Pyridine alkaloids with activity in the central nervous system.
Lin SX, Curtis MA, Sperry J.
Bioorg Med Chem · research-article; review; journal article · DOI 10.1016/j.bmc.2020.115820 PUBLIKATIONSREGISTRET
Gå till forskningen.
Publikationsdata från Europe PMC och PubMed. Följ källhänvisningar från ämnesregistret till originalpublikationerna.
Publikationer som ChEBI hänvisar till för cytisinicline. Visa hela publikationsregistret
En publikationsträff är inte en slutsats. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.
Publikationer i urvalet
31 träffarAbsolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine.
Fitch RW, Snider BB, Zhou Q, Foxman BM, Pandya AA, Yakel JL, Olson TT, Al-Muhtasib N, Xiao Y, Welch KD, Panter KE.
J Nat Prod · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jnatprod.8b00062Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.
Yu LF, Zhang HK, Caldarone BJ, Eaton JB, Lukas RJ, Kozikowski AP.
J Med Chem · research support, non-u.s. gov't; review-article; review; journal article; research support, n.i.h., extramural · DOI 10.1021/jm401937aIdentification and synthesis of quinolizidines with anti-influenza a virus activity.
Dang Z, Jung K, Zhu L, Lai W, Xie H, Lee KH, Huang L, Chen CH.
ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml500236nThe 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: carboxamide derivatives with different spacer motifs.
Eibl C, Munoz L, Tomassoli I, Stokes C, Papke RL, Gündisch D.
Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2013.09.060The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.
Eibl C, Tomassoli I, Munoz L, Stokes C, Papke RL, Gündisch D.
Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2013.09.059Structure-based identification of OATP1B1/3 inhibitors.
De Bruyn T, van Westen GJ, Ijzerman AP, Stieger B, de Witte P, Augustijns PF, Annaert PP.
Mol Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1124/mol.112.084152(+)-Laburnamine, a natural selective ligand and partial agonist for the α4β2 nicotinic receptor subtype.
Tasso B, Novelli F, Sparatore F, Fasoli F, Gotti C.
J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/np3007028Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.
Breining SR, Melvin M, Bhatti BS, Byrd GD, Kiser MN, Hepler CD, Hooker DN, Zhang J, Reynolds LA, Benson LR, Fedorov NB, Sidach SS, Mitchener JP, Lucero LM, Lukas RJ, Whiteaker P, Yohannes D.
J Med Chem · journal article · DOI 10.1021/jm3011299Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Brunhofer G, Fallarero A, Karlsson D, Batista-Gonzalez A, Shinde P, Gopi Mohan C, Vuorela P.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2012.09.040Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation.
Zaveri N, Jiang F, Olsen C, Polgar W, Toll L.
J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm1006148Identification of 9-fluoro substituted (-)-cytisine derivatives as ligands with high affinity for nicotinic receptors.
Houllier N, Gopisetti J, Lestage P, Lasne MC, Rouden J.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2010.09.017In silico characterization of cytisinoids docked into an acetylcholine binding protein.
Abin-Carriquiry JA, Zunini MP, Cassels BK, Wonnacott S, Dajas F.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2010.04.092Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes.
Dallanoce C, Frigerio F, Martelli G, Grazioso G, Matera C, Pomè DY, Pucci L, Clementi F, Gotti C, De Amici M.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2010.04.065Synthesis, binding, and modeling studies of new cytisine derivatives, as ligands for neuronal nicotinic acetylcholine receptor subtypes.
Tasso B, Canu Boido C, Terranova E, Gotti C, Riganti L, Clementi F, Artali R, Bombieri G, Meneghetti F, Sparatore F.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm900225jDeconstructing cytisine: The syntheses of (+/-)-cyfusine and (+/-)-cyclopropylcyfusine, fused ring analogs of cytisine.
Yohannes D, Procko K, Lebel LA, Fox CB, O'Neill BT.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.02.078Epibatidine isomers and analogues: structure-activity relationships.
White R, Malpass JR, Handa S, Richard Baker S, Broad LM, Folly L, Mogg A.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2006.08.049Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity.
Chellappan SK, Xiao Y, Tueckmantel W, Kellar KJ, Kozikowski AP.
J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm051196m3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation.
Coe JW, Brooks PR, Wirtz MC, Bashore CG, Bianco KE, Vetelino MG, Arnold EP, Lebel LA, Fox CB, Tingley FD, Schulz DW, Davis TI, Sands SB, Mansbach RS, Rollema H, O'Neill BT.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2005.08.035Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Jensen AA, Frølund B, Liljefors T, Krogsgaard-Larsen P.
J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/jm040219eIn pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine.
Coe JW, Vetelino MG, Bashore CG, Wirtz MC, Brooks PR, Arnold EP, Lebel LA, Fox CB, Sands SB, Davis TI, Schulz DW, Rollema H, Tingley FD, O'Neill BT.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2005.04.036Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation.
Coe JW, Brooks PR, Vetelino MG, Wirtz MC, Arnold EP, Huang J, Sands SB, Davis TI, Lebel LA, Fox CB, Shrikhande A, Heym JH, Schaeffer E, Rollema H, Lu Y, Mansbach RS, Chambers LK, Rovetti CC, Schulz DW, Tingley FD, O'Neill BT.
J Med Chem · journal article · DOI 10.1021/jm050069nHalogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors.
Fitch RW, Kaneko Y, Klaperski P, Daly JW, Seitz G, Gündisch D.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2004.11.073Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells.
Xiao Y, Baydyuk M, Wang HP, Davis HE, Kellar KJ.
Bioorg Med Chem Lett · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/j.bmcl.2003.09.1053D QSAR analyses-guided rational design of novel ligands for the (alpha4)2(beta2)3 nicotinic acetylcholine receptor.
Gohlke H, Schwarz S, Gündisch D, Tilotta MC, Weber A, Wegge T, Seitz G.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm020859mSynthesis and biological evaluation at nicotinic acetylcholine receptors of N-arylalkyl- and N-aryl-7-azabicyclo[2.2.1]heptanes.
Cheng J, Zhang C, Stevens ED, Izenwasser S, Wade D, Chen S, Paul D, Trudell ML.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm01035612-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization.
Efange SM, Tu Z, von Hohenberg K, Francesconi L, Howell RC, Rampersad MV, Todaro LJ, Papke RL, Kung MP.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm010129zSynthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors.
Doll F, Dolci L, Valette H, Hinnen F, Vaufrey F, Guenther I, Fuseau C, Coulon C, Bottlaender M, Crouzel C.
J Med Chem · journal article · DOI 10.1021/jm9910223Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Holladay MW, Dart MJ, Lynch JK.
J Med Chem · review; journal article · DOI 10.1021/jm970377oBinding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors.
Schmeller T, Sauerwein M, Sporer F, Wink M, Müller WE.
J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/np50111a026