Drug development and potential targets for Cushing's syndrome.
Wei W, Xu Q, Wu L, Gong G, Tian Y, Huang H, Li Z.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2024.116333 PUBLIKATIONSREGISTRET
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Rak M, Menge A, Tesch R, Berger LM, Balourdas DI, Shevchenko E, Krämer A, Elson L, Berger BT, Abdi I, Wahl LM, Poso A, Kaiser A, Hanke T, Kronenberger T, Joerger AC, Müller S, Knapp S.
J Med Chem · journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.3c02217Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3.
Amrhein JA, Berger LM, Balourdas DI, Joerger AC, Menge A, Krämer A, Frischkorn JM, Berger BT, Elson L, Kaiser A, Schubert-Zsilavecz M, Müller S, Knapp S, Hanke T.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.3c01980Interrogation of the Pathogen Box reveals small molecule ligands against the mycobacterial trehalose transporter LpqY-SugABC.
Radhakrishnan A, Brown CM, Guy CS, Cooper C, Pacheco-Gomez R, Stansfeld PJ, Fullam E.
RSC Med Chem · research-article; journal article · DOI 10.1039/d2md00104gMedulloblastoma drugs in development: Current leads, trials and drawbacks.
Wen J, Hadden MK.
Eur J Med Chem · research-article; review; journal article · DOI 10.1016/j.ejmech.2021.113268A comprehensive insight on the recent development of Cyclic Dependent Kinase inhibitors as anticancer agents.
Marak BN, Dowarah J, Khiangte L, Singh VP.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2020.112571Structure-activity relationships of Wee1 inhibitors: A review.
Du X, Li J, Luo X, Li R, Li F, Zhang Y, Shi J, He J.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2020.112524Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update.
Tadesse S, Caldon EC, Tilley W, Wang S.
J Med Chem · review; journal article · DOI 10.1021/acs.jmedchem.8b01469Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery.
Veale CGL, Hoppe HC.
Medchemcomm · research-article; journal article · DOI 10.1039/c8md00319jHow Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?
Jorda R, Hendrychová D, Voller J, Řezníčková E, Gucký T, Kryštof V.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.8b00049The target landscape of clinical kinase drugs.
Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Depaolini SR, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, Tõnisson N, Kramer K, Götze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, Médard G, Jeremias I, Spiekermann K, Kuster B.
Science · research support, non-u.s. gov't; research-article; journal article · DOI 10.1126/science.aan4368Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.
Zhu JY, Cuellar RA, Berndt N, Lee HE, Olesen SH, Martin MP, Jensen JT, Georg GI, Schönbrunn E.
J Med Chem · research-article; journal article · DOI 10.1021/acs.jmedchem.7b00996Structural insights of cyclin dependent kinases: Implications in design of selective inhibitors.
Kalra S, Joshi G, Munshi A, Kumar R.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2017.08.071Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor.
Valenciano AL, Ramsey AC, Santos WL, Mackey ZB.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2016.07.069Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor.
Brasca MG, Amboldi N, Ballinari D, Cameron A, Casale E, Cervi G, Colombo M, Colotta F, Croci V, D'Alessio R, Fiorentini F, Isacchi A, Mercurio C, Moretti W, Panzeri A, Pastori W, Pevarello P, Quartieri F, Roletto F, Traquandi G, Vianello P, Vulpetti A, Ciomei M.
J Med Chem · journal article · DOI 10.1021/jm9006559