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Publikationer i urvalet

23 träffar

Bibliografisk träff 2024-04-06

Opportunities and perspectives of small molecular phosphodiesterase inhibitors in neurodegenerative diseases.

Li Q, Liao Q, Qi S, Huang H, He S, Lyu W, Liang J, Qin H, Cheng Z, Yu F, Dong X, Wang Z, Han L, Han Y.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2024.116386

Bibliografisk träff 2023-10-23

Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors.

Liu J, Zhang X, Chen G, Shao Q, Zou Y, Li Z, Su H, Li M, Xu Y.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.115893

Bibliografisk träff 2022-02-03

Therapeutic potential of phosphodiesterase inhibitors for cognitive amelioration in Alzheimer's disease.

Xi M, Sun T, Chai S, Xie M, Chen S, Deng L, Du K, Shen R, Sun H.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2022.114170

Bibliografisk träff 2021-05-27

Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug Discovery.

Sun J, Xiao Z, Haider A, Gebhard C, Xu H, Luo HB, Zhang HT, Josephson L, Wang L, Liang SH.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.1c00115

Bibliografisk träff 2020-08-11

Quinoline-Pyrazole Scaffold as a Novel Ligand of Galectin-3 and Suppressor of TREM2 Signaling.

Gabr M, Rehman AU, Chen HF.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.0c00330

Bibliografisk träff 2019-03-29

Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.

Huang YY, Yu YF, Zhang C, Chen Y, Zhou Q, Li Z, Zhou S, Li Z, Guo L, Wu D, Wu Y, Luo HB.

J Med Chem · research support, non-u.s. gov't; validation study; journal article · DOI 10.1021/acs.jmedchem.9b00224

Bibliografisk träff 2015-11-10

Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.

Raheem IT, Schreier JD, Fuerst J, Gantert L, Hostetler ED, Huszar S, Joshi A, Kandebo M, Kim SH, Li J, Ma B, McGaughey G, Sharma S, Shipe WD, Uslaner J, Vandeveer GH, Yan Y, Renger JJ, Smith SM, Coleman PJ, Cox CD.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2015.11.013

Bibliografisk träff 2015-06-15

BN/CC isosterism in borazaronaphthalenes towards phosphodiesterase 10A (PDE10A) inhibitors.

Vlasceanu A, Jessing M, Kilburn JP.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2015.06.019

Bibliografisk träff 2014-12-22

Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors.

Yang H, Murigi FN, Wang Z, Li J, Jin H, Tu Z.

Bioorg Med Chem Lett · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2014.12.054

Bibliografisk träff 2014-06-19

Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: part II.

Das S, Shelke DE, Harde RL, Avhad VB, Khairatkar-Joshi N, Gullapalli S, Gupta PK, Gandhi MN, Bhateja DK, Bajpai M, Joshi AA, Marathe MY, Gudi GS, Jadhav SB, Mahat MY, Thomas A.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2014.06.028

Bibliografisk träff 2014-05-09

Discovery of a potent, selective, and orally active phosphodiesterase 10A inhibitor for the potential treatment of schizophrenia.

Bartolomé-Nebreda JM, Delgado F, Martín-Martín ML, Martínez-Viturro CM, Pastor J, Tong HM, Iturrino L, Macdonald GJ, Sanderson W, Megens A, Langlois X, Somers M, Vanhoof G, Conde-Ceide S.

J Med Chem · journal article · DOI 10.1021/jm500073h

Bibliografisk träff 2014-03-28

Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: Part I.

Das S, Harde RL, Shelke DE, Khairatkar-Joshi N, Bajpai M, Sapalya RS, Surve HV, Gudi GS, Pattem R, Behera DB, Jadhav SB, Thomas A.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2014.03.054

Bibliografisk träff 2014-03-26

Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate.

Fan J, Zhang X, Li J, Jin H, Padakanti PK, Jones LA, Flores HP, Su Y, Perlmutter JS, Tu Z.

Bioorg Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2014.03.028

Bibliografisk träff 2013-07-23

N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors.

Kilburn JP, Kehler J, Langgård M, Erichsen MN, Leth-Petersen S, Larsen M, Christoffersen CT, Nielsen J.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2013.07.030

Bibliografisk träff 2012-08-14

Current landscape of phosphodiesterase 10A (PDE10A) inhibition.

Chappie TA, Helal CJ, Hou X.

J Med Chem · journal article · DOI 10.1021/jm3004976

Bibliografisk träff 2012-07-27

Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.

Raheem IT, Breslin MJ, Fandozzi C, Fuerst J, Hill N, Huszar S, Kandebo M, Kim SH, Ma B, McGaughey G, Renger JJ, Schreier JD, Sharma S, Smith S, Uslaner J, Yan Y, Coleman PJ, Cox CD.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2012.07.072

Bibliografisk träff 2012-05-11

Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer.

Hu E, Ma J, Biorn C, Lester-Zeiner D, Cho R, Rumfelt S, Kunz RK, Nixey T, Michelsen K, Miller S, Shi J, Wong J, Hill Della Puppa G, Able J, Talreja S, Hwang DR, Hitchcock SA, Porter A, Immke D, Allen JR, Treanor J, Chen H.

J Med Chem · journal article · DOI 10.1021/jm3002372

Bibliografisk träff 2011-08-02

Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging.

Andrés JI, De Angelis M, Alcázar J, Iturrino L, Langlois X, Dedeurwaerdere S, Lenaerts I, Vanhoof G, Celen S, Bormans G.

J Med Chem · journal article · DOI 10.1021/jm200536d

Bibliografisk träff 2011-06-12

Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A.

Zhang Z, Lu X, Xu J, Rothfuss J, Mach RH, Tu Z.

Eur J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ejmech.2011.05.072

Bibliografisk träff 2011-04-30

Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors.

Kehler J, Ritzen A, Langgård M, Petersen SL, Farah MM, Bundgaard C, Christoffersen CT, Nielsen J, Kilburn JP.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2011.04.067

Bibliografisk träff 2010-06-01

Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.

Höfgen N, Stange H, Schindler R, Lankau HJ, Grunwald C, Langen B, Egerland U, Tremmel P, Pangalos MN, Marquis KL, Hage T, Harrison BL, Malamas MS, Brandon NJ, Kronbach T.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm1002793

Bibliografisk träff 2009-12-01

Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy.

Verhoest PR, Proulx-Lafrance C, Corman M, Chenard L, Helal CJ, Hou X, Kleiman R, Liu S, Marr E, Menniti FS, Schmidt CJ, Vanase-Frawley M, Schmidt AW, Williams RD, Nelson FR, Fonseca KR, Liras S.

J Med Chem · journal article · DOI 10.1021/jm9015334

Bibliografisk träff 2009-08-01

Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia.

Verhoest PR, Chapin DS, Corman M, Fonseca K, Harms JF, Hou X, Marr ES, Menniti FS, Nelson F, O'Connor R, Pandit J, Proulx-Lafrance C, Schmidt AW, Schmidt CJ, Suiciak JA, Liras S.

J Med Chem · journal article · DOI 10.1021/jm900521k