unadkat VB, Mitra P, Jain MR, Patel PR.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2007.12.036

Bibliografisk träff 2007-12-07

Discovery of a novel class of selective human CB1 inverse agonists.

Foloppe N, Allen NH, Bentley CH, Brooks TD, Kennett G, Knight AR, Leonardi S, Misra A, Monck NJ, Sellwood DM.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2007.11.133

Bibliografisk träff 2006-12-01

Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity.

Lin LS, Lanza TJ, Jewell JP, Liu P, Shah SK, Qi H, Tong X, Wang J, Xu SS, Fong TM, Shen CP, Lao J, Xiao JC, Shearman LP, Stribling DS, Rosko K, Strack A, Marsh DJ, Feng Y, Kumar S, Samuel K, Yin W, Van der Ploeg LH, Goulet MT, Hagmann WK.

J Med Chem · journal article · DOI 10.1021/jm060996+

Bibliografisk träff 2005-11-01

Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity.

Lange JH, van Stuivenberg HH, Veerman W, Wals HC, Stork B, Coolen HK, McCreary AC, Adolfs TJ, Kruse CG.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2005.07.054

Bibliografisk träff 2004-01-01

Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists.

Lange JH, Coolen HK, van Stuivenberg HH, Dijksman JA, Herremans AH, Ronken E, Keizer HG, Tipker K, McCreary AC, Veerman W, Wals HC, Stork B, Verveer PC, den Hartog AP, de Jong NM, Adolfs TJ, Hoogendoorn J, Kruse CG.

J Med Chem · journal article · DOI 10.1021/jm031019q