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Publikationer i urvalet

10 träffar

Bibliografisk träff 2024-05-30

Systematic Structure-Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments.

St Onge CM, Pagare PP, Zheng Y, Arriaga M, Stevens DL, Mendez RE, Poklis JL, Halquist MS, Selley DE, Dewey WL, Banks ML, Zhang Y.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.4c00646

Bibliografisk träff 2017-06-12

Discovery of highly selective κ-opioid receptor agonists: 10α-Hydroxy TRK-820 derivatives.

Suzuki S, Sugawara Y, Tsuji R, Tanimura R, Kaneko C, Yuzawa N, Yagi M, Kawai K.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2017.06.017

Bibliografisk träff 2017-01-18

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.

Nagase H, Yamamoto N, Yata M, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Hirayama S, Kuroda D, Watanabe Y, Gouda H, Yanagisawa M.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.6b01418

Bibliografisk träff 2015-08-28

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain.

Nakajima R, Yamamoto N, Hirayama S, Iwai T, Saitoh A, Nagumo Y, Fujii H, Nagase H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2015.08.036

Bibliografisk träff 2012-10-30

The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives.

Nemoto T, Yamamoto N, Wada N, Harada Y, Tomatsu M, Ishihara M, Hirayama S, Iwai T, Fujii H, Nagase H.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2012.10.100

Bibliografisk träff 2012-10-05

Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies.

Fujii H, Imaide S, Hirayama S, Nemoto T, Gouda H, Hirono S, Nagase H.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2012.09.101

Bibliografisk träff 2012-06-07

Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies.

Nagase H, Imaide S, Hirayama S, Nemoto T, Fujii H.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2012.05.122

Bibliografisk träff 2012-03-02

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain.

Nagase H, Akiyama J, Nakajima R, Hirayama S, Nemoto T, Gouda H, Hirono S, Fujii H.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2012.02.082

Bibliografisk träff 2011-05-10

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1.

Yamamoto N, Fujii H, Nemoto T, Nakajima R, Momen S, Izumimoto N, Hasebe K, Mochizuki H, Nagase H.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2011.04.147

Bibliografisk träff 2008-09-09

Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists.

Kawai K, Hayakawa J, Miyamoto T, Imamura Y, Yamane S, Wakita H, Fujii H, Kawamura K, Matsuura H, Izumimoto N, Kobayashi R, Endo T, Nagase H.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2008.09.011