ActiQs / Forskning

PUBLIKATIONSREGISTRET

Gå till forskningen.

Publikationsdata från Europe PMC och PubMed. Följ källhänvisningar från ämnesregistret till originalpublikationerna.

Publikationer som ChEBI hänvisar till för btz-043. Visa hela publikationsregistret

En publikationsträff är inte en slutsats. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.

Publikationer i urvalet

36 träffar

Bibliografisk träff 2023-12-29

Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway.

Karabanovich G, Fabiánová V, Vocat A, Dušek J, Valášková L, Stolaříková J, Kitson RRA, Pávek P, Vávrová K, Djaout K, Mikušová K, Baulard AR, Cole ST, Korduláková J, Roh J.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.3c00925

Bibliografisk träff 2023-12-03

Whole cell hydride Meisenheimer complex biotransformation guided optimization of antimycobacterial benzothiazinones.

Joch M, Wojtas KP, Torres-Gómez H, Li Y, Meyer F, Straßburger M, Kerndl V, Dahse HM, Hertweck C, Hoffmann H, Görls H, Walter K, Hölscher C, Kloss F.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.116023

Bibliografisk träff 2023-07-03

2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1.

Finger V, Kucera T, Kafkova R, Muckova L, Dolezal R, Kubes J, Novak M, Prchal L, Lakatos L, Andrs M, Hympanova M, Marek J, Kufa M, Spiwok V, Soukup O, Mezeiova E, Janousek J, Nevosadova L, Benkova M, Kitson RRA, Kratky M, Bősze S, Mikusova K, Hartkoorn R, Roh J, Korabecny J.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.115611

Bibliografisk träff 2023-02-11

Targeting mycobacterial membranes and membrane proteins: Progress and limitations.

Kumar G, Kapoor S.

Bioorg Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1016/j.bmc.2023.117212

Bibliografisk träff 2022-05-25

Tuberculosis Drug Discovery: Challenges and New Horizons.

Fernandes GFS, Thompson AM, Castagnolo D, Denny WA, Dos Santos JL.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.2c00227

Bibliografisk träff 2021-12-26

Tuberculosis drug discovery: Progression and future interventions in the wake of emerging resistance.

Perveen S, Kumari D, Singh K, Sharma R.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2021.114066

Bibliografisk träff 2021-01-04

Hydride-induced Meisenheimer complex formation reflects activity of nitro aromatic anti-tuberculosis compounds.

Liu R, Markley L, Miller PA, Franzblau S, Shetye G, Ma R, Savková K, Mikušová K, Lee BS, Pethe K, Moraski GC, Miller MJ.

RSC Med Chem · research-article; journal article · DOI 10.1039/d0md00390e

Bibliografisk träff 2020-08-30

Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents.

Liu L, Kong C, Fumagalli M, Savková K, Xu Y, Huszár S, Sammartino JC, Fan D, Chiarelli LR, Mikušová K, Sun Z, Qiao C.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112773

Bibliografisk träff 2020-05-13

Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-β-d-Ribose Oxidase (DprE1) Inhibitors.

Balabon O, Pitta E, Rogacki MK, Meiler E, Casanueva R, Guijarro L, Huss S, Lopez-Roman EM, Santos-Villarejo Á, Augustyns K, Ballell L, Aguirre DB, Bates RH, Cunningham F, Cacho M, Van der Veken P.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.0c00107

Bibliografisk träff 2020-04-20

Molecule Property Analyses of Active Compounds for <i>Mycobacterium tuberculosis</i>.

Makarov V, Salina E, Reynolds RC, Kyaw Zin PP, Ekins S.

J Med Chem · research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.9b02075

Bibliografisk träff 2019-09-23

Scaffold Morphing To Identify Novel DprE1 Inhibitors with Antimycobacterial Activity.

R MM, Shandil R, Panda M, Sadler C, Ambady A, Panduga V, Kumar N, Mahadevaswamy J, Sreenivasaiah M, Narayan A, Guptha S, Sharma S, Sambandamurthy VK, Ramachandran V, Mallya M, Cooper C, Mdluli K, Butler S, Tommasi R, Iyer PS, Narayanan S, Chatterji M, Shirude PS.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.9b00343

Bibliografisk träff 2019-08-29

Deuteration of BTZ043 Extends the Lifetime of Meisenheimer Intermediates to the Antituberculosis Nitroso Oxidation State.

Liu R, Krchnak V, Brown SN, Miller MJ.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.9b00308

Bibliografisk träff 2019-08-22

Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2'-Oxidase.

Karabanovich G, Dušek J, Savková K, Pavliš O, Pávková I, Korábečný J, Kučera T, Kočová Vlčková H, Huszár S, Konyariková Z, Konečná K, Jand'ourek O, Stolaříková J, Korduláková J, Vávrová K, Pávek P, Klimešová V, Hrabálek A, Mikušová K, Roh J.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.9b00912

Bibliografisk träff 2018-12-13

Identification and Profiling of Hydantoins-A Novel Class of Potent Antimycobacterial DprE1 Inhibitors.

Rogacki MK, Pitta E, Balabon O, Huss S, Lopez-Roman EM, Argyrou A, Blanco-Ruano D, Cacho M, Vande Velde CML, Augustyns K, Ballell L, Barros D, Bates RH, Cunningham F, Van der Veken P.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.8b01356

Bibliografisk träff 2018-11-05

Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.

Oh S, Park Y, Engelhart CA, Wallach JB, Schnappinger D, Arora K, Manikkam M, Gac B, Wang H, Murgolo N, Olsen DB, Goodwin M, Sutphin M, Weiner DM, Via LE, Boshoff HIM, Barry CE.

J Med Chem · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.8b00883

Bibliografisk träff 2018-09-17

Identification of novel benzothiopyranone compounds against Mycobacterium tuberculosis through scaffold morphing from benzothiazinones.

Li P, Wang B, Zhang X, Batt SM, Besra GS, Zhang T, Ma C, Zhang D, Lin Z, Li G, Huang H, Lu Y.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.09.042

Bibliografisk träff 2018-06-12

Overview of the Development of DprE1 Inhibitors for Combating the Menace of Tuberculosis.

Chikhale RV, Barmade MA, Murumkar PR, Yadav MR.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.8b00281

Bibliografisk träff 2018-03-09

Drug discovery in tuberculosis. New drug targets and antimycobacterial agents.

Campaniço A, Moreira R, Lopes F.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2018.03.020

Bibliografisk träff 2017-06-03

Drug development against tuberculosis: Impact of alkaloids.

Mishra SK, Tripathi G, Kishore N, Singh RK, Singh A, Tiwari VK.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2017.06.005

Bibliografisk träff 2016-11-21

S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.

Karabanovich G, Němeček J, Valášková L, Carazo A, Konečná K, Stolaříková J, Hrabálek A, Pavliš O, Pávek P, Vávrová K, Roh J, Klimešová V.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.11.041

Bibliografisk träff 2016-03-15

Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.

Karabanovich G, Zemanová J, Smutný T, Székely R, Šarkan M, Centárová I, Vocat A, Pávková I, Čonka P, Němeček J, Stolaříková J, Vejsová M, Vávrová K, Klimešová V, Hrabálek A, Pávek P, Cole ST, Mikušová K, Roh J.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.5b00608

Bibliografisk träff 2016-03-15

Synthesis and docking studies of pyrazine-thiazolidinone hybrid scaffold targeting dormant tuberculosis.

Chitre TS, Asgaonkar KD, Miniyar PB, Dharme AB, Arkile MA, Yeware A, Sarkar D, Khedkar VM, Jha PC.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2016.03.055

Bibliografisk träff 2016-02-27

Design, syntheses, and anti-tuberculosis activities of conjugates of piperazino-1,3-benzothiazin-4-ones (pBTZs) with 2,7-dimethylimidazo [1,2-a]pyridine-3-carboxylic acids and 7-phenylacetyl cephalosporins.

Majewski MW, Tiwari R, Miller PA, Cho S, Franzblau SG, Miller MJ.

Bioorg Med Chem Lett · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2016.02.076

Bibliografisk träff 2016-01-04

Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043.

Tiwari R, Miller PA, Chiarelli LR, Mori G, Šarkan M, Centárová I, Cho S, Mikušová K, Franzblau SG, Oliver AG, Miller MJ.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.5b00424

Bibliografisk träff 2015-10-05

Syntheses and Biological Evaluations of Highly Functionalized Hydroxamate Containing and <i>N</i>-Methylthio Monobactams as Anti-Tuberculosis and β-Lactamase Inhibitory Agents.

Majewski MW, Watson KD, Cho S, Miller PA, Franzblau SG, Miller MJ.

Medchemcomm · research-article; journal article · DOI 10.1039/c5md00340g

Bibliografisk träff 2014-11-29

Syntheses and Antituberculosis Activity of 1,3-Benzothiazinone Sulfoxide and Sulfone Derived from BTZ043.

Tiwari R, Miller PA, Cho S, Franzblau SG, Miller MJ.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml5003458

Bibliografisk träff 2014-08-27

SAR analysis of new anti-TB drugs currently in pre-clinical and clinical development.

Poce G, Cocozza M, Consalvi S, Biava M.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2014.08.066

Bibliografisk träff 2014-06-20

Lead optimization of 1,4-azaindoles as antimycobacterial agents.

Shirude PS, Shandil RK, Manjunatha MR, Sadler C, Panda M, Panduga V, Reddy J, Saralaya R, Nanduri R, Ambady A, Ravishankar S, Sambandamurthy VK, Humnabadkar V, Jena LK, Suresh RS, Srivastava A, Prabhakar KR, Whiteaker J, McLaughlin RE, Sharma S, Cooper CB, Mdluli K, Butler S, Iyer PS, Narayanan S, Chatterji M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm500571f

Bibliografisk träff 2014-06-11

4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity.

Naik M, Humnabadkar V, Tantry SJ, Panda M, Narayan A, Guptha S, Panduga V, Manjrekar P, Jena LK, Koushik K, Shanbhag G, Jatheendranath S, Manjunatha MR, Gorai G, Bathula C, Rudrapatna S, Achar V, Sharma S, Ambady A, Hegde N, Mahadevaswamy J, Kaur P, Sambandamurthy VK, Awasthy D, Narayan C, Ravishankar S, Madhavapeddi P, Reddy J, Prabhakar K, Saralaya R, Chatterji M, Whiteaker J, McLaughlin B, Chiarelli LR, Riccardi G, Pasca MR, Binda C, Neres J, Dhar N, Signorino-Gelo F, McKinney JD, Ramachandran V, Shandil R, Tommasi R, Iyer PS, Narayanan S, Hosagrahara V, Kavanagh S, Dinesh N, Ghorpade SR.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm5005978

Bibliografisk träff 2014-06-02

1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria.

Karabanovich G, Roh J, Smutný T, Němeček J, Vicherek P, Stolaříková J, Vejsová M, Dufková I, Vávrová K, Pávek P, Klimešová V, Hrabálek A.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2014.05.069