Recent advances and challenges of revolutionizing drug-resistant tuberculosis treatment.
Wei X, Yue L, Zhao B, Jiang N, Lei H, Zhai X.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2024.116785 PUBLIKATIONSREGISTRET
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J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.3c017032,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1.
Finger V, Kucera T, Kafkova R, Muckova L, Dolezal R, Kubes J, Novak M, Prchal L, Lakatos L, Andrs M, Hympanova M, Marek J, Kufa M, Spiwok V, Soukup O, Mezeiova E, Janousek J, Nevosadova L, Benkova M, Kitson RRA, Kratky M, Bősze S, Mikusova K, Hartkoorn R, Roh J, Korabecny J.
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Fernandes GFS, Thompson AM, Castagnolo D, Denny WA, Dos Santos JL.
J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.2c00227Scaffold Morphing To Identify Novel DprE1 Inhibitors with Antimycobacterial Activity.
R MM, Shandil R, Panda M, Sadler C, Ambady A, Panduga V, Kumar N, Mahadevaswamy J, Sreenivasaiah M, Narayan A, Guptha S, Sharma S, Sambandamurthy VK, Ramachandran V, Mallya M, Cooper C, Mdluli K, Butler S, Tommasi R, Iyer PS, Narayanan S, Chatterji M, Shirude PS.
ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.9b00343Synthesis and biological evaluation of 2,4,5-trisubstituted thiazoles as antituberculosis agents effective against drug-resistant tuberculosis.
Karale UB, Krishna VS, Krishna EV, Choudhari AS, Shukla M, Gaikwad VR, Mahizhaveni B, Chopra S, Misra S, Sarkar D, Sriram D, Dusthackeer VNA, Rode HB.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.05.082Decaprenylphosphoryl-β-d-ribose 2'-Epimerase 1 (DprE1): A Novel Therapeutic Target for the Treatment of Tuberculosis.
Abdel-Magid AF.
ACS Med Chem Lett · editorial; journal article · DOI 10.1021/acsmedchemlett.5b00080Lead optimization of 1,4-azaindoles as antimycobacterial agents.
Shirude PS, Shandil RK, Manjunatha MR, Sadler C, Panda M, Panduga V, Reddy J, Saralaya R, Nanduri R, Ambady A, Ravishankar S, Sambandamurthy VK, Humnabadkar V, Jena LK, Suresh RS, Srivastava A, Prabhakar KR, Whiteaker J, McLaughlin RE, Sharma S, Cooper CB, Mdluli K, Butler S, Iyer PS, Narayanan S, Chatterji M.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm500571fAzaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo.
Shirude PS, Shandil R, Sadler C, Naik M, Hosagrahara V, Hameed S, Shinde V, Bathula C, Humnabadkar V, Kumar N, Reddy J, Panduga V, Sharma S, Ambady A, Hegde N, Whiteaker J, McLaughlin RE, Gardner H, Madhavapeddi P, Ramachandran V, Kaur P, Narayan A, Guptha S, Awasthy D, Narayan C, Mahadevaswamy J, Vishwas KG, Ahuja V, Srivastava A, Prabhakar KR, Bharath S, Kale R, Ramaiah M, Choudhury NR, Sambandamurthy VK, Solapure S, Iyer PS, Narayanan S, Chatterji M.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm401382v