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Publikationer i urvalet

9 träffar

Bibliografisk träff 2021-12-20

Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis.

Wang X, Zhao R, Ji W, Zhou J, Liu Q, Zhao L, Shen Z, Liu S, Xu B.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.1c00613

Bibliografisk träff 2020-09-12

Discovery of <i>N</i>-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors-Design, Synthesis, <i>In Vivo</i> Glucose Lowering Effects, and X-ray Crystal Complex Analysis.

Zhou J, Bie J, Wang X, Liu Q, Li R, Chen H, Hu J, Cao H, Ji W, Li Y, Liu S, Shen Z, Xu B.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.0c00726

Bibliografisk träff 2017-09-21

Fructose-1,6-bisphosphatase inhibitors: A new valid approach for management of type 2 diabetes mellitus.

Kaur R, Dahiya L, Kumar M.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2017.09.029

Bibliografisk träff 2010-12-02

Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase.

Dang Q, Liu Y, Cashion DK, Kasibhatla SR, Jiang T, Taplin F, Jacintho JD, Li H, Sun Z, Fan Y, DaRe J, Tian F, Li W, Gibson T, Lemus R, van Poelje PD, Potter SC, Erion MD.

J Med Chem · journal article · DOI 10.1021/jm101035x

Bibliografisk träff 2010-01-01

Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5'-adenosinemonophosphate (AMP) mimics.

Dang Q, Kasibhatla SR, Xiao W, Liu Y, Dare J, Taplin F, Reddy KR, Scarlato GR, Gibson T, van Poelje PD, Potter SC, Erion MD.

J Med Chem · journal article · DOI 10.1021/jm901420x

Bibliografisk träff 2009-12-21

Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors.

Tsukada T, Takahashi M, Takemoto T, Kanno O, Yamane T, Kawamura S, Nishi T.

Bioorg Med Chem Lett · comparative study; journal article · DOI 10.1016/j.bmcl.2009.12.056

Bibliografisk träff 2009-08-27

Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors.

Tsukada T, Takahashi M, Takemoto T, Kanno O, Yamane T, Kawamura S, Nishi T.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.08.081

Bibliografisk träff 2009-04-19

A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase.

Heng S, Gryncel KR, Kantrowitz ER.

Bioorg Med Chem · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2009.04.030

Bibliografisk träff 2008-06-21

Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors.

Dang Q, Kasibhatla SR, Jiang T, Fan K, Liu Y, Taplin F, Schulz W, Cashion DK, Reddy KR, van Poelje PD, Fujitaki JM, Potter SC, Erion MD.

J Med Chem · journal article · DOI 10.1021/jm8001235