Recent updates for designing CCR5 antagonists as anti-retroviral agents.
Shah HR, Savjani JK.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2018.01.085 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
8 träffarStructural Analysis of Chemokine Receptor-Ligand Interactions.
Arimont M, Sun SL, Leurs R, Smit M, de Esch IJP, de Graaf C.
J Med Chem · research support, non-u.s. gov't; review-article; review; journal article · DOI 10.1021/acs.jmedchem.6b01309DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.
Drug Discov Today · review; journal article · DOI 10.1016/j.drudis.2016.02.015Chemokine receptor antagonists.
Pease J, Horuk R.
J Med Chem · journal article · DOI 10.1021/jm300682jTranslating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.
PLoS Comput Biol · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1371/journal.pcbi.1002310FDA-approved drug labeling for the study of drug-induced liver injury.
Chen M, Vijay V, Shi Q, Liu Z, Fang H, Tong W.
Drug Discov Today · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/j.drudis.2011.05.007An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798).
Stupple PA, Batchelor DV, Corless M, Dorr PK, Ellis D, Fenwick DR, Galan SR, Jones RM, Mason HJ, Middleton DS, Perros M, Perruccio F, Platts MY, Pryde DC, Rodrigues D, Smith NN, Stephenson PT, Webster R, Westby M, Wood A.
J Med Chem · journal article · DOI 10.1021/jm100978nHepatotoxicity observed in clinical trials of aplaviroc (GW873140).
Nichols WG, Steel HM, Bonny T, Adkison K, Curtis L, Millard J, Kabeya K, Clumeck N.
Antimicrob Agents Chemother · clinical trial, phase ii; research-article; multicenter study; randomized controlled trial; journal article · DOI 10.1128/aac.00821-07