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Publikationer i urvalet

10 träffar

Bibliografisk träff 2021-06-24

Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205.

Woodley CM, Nixon GL, Basilico N, Parapini S, Hong WD, Ward SA, Biagini GA, Leung SC, Taramelli D, Onuma K, Hasebe T, O'Neill PM.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.1c00031

Bibliografisk träff 2020-10-22

An insight into the recent development of the clinical candidates for the treatment of malaria and their target proteins.

Madhav H, Hoda N.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2020.112955

Bibliografisk träff 2019-08-20

The Development Process for Discovery and Clinical Advancement of Modern Antimalarials.

Ashton TD, Devine SM, Möhrle JJ, Laleu B, Burrows JN, Charman SA, Creek DJ, Sleebs BE.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.9b00761

Bibliografisk träff 2017-07-10

Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane.

Blank BR, Gut J, Rosenthal PJ, Renslo AR.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.7b00699

Bibliografisk träff 2017-01-18

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).

Dong Y, Wang X, Kamaraj S, Bulbule VJ, Chiu FC, Chollet J, Dhanasekaran M, Hein CD, Papastogiannidis P, Morizzi J, Shackleford DM, Barker H, Ryan E, Scheurer C, Tang Y, Zhao Q, Zhou L, White KL, Urwyler H, Charman WN, Matile H, Wittlin S, Charman SA, Vennerstrom JL.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.6b01586

Bibliografisk träff 2016-02-09

Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action.

Fernández-Álvaro E, Hong WD, Nixon GL, O'Neill PM, Calderón F.

J Med Chem · review; journal article · DOI 10.1021/acs.jmedchem.5b01485

Bibliografisk träff 2013-09-06

Using genetic methods to define the targets of compounds with antimalarial activity.

Flannery EL, Fidock DA, Winzeler EA.

J Med Chem · research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1021/jm400325j

Bibliografisk träff 2013-03-27

Recent advances in malaria drug discovery.

Biamonte MA, Wanner J, Le Roch KG.

Bioorg Med Chem Lett · research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2013.03.067

Bibliografisk träff 2013-03-15

Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.

Wang X, Dong Y, Wittlin S, Charman SA, Chiu FC, Chollet J, Katneni K, Mannila J, Morizzi J, Ryan E, Scheurer C, Steuten J, Santo Tomas J, Snyder C, Vennerstrom JL.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm400004u

Bibliografisk träff 2011-09-19

Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine.

Bousejra-El Garah F, Wong MH, Amewu RK, Muangnoicharoen S, Maggs JL, Stigliani JL, Park BK, Chadwick J, Ward SA, O'Neill PM.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm200768h