Perspectives and challenges in developing small molecules targeting purine nucleoside phosphorylase.
Chen Y, Li Y, Gao J, Yu Q, Zhang Y, Zhang J.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2024.116437 PUBLIKATIONSREGISTRET
Gå till forskningen.
Publikationsdata från Europe PMC och PubMed. Följ källhänvisningar från ämnesregistret till originalpublikationerna.
Publikationer som ChEBI hänvisar till för ulodesine. Visa hela publikationsregistret
En publikationsträff är inte en slutsats. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.
Publikationer i urvalet
9 träffarPlasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues.
Cheviet T, Lefebvre-Tournier I, Wein S, Peyrottes S.
J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.9b00182Pharmacological urate-lowering approaches in chronic kidney disease.
Li X, Liu J, Ma L, Fu P.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2019.01.043The transition to magic bullets - transition state analogue drug design.
Evans GB, Schramm VL, Tyler PC.
Medchemcomm · review-article; review; journal article · DOI 10.1039/c8md00372fThird-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase.
Clinch K, Evans GB, Fröhlich RF, Furneaux RH, Kelly PM, Legentil L, Murkin AS, Li L, Schramm VL, Tyler PC, Woolhouse AD.
J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm801421qA beta-fluoroamine inhibitor of purine nucleoside phosphorylase.
Mason JM, Murkin AS, Li L, Schramm VL, Gainsford GJ, Skelton BW.
J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm800792bImmucillins in custom catalytic-site cavities.
Murkin AS, Clinch K, Mason JM, Tyler PC, Schramm VL.
Bioorg Med Chem Lett · research-article; journal article · DOI 10.1016/j.bmcl.2008.08.047Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases.
Evans GB, Furneaux RH, Greatrex B, Murkin AS, Schramm VL, Tyler PC.
J Med Chem · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1021/jm701265nSynthesis of second-generation transition state analogues of human purine nucleoside phosphorylase.
Evans GB, Furneaux RH, Lewandowicz A, Lewandowicz A, Schramm VL, Tyler PC.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm030305z