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Publikationer i urvalet

15 träffar

Bibliografisk träff 2024-04-02

Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction.

Lin Z, Liu C, Yan Z, Cheng J, Wang X, Zhou F, Lyu X, Zhang S, Zhang D, Meng X, Zhao Y.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2024.116366

Bibliografisk träff 2024-01-03

An overview of the functions of p53 and drugs acting either on wild- or mutant-type p53.

Huang Y, Jiao Z, Fu Y, Hou Y, Sun J, Hu F, Yu S, Gong K, Liu Y, Zhao G.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2024.116121

Bibliografisk träff 2023-12-07

Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy.

Cheng J, Yan Z, Jiang K, Liu C, Xu D, Lyu X, Hu X, Zhang S, Zhou Y, Li J, Zhao Y.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.3c01815

Bibliografisk träff 2021-10-29

Discovery of <b>MK-4688</b>: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction.

Reutershan MH, Machacek MR, Altman MD, Bogen S, Cai M, Cammarano C, Chen D, Christopher M, Cryan J, Daublain P, Fradera X, Geda P, Goldenblatt P, Hill AD, Kemper RA, Kutilek V, Li C, Martinez M, McCoy M, Nair L, Pan W, Thompson CF, Scapin G, Shizuka M, Spatz ML, Steinhuebel D, Sun B, Voss ME, Wang X, Yang L, Yeh TC, Dussault I, Marshall CG, Trotter BW.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c01524

Bibliografisk träff 2020-08-31

Opportunities for Tapping into Three-Dimensional Chemical Space through a Quaternary Carbon.

Talele TT.

J Med Chem · review; journal article · DOI 10.1021/acs.jmedchem.0c00829

Bibliografisk träff 2019-05-17

Development of selective small molecule MDM2 degraders based on nutlin.

Wang B, Wu S, Liu J, Yang K, Xie H, Tang W.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.05.046

Bibliografisk träff 2018-09-18

The development of piperidinones as potent MDM2-P53 protein-protein interaction inhibitors for cancer therapy.

Liao G, Yang D, Ma L, Li W, Hu L, Zeng L, Wu P, Duan L, Liu Z.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2018.09.044

Bibliografisk träff 2018-09-04

Role of p53 circuitry in tumorigenesis: A brief review.

Niazi S, Purohit M, Niazi JH.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2018.08.099

Bibliografisk träff 2018-04-18

Design, in silico prioritization and biological profiling of apoptosis-inducing lactams amenable by the Castagnoli-Cushman reaction.

Krasavin M, Gureyev MA, Dar'in D, Bakulina O, Chizhova M, Lepikhina A, Novikova D, Grigoreva T, Ivanov G, Zhumagalieva A, Garabadzhiu AV, Tribulovich VG.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2018.04.036

Bibliografisk träff 2017-03-24

Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development.

Aguilar A, Lu J, Liu L, Du D, Bernard D, McEachern D, Przybranowski S, Li X, Luo R, Wen B, Sun D, Wang H, Wen J, Wang G, Zhai Y, Guo M, Yang D, Wang S.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.6b01665

Bibliografisk träff 2016-12-14

Discovery of novel polycyclic spiro-fused carbocyclicoxindole-based anticancer agents.

Zhang L, Ren W, Wang X, Zhang J, Liu J, Zhao L, Zhang X.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.12.021

Bibliografisk träff 2014-11-14

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.

Zhao Y, Aguilar A, Bernard D, Wang S.

J Med Chem · research support, non-u.s. gov't; review-article; review; journal article; research support, n.i.h., extramural · DOI 10.1021/jm501092z

Bibliografisk träff 2014-03-27

Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.

Gonzalez AZ, Li Z, Beck HP, Canon J, Chen A, Chow D, Duquette J, Eksterowicz J, Fox BM, Fu J, Huang X, Houze J, Jin L, Li Y, Ling Y, Lo MC, Long AM, McGee LR, McIntosh J, Oliner JD, Osgood T, Rew Y, Saiki AY, Shaffer P, Wortman S, Yakowec P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Olson SH, Sun D, Medina JC.

J Med Chem · journal article · DOI 10.1021/jm401911v

Bibliografisk träff 2014-02-05

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.

Sun D, Li Z, Rew Y, Gribble M, Bartberger MD, Beck HP, Canon J, Chen A, Chen X, Chow D, Deignan J, Duquette J, Eksterowicz J, Fisher B, Fox BM, Fu J, Gonzalez AZ, Gonzalez-Lopez De Turiso F, Houze JB, Huang X, Jiang M, Jin L, Kayser F, Liu JJ, Lo MC, Long AM, Lucas B, McGee LR, McIntosh J, Mihalic J, Oliner JD, Osgood T, Peterson ML, Roveto P, Saiki AY, Shaffer P, Toteva M, Wang Y, Wang YC, Wortman S, Yakowec P, Yan X, Ye Q, Yu D, Yu M, Zhao X, Zhou J, Zhu J, Olson SH, Medina JC.

J Med Chem · journal article · DOI 10.1021/jm401753e

Bibliografisk träff 2013-03-16

Inhibitors of the p53/hdm2 protein-protein interaction-path to the clinic.

Carry JC, Garcia-Echeverria C.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2013.03.034