Small molecule NS5B RdRp non-nucleoside inhibitors for the treatment of HCV infection: A medicinal chemistry perspective.
Zhou Z, Zhang J, Zhou E, Ren C, Wang J, Wang Y.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2022.114595 PUBLIKATIONSREGISTRET
Gå till forskningen.
Publikationsdata från Europe PMC och PubMed. Följ källhänvisningar från ämnesregistret till originalpublikationerna.
Publikationer som ChEBI hänvisar till för nesbuvir. Visa hela publikationsregistret
En publikationsträff är inte en slutsats. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.
Publikationer i urvalet
16 träffarDiscovery of novel potent HCV NS5B polymerase non-nucleoside inhibitors bearing a fused benzofuran scaffold.
Zhong M, Peng E, Huang N, Huang Q, Huq A, Lau M, Colonno R, Li L.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2018.01.029Synthesis and Anti-HCV Activity of 4-Hydroxyamino α-Pyranone Carboxamide Analogues.
Konreddy AK, Toyama M, Ito W, Bal C, Baba M, Sharon A.
ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml400432fDiscovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.
Maynard A, Crosby RM, Ellis B, Hamatake R, Hong Z, Johns BA, Kahler KM, Koble C, Leivers A, Leivers MR, Mathis A, Peat AJ, Pouliot JJ, Roberts CD, Samano V, Schmidt RM, Smith GK, Spaltenstein A, Stewart EL, Thommes P, Turner EM, Voitenleitner C, Walker JT, Waitt G, Weatherhead J, Weaver K, Williams S, Wright L, Xiong ZZ, Haigh D, Shotwell JB.
J Med Chem · journal article · DOI 10.1021/jm400317wHepatitis C replication inhibitors that target the viral NS4B protein.
Miller JF, Chong PY, Shotwell JB, Catalano JG, Tai VW, Fang J, Banka AL, Roberts CD, Youngman M, Zhang H, Xiong Z, Mathis A, Pouliot JJ, Hamatake RK, Price DJ, Seal JW, Stroup LL, Creech KL, Carballo LH, Todd D, Spaltenstein A, Furst S, Hong Z, Peat AJ.
J Med Chem · journal article · DOI 10.1021/jm400125hInhibitors for the hepatitis C virus RNA polymerase explored by SAR with advanced machine learning methods.
Weidlich IE, Filippov IV, Brown J, Kaushik-Basu N, Krishnan R, Nicklaus MC, Thorpe IF.
Bioorg Med Chem · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2013.03.032Hepatitis C RNA-dependent RNA polymerase inhibitors: a review of structure-activity and resistance relationships; different scaffolds and mutations.
Mayhoub AS.
Bioorg Med Chem · review; journal article · DOI 10.1016/j.bmc.2012.03.049Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase.
Cheng CC, Huang X, Shipps GW, Wang YS, Wyss DF, Soucy KA, Jiang CK, Agrawal S, Ferrari E, He Z, Huang HC.
ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml100128hDesign and synthesis of HCV agents with sequential triple inhibitory potentials.
Zhu T, Fawzi MB, Flint M, Kong F, Szeliga J, Tsao R, Howe AY, Pan W.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2010.06.156Novel hepatitis C virus reporter replicon cell lines enable efficient antiviral screening against genotype 1a.
Robinson M, Yang H, Sun SC, Peng B, Tian Y, Pagratis N, Greenstein AE, Delaney WE.
Antimicrob Agents Chemother · research-article; evaluation study; journal article · DOI 10.1128/aac.00289-10Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides.
Cheng CC, Shipps GW, Yang Z, Kawahata N, Lesburg CA, Duca JS, Bandouveres J, Bracken JD, Jiang CK, Agrawal S, Ferrari E, Huang HC.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2010.02.054GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796.
McCown MF, Rajyaguru S, Kular S, Cammack N, Nájera I.
Antimicrob Agents Chemother · research-article; journal article · DOI 10.1128/aac.01598-08Selection and characterization of hepatitis C virus replicons dually resistant to the polymerase and protease inhibitors HCV-796 and boceprevir (SCH 503034).
Flint M, Mullen S, Deatly AM, Chen W, Miller LZ, Ralston R, Broom C, Emini EA, Howe AY.
Antimicrob Agents Chemother · research-article; journal article · DOI 10.1128/aac.01081-08Development of intergenotypic chimeric replicons to determine the broad-spectrum antiviral activities of hepatitis C virus polymerase inhibitors.
Herlihy KJ, Graham JP, Kumpf R, Patick AK, Duggal R, Shi ST.
Antimicrob Agents Chemother · research-article; journal article · DOI 10.1128/aac.00533-08Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors.
Paeshuyse J, Vliegen I, Coelmont L, Leyssen P, Tabarrini O, Herdewijn P, Mittendorfer H, Easmon J, Cecchetti V, Bartenschlager R, Puerstinger G, Neyts J.
Antimicrob Agents Chemother · comparative study; research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.01534-07The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors.
McCown MF, Rajyaguru S, Le Pogam S, Ali S, Jiang WR, Kang H, Symons J, Cammack N, Najera I.
Antimicrob Agents Chemother · research-article; journal article · DOI 10.1128/aac.01317-07