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Publikationer i urvalet

18 träffar

Bibliografisk träff 2023-01-13

A Quantum Mechanics-Based Method to Predict Intramolecular Hydrogen Bond Formation Reflecting P-glycoprotein Recognition.

Oguma T, Uehara S, Nakahara K, Okuyama Y, Fuchino K, Suzuki N, Kan Y, Kanegawa N, Ogata Y, Kusakabe KI.

ACS Med Chem Lett · brief-report; journal article · DOI 10.1021/acsmedchemlett.2c00427

Bibliografisk träff 2022-08-19

Design, synthesis and biological evaluation of novel coumarin derivatives as multifunctional ligands for the treatment of Alzheimer's disease.

Liu W, Wu L, Liu W, Tian L, Chen H, Wu Z, Wang N, Liu X, Qiu J, Feng X, Xu Z, Jiang X, Zhao Q.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114689

Bibliografisk träff 2021-06-03

Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor.

McKinzie DL, Winneroski LL, Green SJ, Hembre EJ, Erickson JA, Willis BA, Monk SA, Aluise CD, Baker TK, Lopez JE, Hendle J, Beck JP, Brier RA, Boggs LN, Borders AR, Cocke PJ, Garcia-Losada P, Lowe SL, Mathes BM, May PC, Porter WJ, Stout SL, Timm DE, Watson BM, Yang Z, Mergott DJ.

J Med Chem · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/acs.jmedchem.1c00489

Bibliografisk träff 2020-09-28

Meroterpenoids produced by fungi: Occurrence, structural diversity, biological activities, and their molecular targets.

Zhao M, Tang Y, Xie J, Zhao Z, Cui H.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2020.112860

Bibliografisk träff 2019-11-15

Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.

Winneroski LL, Erickson JA, Green SJ, Lopez JE, Stout SL, Porter WJ, Timm DE, Audia JE, Barberis M, Beck JP, Boggs LN, Borders AR, Boyer RD, Brier RA, Hembre EJ, Hendle J, Garcia-Losada P, Minguez JM, Mathes BM, May PC, Monk SA, Rankovic Z, Shi Y, Watson BM, Yang Z, Mergott DJ.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2019.115194

Bibliografisk träff 2019-10-28

Design, synthesis and evaluation of 2-amino-imidazol-4-one derivatives as potent β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) inhibitors.

Fan TY, Wu WY, Yu SP, Zhong Y, Zhao C, Chen M, Li HM, Li NG, Chen Z, Chen S, Sun ZH, Duan JA, Shi ZH.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2019.126772

Bibliografisk träff 2019-01-04

New evolutions in the BACE1 inhibitor field from 2014 to 2018.

Hsiao CC, Rombouts F, Gijsen HJM.

Bioorg Med Chem Lett · review; journal article · DOI 10.1016/j.bmcl.2018.12.049

Bibliografisk träff 2018-09-12

BACE1 Inhibitory Meroterpenoids from Aspergillus terreus.

Qi C, Liu M, Zhou Q, Gao W, Chen C, Lai Y, Hu Z, Xue Y, Zhang J, Li D, Li XN, Zhang Q, Wang J, Zhu H, Zhang Y.

J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jnatprod.7b01050

Bibliografisk träff 2018-08-25

Novel multi-target compounds in the quest for new chemotherapies against Alzheimer's disease: An experimental and theoretical study.

Martínez A, Zahran M, Gomez M, Cooper C, Guevara J, Ekengard E, Nordlander E, Alcendor R, Hambleton S.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2018.08.019

Bibliografisk träff 2018-05-17

Protoilludane, Illudalane, and Botryane Sesquiterpenoids from the Endophytic Fungus Phomopsis sp. TJ507A.

Xie S, Wu Y, Qiao Y, Guo Y, Wang J, Hu Z, Zhang Q, Li X, Huang J, Zhou Q, Luo Z, Liu J, Zhu H, Xue Y, Zhang Y.

J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jnatprod.7b00889

Bibliografisk träff 2018-04-17

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.

O'Neill BT, Beck EM, Butler CR, Nolan CE, Gonzales C, Zhang L, Doran SD, Lapham K, Buzon LM, Dutra JK, Barreiro G, Hou X, Martinez-Alsina LA, Rogers BN, Villalobos A, Murray JC, Ogilvie K, LaChapelle EA, Chang C, Lanyon LF, Steppan CM, Robshaw A, Hales K, Boucher GG, Pandher K, Houle C, Ambroise CW, Karanian D, Riddell D, Bales KR, Brodney MA.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.8b00246

Bibliografisk träff 2017-08-08

BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease.

Prati F, Bottegoni G, Bolognesi ML, Cavalli A.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.7b00393

Bibliografisk träff 2016-10-20

Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors.

Wu YJ, Guernon J, Rajamani R, Toyn JH, Ahlijanian MK, Albright CF, Muckelbauer J, Chang C, Camac D, Macor JE, Thompson LA.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2016.10.055

Bibliografisk träff 2016-01-11

Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents.

Wu YJ, Guernon J, Yang F, Snyder L, Shi J, Mcclure A, Rajamani R, Park H, Ng A, Lewis H, Chang C, Camac D, Toyn JH, Ahlijanian MK, Albright CF, Macor JE, Thompson LA.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.5b00432

Bibliografisk träff 2015-03-09

Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.

Butler CR, Brodney MA, Beck EM, Barreiro G, Nolan CE, Pan F, Vajdos F, Parris K, Varghese AH, Helal CJ, Lira R, Doran SD, Riddell DR, Buzon LM, Dutra JK, Martinez-Alsina LA, Ogilvie K, Murray JC, Young JM, Atchison K, Robshaw A, Gonzales C, Wang J, Zhang Y, O'Neill BT.

J Med Chem · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm501833t

Bibliografisk träff 2014-03-20

The evolution of amidine-based brain penetrant BACE1 inhibitors.

Oehlrich D, Prokopcova H, Gijsen HJ.

Bioorg Med Chem Lett · review; journal article · DOI 10.1016/j.bmcl.2014.03.025

Bibliografisk träff 2013-04-05

Structure-based design of β-site APP cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease.

Yuan J, Venkatraman S, Zheng Y, McKeever BM, Dillard LW, Singh SB.

J Med Chem · review; journal article · DOI 10.1021/jm301659n

Bibliografisk träff 2013-03-27

Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.

Trippier PC, Jansen Labby K, Hawker DD, Mataka JJ, Silverman RB.

J Med Chem · research-article; review; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm3015926