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Publikationer i urvalet

16 träffar

Bibliografisk träff 2024-08-12

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.

Ashton TD, Calic PPS, Dans MG, Ooi ZK, Zhou Q, Palandri J, Loi K, Jarman KE, Qiu D, Lehane AM, Maity BC, De N, Giannangelo C, MacRaild CA, Creek DJ, Mao EY, Gancheva MR, Wilson DW, Chowdury M, de Koning-Ward TF, Famodimu MT, Delves MJ, Pollard H, Sutherland CJ, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.4c01241

Bibliografisk träff 2023-05-20

Recent developments in antimalarial drug discovery.

Umumararungu T, Nkuranga JB, Habarurema G, Nyandwi JB, Mukazayire MJ, Mukiza J, Muganga R, Hahirwa I, Mpenda M, Katembezi AN, Olawode EO, Kayitare E, Kayumba PC.

Bioorg Med Chem · review; journal article · DOI 10.1016/j.bmc.2023.117339

Bibliografisk träff 2023-03-11

Current development of β-carboline derived potential antimalarial scaffolds.

Kushwaha P, Kumar V, Saha B.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2023.115247

Bibliografisk träff 2022-03-28

Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity.

Lopes EA, Mestre R, Fontinha D, Legac J, Pei JV, Sanches-Vaz M, Mori M, Lehane AM, Rosenthal PJ, Prudêncio M, Santos MMM.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114324

Bibliografisk träff 2020-10-22

An insight into the recent development of the clinical candidates for the treatment of malaria and their target proteins.

Madhav H, Hoda N.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2020.112955

Bibliografisk träff 2019-09-19

Recent progress on anti-Toxoplasma drugs discovery: Design, synthesis and screening.

Deng Y, Wu T, Zhai SQ, Li CH.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2019.111711

Bibliografisk träff 2019-08-20

The Development Process for Discovery and Clinical Advancement of Modern Antimalarials.

Ashton TD, Devine SM, Möhrle JJ, Laleu B, Burrows JN, Charman SA, Creek DJ, Sleebs BE.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.9b00761

Bibliografisk träff 2019-06-24

New dimensions in the field of antimalarial research against malaria resurgence.

Narula AK, Azad CS, Nainwal LM.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2019.05.043

Bibliografisk träff 2018-04-27

Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ <sup>null</sup> Mouse Model of Malaria.

Nchinda AT, Le Manach C, Paquet T, Gonzàlez Cabrera D, Wicht KJ, Brunschwig C, Njoroge M, Abay E, Taylor D, Lawrence N, Wittlin S, Jiménez-Díaz MB, Santos Martínez M, Ferrer S, Angulo-Barturen I, Lafuente-Monasterio MJ, Duffy J, Burrows J, Street LJ, Chibale K, Chibale K.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.8b00382

Bibliografisk träff 2014-03-18

Synthetic indole and melatonin derivatives exhibit antimalarial activity on the cell cycle of the human malaria parasite Plasmodium falciparum.

Schuck DC, Jordão AK, Nakabashi M, Cunha AC, Ferreira VF, Garcia CR.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2014.03.055

Bibliografisk träff 2013-10-01

Pharmacokinetics, metabolism, and <i>in vivo</i> efficacy of the antimalarial natural product bromophycolide A.

Teasdale ME, Prudhomme J, Torres M, Braley M, Cervantes S, Bhatia SC, La Clair JJ, Le Roch K, Kubanek J.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml4002858

Bibliografisk träff 2013-09-13

Cell-based medicinal chemistry optimization of high-throughput screening (HTS) hits for orally active antimalarials. Part 1: challenges in potency and absorption, distribution, metabolism, excretion/pharmacokinetics (ADME/PK).

Chatterjee AK.

J Med Chem · review; journal article · DOI 10.1021/jm400314m

Bibliografisk träff 2013-09-06

Using genetic methods to define the targets of compounds with antimalarial activity.

Flannery EL, Fidock DA, Winzeler EA.

J Med Chem · research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1021/jm400325j

Bibliografisk träff 2013-03-27

Recent advances in malaria drug discovery.

Biamonte MA, Wanner J, Le Roch KG.

Bioorg Med Chem Lett · research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2013.03.067

Bibliografisk träff 2010-09-01

Spiroindolones, a potent compound class for the treatment of malaria.

Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler EA, Diagana TT.

Science · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1126/science.1193225

Bibliografisk träff 2010-07-01

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

Yeung BK, Zou B, Rottmann M, Lakshminarayana SB, Ang SH, Leong SY, Tan J, Wong J, Keller-Maerki S, Fischli C, Goh A, Schmitt EK, Krastel P, Francotte E, Kuhen K, Plouffe D, Henson K, Wagner T, Winzeler EA, Petersen F, Brun R, Dartois V, Diagana TT, Keller TH.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm100410f