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Publikationer i urvalet

15 träffar

Bibliografisk träff 2021-08-10

Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.

Vachal P, Duffy JL, Campeau LC, Amin RP, Mitra K, Murphy BA, Shao PP, Sinclair PJ, Ye F, Katipally R, Lu Z, Ondeyka D, Chen YH, Zhao K, Sun W, Tyagarajan S, Bao J, Wang SP, Cote J, Lipardi C, Metzger D, Leung D, Hartmann G, Wollenberg GK, Liu J, Tan L, Xu Y, Chen Q, Liu G, Blaustein RO, Johns DG.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.1c00959

Bibliografisk träff 2020-11-06

Cholesteryl ester transfer protein (CETP) inhibitors based on cyclic urea, bicyclic urea and bicyclic sulfamide cores.

Liu J, Shao PP, Guiadeen D, Krikorian A, Sun W, Deng Q, Cumiskey AM, Duffy RA, Murphy BA, Mitra K, Johns DG, Duffy JL, Vachal P.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2020.127668

Bibliografisk träff 2020-03-17

Metabolic and Pharmaceutical Aspects of Fluorinated Compounds.

Johnson BM, Shu YZ, Zhuo X, Meanwell NA.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.9b01877

Bibliografisk träff 2019-11-17

Synthesis, biological evaluation and SAR studies of ursolic acid 3β-ester derivatives as novel CETP inhibitors.

Chen C, Sun R, Sun Y, Chen X, Li F, Wen X, Yuan H, Chen D.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2019.126824

Bibliografisk träff 2017-11-17

Relevance of Half-Life in Drug Design.

Smith DA, Beaumont K, Maurer TS, Di L.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.7b00969

Bibliografisk träff 2017-10-16

Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma.

Yamada K, Brousseau M, Honma W, Iimura A, Imase H, Iwaki Y, Kawanami T, LaSala D, Liang G, Mitani H, Nonomura K, Ohmori O, Pan M, Rigel DF, Umemura I, Yasoshima K, Zhu G, Mogi M.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.7b00900

Bibliografisk träff 2017-08-04

Discovery of pentacyclic triterpene 3β-ester derivatives as a new class of cholesterol ester transfer protein inhibitors.

Chen D, Huang X, Zhou H, Luo H, Wang P, Chang Y, He X, Ni S, Shen Q, Cao G, Sun H, Wen X, Liu J.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.08.012

Bibliografisk träff 2016-09-30

Fragment-based discovery of novel pentacyclic triterpenoid derivatives as cholesteryl ester transfer protein inhibitors.

Chang Y, Zhou S, Li E, Zhao W, Ji Y, Wen X, Sun H, Yuan H.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.09.098

Bibliografisk träff 2016-07-27

Design, synthesis and biological evaluation of novel cholesteryl ester transfer protein inhibitors bearing a cycloalkene scaffold.

Liu C, Luo C, Hao L, Wu Q, Xie H, Zhao S, Hao C, Zhao D, Cheng M.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.07.065

Bibliografisk träff 2016-03-02

Discovery of novel N,N-3-phenyl-3-benzylaminopropionanilides as potent inhibitors of cholesteryl ester transfer protein in vivo.

Xie H, Li Y, Bai C, Wang R, Liu C, Hao C, Lin B, Cheng M, Zhao D.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2016.03.002

Bibliografisk träff 2015-06-18

Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activities.

Wang W, He Y, Xu P, You Q, Xiao H, Xiang H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2015.06.032

Bibliografisk träff 2014-10-27

Potent cholesteryl ester transfer protein inhibitors of reduced lipophilicity: 1,1'-spiro-substituted hexahydrofuroquinoline derivatives.

Trieselmann T, Wagner H, Fuchs K, Hamprecht D, Berta D, Cremonesi P, Streicher R, Luippold G, Volz A, Markert M, Nar H.

J Med Chem · journal article · DOI 10.1021/jm500431d

Bibliografisk träff 2012-03-28

Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors.

Fernandez MC, Escribano A, Mateo AI, Parthasarathy S, Martin de la Nava EM, Wang X, Cockerham SL, Beyer TP, Schmidt RJ, Cao G, Zhang Y, Jones TM, Borel A, Sweetana SA, Cannady EA, Stephenson G, Frank S, Mantlo NB.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2012.03.075

Bibliografisk träff 2011-11-16

SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors.

Lu Z, Chen YH, Napolitano JB, Taylor G, Ali A, Hammond ML, Deng Q, Tan E, Tong X, Xu SS, Latham MJ, Peterson LB, Anderson MS, Eveland SS, Guo Q, Hyland SA, Milot DP, Chen Y, Sparrow CP, Wright SD, Sinclair PJ.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2011.11.039

Bibliografisk träff 2011-06-17

Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib.

Smith CJ, Ali A, Hammond ML, Li H, Lu Z, Napolitano J, Taylor GE, Thompson CF, Anderson MS, Chen Y, Eveland SS, Guo Q, Hyland SA, Milot DP, Sparrow CP, Wright SD, Cumiskey AM, Latham M, Peterson LB, Rosa R, Pivnichny JV, Tong X, Xu SS, Sinclair PJ.

J Med Chem · journal article · DOI 10.1021/jm200484c