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Publikationer i urvalet

10 träffar

Bibliografisk träff 2022-04-14

Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.

Zhang S, Yan Z, Li Y, Gong Y, Lyu X, Lou J, Zhang D, Meng X, Zhao Y.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.2c00095

Bibliografisk träff 2022-04-08

Small-molecule MDM2 inhibitors in clinical trials for cancer therapy.

Wang S, Chen FE.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2022.114334

Bibliografisk träff 2021-10-29

Discovery of <b>MK-4688</b>: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction.

Reutershan MH, Machacek MR, Altman MD, Bogen S, Cai M, Cammarano C, Chen D, Christopher M, Cryan J, Daublain P, Fradera X, Geda P, Goldenblatt P, Hill AD, Kemper RA, Kutilek V, Li C, Martinez M, McCoy M, Nair L, Pan W, Thompson CF, Scapin G, Shizuka M, Spatz ML, Steinhuebel D, Sun B, Voss ME, Wang X, Yang L, Yeh TC, Dussault I, Marshall CG, Trotter BW.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c01524

Bibliografisk träff 2021-07-21

Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions.

Zhang S, Lou J, Li Y, Zhou F, Yan Z, Lyu X, Zhao Y.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.1c00940

Bibliografisk träff 2020-04-02

Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases.

Blaquiere N, Villemure E, Staben ST.

J Med Chem · review; journal article · DOI 10.1021/acs.jmedchem.9b01451

Bibliografisk träff 2014-03-27

Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.

Gonzalez AZ, Li Z, Beck HP, Canon J, Chen A, Chow D, Duquette J, Eksterowicz J, Fox BM, Fu J, Huang X, Houze J, Jin L, Li Y, Ling Y, Lo MC, Long AM, McGee LR, McIntosh J, Oliner JD, Osgood T, Rew Y, Saiki AY, Shaffer P, Wortman S, Yakowec P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Olson SH, Sun D, Medina JC.

J Med Chem · journal article · DOI 10.1021/jm401911v

Bibliografisk träff 2014-02-05

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.

Sun D, Li Z, Rew Y, Gribble M, Bartberger MD, Beck HP, Canon J, Chen A, Chen X, Chow D, Deignan J, Duquette J, Eksterowicz J, Fisher B, Fox BM, Fu J, Gonzalez AZ, Gonzalez-Lopez De Turiso F, Houze JB, Huang X, Jiang M, Jin L, Kayser F, Liu JJ, Lo MC, Long AM, Lucas B, McGee LR, McIntosh J, Mihalic J, Oliner JD, Osgood T, Peterson ML, Roveto P, Saiki AY, Shaffer P, Toteva M, Wang Y, Wang YC, Wortman S, Yakowec P, Yan X, Ye Q, Yu D, Yu M, Zhao X, Zhou J, Zhu J, Olson SH, Medina JC.

J Med Chem · journal article · DOI 10.1021/jm401753e

Bibliografisk träff 2013-07-16

Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development.

Ding Q, Zhang Z, Liu JJ, Jiang N, Zhang J, Ross TM, Chu XJ, Bartkovitz D, Podlaski F, Janson C, Tovar C, Filipovic ZM, Higgins B, Glenn K, Packman K, Vassilev LT, Graves B.

J Med Chem · journal article · DOI 10.1021/jm400487c

Bibliografisk träff 2013-05-24

Deconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor.

Fry DC, Wartchow C, Graves B, Janson C, Lukacs C, Kammlott U, Belunis C, Palme S, Klein C, Vu B.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml400062c

Bibliografisk träff 2013-04-02

Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.

Vu B, Wovkulich P, Pizzolato G, Lovey A, Ding Q, Jiang N, Liu JJ, Zhao C, Glenn K, Wen Y, Tovar C, Packman K, Vassilev L, Graves B.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml4000657