Recent advances and challenges of revolutionizing drug-resistant tuberculosis treatment.
Wei X, Yue L, Zhao B, Jiang N, Lei H, Zhai X.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2024.116785 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
23 träffarInvestigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.
Malwal SR, Mazurek B, Ko J, Xie P, Barnes C, Varvitsiotis C, Zimmerman MD, Olatunji S, Lee J, Xie M, Sarathy J, Caffrey M, Strynadka NCJ, Dartois V, Dick T, Lee BNR, Russell DG, Oldfield E.
J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.3c00398Targeting mycobacterial membranes and membrane proteins: Progress and limitations.
Kumar G, Kapoor S.
Bioorg Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1016/j.bmc.2023.117212Tuberculosis Drug Discovery: Challenges and New Horizons.
Fernandes GFS, Thompson AM, Castagnolo D, Denny WA, Dos Santos JL.
J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.2c00227Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.
Zattoni IF, Delabio LC, Dutra JP, Kita DH, Scheiffer G, Hembecker M, Pereira GDS, Moure VR, Valdameri G.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2022.114346Tuberculosis drug discovery: Progression and future interventions in the wake of emerging resistance.
Perveen S, Kumari D, Singh K, Sharma R.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2021.114066Molecule Property Analyses of Active Compounds for <i>Mycobacterium tuberculosis</i>.
Makarov V, Salina E, Reynolds RC, Kyaw Zin PP, Ekins S.
J Med Chem · research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.9b02075Multi-target drugs active against leishmaniasis: A paradigm of drug repurposing.
Braga SS.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2019.111660Drug discovery in tuberculosis. New drug targets and antimycobacterial agents.
Campaniço A, Moreira R, Lopes F.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2018.03.020Polyamine-based analogs and conjugates as antikinetoplastid agents.
Jagu E, Pomel S, Pethe S, Loiseau PM, Labruère R.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2017.08.014Design and Synthesis of 1-((1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N'-((E)-3,7-dimethylocta-2,6-dienyl)ethane-1,2-diamine (SQ109) Pyrrole Hybrid Derivatives: Discovery of Potent Antitubercular Agents Effective against Multidrug-Resistant Mycobacteria.
Bhakta S, Scalacci N, Maitra A, Brown AK, Dasugari S, Evangelopoulos D, McHugh TD, Mortazavi PN, Twist A, Petricci E, Manetti F, Castagnolo D.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.6b00031Targeting the trehalose utilization pathways of <i>Mycobacterium tuberculosis</i>.
Thanna S, Sucheck SJ.
Medchemcomm · research-article; journal article · DOI 10.1039/c5md00376hSAR analysis of new anti-TB drugs currently in pre-clinical and clinical development.
Poce G, Cocozza M, Consalvi S, Biava M.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2014.08.066Multitarget drug discovery for tuberculosis and other infectious diseases.
Li K, Schurig-Briccio LA, Feng X, Upadhyay A, Pujari V, Lechartier B, Fontes FL, Yang H, Rao G, Zhu W, Gulati A, No JH, Cintra G, Bogue S, Liu YL, Molohon K, Orlean P, Mitchell DA, Freitas-Junior L, Ren F, Sun H, Jiang T, Li Y, Guo RT, Cole ST, Gennis RB, Crick DC, Oldfield E.
J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm500131sEfficient synthesis of new (R)-2-amino-1-butanol derived ureas, thioureas and acylthioureas and in vitro evaluation of their antimycobacterial activity.
Dobrikov GM, Valcheva V, Valcheva V, Nikolova Y, Ugrinova I, Pasheva E, Dimitrov V.
Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2013.02.034Head-to-head prenyl tranferases: anti-infective drug targets.
Lin FY, Liu YL, Li K, Cao R, Zhu W, Axelson J, Pang R, Oldfield E.
J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm300208pTuberculosis: the drug development pipeline at a glance.
Villemagne B, Crauste C, Flipo M, Baulard AR, Déprez B, Willand N.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2012.02.033Synthesis and in vitro antimycobacterial activity of compounds derived from (R)- and (S)-2-amino-1-butanol - The crucial role of the configuration.
Dobrikov GM, Valcheva V, Valcheva V, Stoilova-Disheva M, Momekov G, Tzvetkova P, Chimov A, Dimitrov V.
Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2011.11.035The many faces of the adamantyl group in drug design.
Liu J, Obando D, Liao V, Lifa T, Codd R.
Eur J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1016/j.ejmech.2011.01.047Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates.
Onajole OK, Govender P, van Helden PD, Kruger HG, Maguire GE, Wiid I, Govender T.
Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2010.01.046Pentacyclo-undecane derived cyclic tetra-amines: synthesis and evaluation as potent anti-tuberculosis agents.
Onajole OK, Govender K, Govender P, van Helden PD, Kruger HG, Maguire GE, Muthusamy K, Pillay M, Wiid I, Govender T.
Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2009.07.015Synthesis and evaluation of carbamate prodrugs of SQ109 as antituberculosis agents.
Meng Q, Luo H, Liu Y, Li W, Zhang W, Yao Q.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.03.091New drugs against tuberculosis: problems, progress, and evaluation of agents in clinical development.
van den Boogaard J, Kibiki GS, Kisanga ER, Boeree MJ, Aarnoutse RE.
Antimicrob Agents Chemother · review-article; review; journal article · DOI 10.1128/aac.00749-08