A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives.
Gu J, Wu Q, Zhang Q, You Q, Wang L.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2022.114742 PUBLIKATIONSREGISTRET
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Eur J Med Chem · research-article; journal article · DOI 10.1016/j.ejmech.2021.113485Tricyclononene carboxamide derivatives as novel anti-HIV-1 agents.
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Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2010.05.070Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects.
Jordan R, Chinsangaram J, Bolken TC, Tyavanagimatt SR, Tien D, Jones KF, Frimm A, Corrado ML, Pickens M, Landis P, Clarke J, Marbury TC, Hruby DE.
Antimicrob Agents Chemother · research-article; clinical trial, phase i; randomized controlled trial; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1128/aac.01689-09ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation.
Berhanu A, King DS, Mosier S, Jordan R, Jones KF, Hruby DE, Grosenbach DW.
Antimicrob Agents Chemother · research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.00678-09Antiviral evaluation of N-amino-1,2,3-triazoles against Cantagalo virus replication in cell culture.
Jordão AK, Afonso PP, Ferreira VF, de Souza MC, Almeida MC, Beltrame CO, Paiva DP, Wardell SM, Wardell JL, Tiekink ER, Damaso CR, Cunha AC.
Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2009.04.046Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.
Huggins J, Goff A, Hensley L, Mucker E, Shamblin J, Wlazlowski C, Johnson W, Chapman J, Larsen T, Twenhafel N, Karem K, Damon IK, Byrd CM, Bolken TC, Jordan R, Hruby D.
Antimicrob Agents Chemother · research-article; journal article · DOI 10.1128/aac.00021-09ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification.
Jordan R, Goff A, Frimm A, Corrado ML, Hensley LE, Byrd CM, Mucker E, Shamblin J, Bolken TC, Wlazlowski C, Johnson W, Chapman J, Twenhafel N, Tyavanagimatt S, Amantana A, Chinsangaram J, Hruby DE, Huggins J.
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Kern ER, Prichard MN, Quenelle DC, Keith KA, Tiwari KN, Maddry JA, Secrist JA.
Antimicrob Agents Chemother · research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.01257-08Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor.
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Antimicrob Agents Chemother · research-article; clinical trial, phase i; randomized controlled trial; journal article · DOI 10.1128/aac.01303-07Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses.
Quenelle DC, Prichard MN, Keith KA, Hruby DE, Jordan R, Painter GR, Robertson A, Kern ER.
Antimicrob Agents Chemother · research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.00762-07Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice.
Quenelle DC, Buller RM, Parker S, Keith KA, Hruby DE, Jordan R, Kern ER.
Antimicrob Agents Chemother · research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.00879-06