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Publikationer i urvalet

11 träffar

Bibliografisk träff 2023-04-26

Synthesis and biological evaluation of dual MDM2/XIAP inhibitors based on the tetrahydroquinoline scaffold.

Albadari N, Xie Y, Liu T, Wang R, Gu L, Zhou M, Wu Z, Li W.

Eur J Med Chem · research-article; journal article · DOI 10.1016/j.ejmech.2023.115423

Bibliografisk träff 2022-04-14

Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.

Zhang S, Yan Z, Li Y, Gong Y, Lyu X, Lou J, Zhang D, Meng X, Zhao Y.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.2c00095

Bibliografisk träff 2022-04-08

Small-molecule MDM2 inhibitors in clinical trials for cancer therapy.

Wang S, Chen FE.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2022.114334

Bibliografisk träff 2020-11-12

Evolution in non-peptide α-helix mimetics on the road to effective protein-protein interaction modulators.

Algar S, Martín-Martínez M, González-Muñiz R.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2020.113015

Bibliografisk träff 2020-07-19

Mdm2 inhibitors as a platform for the design of P-glycoprotein inhibitors.

Grigoreva T, Romanova A, Sagaidak A, Vorona S, Novikova D, Tribulovich V.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2020.127424

Bibliografisk träff 2019-05-17

Development of selective small molecule MDM2 degraders based on nutlin.

Wang B, Wu S, Liu J, Yang K, Xie H, Tang W.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.05.046

Bibliografisk träff 2018-09-18

The development of piperidinones as potent MDM2-P53 protein-protein interaction inhibitors for cancer therapy.

Liao G, Yang D, Ma L, Li W, Hu L, Zeng L, Wu P, Duan L, Liu Z.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2018.09.044

Bibliografisk träff 2018-04-18

Design, in silico prioritization and biological profiling of apoptosis-inducing lactams amenable by the Castagnoli-Cushman reaction.

Krasavin M, Gureyev MA, Dar'in D, Bakulina O, Chizhova M, Lepikhina A, Novikova D, Grigoreva T, Ivanov G, Zhumagalieva A, Garabadzhiu AV, Tribulovich VG.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2018.04.036

Bibliografisk träff 2014-12-04

Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.

Rew Y, Sun D, Yan X, Beck HP, Canon J, Chen A, Duquette J, Eksterowicz J, Fox BM, Fu J, Gonzalez AZ, Houze J, Huang X, Jiang M, Jin L, Li Y, Li Z, Ling Y, Lo MC, Long AM, McGee LR, McIntosh J, Oliner JD, Osgood T, Saiki AY, Shaffer P, Wang YC, Wortman S, Yakowec P, Ye Q, Yu D, Zhao X, Zhou J, Medina JC, Olson SH.

J Med Chem · journal article · DOI 10.1021/jm501550p

Bibliografisk träff 2014-03-27

Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.

Gonzalez AZ, Li Z, Beck HP, Canon J, Chen A, Chow D, Duquette J, Eksterowicz J, Fox BM, Fu J, Huang X, Houze J, Jin L, Li Y, Ling Y, Lo MC, Long AM, McGee LR, McIntosh J, Oliner JD, Osgood T, Rew Y, Saiki AY, Shaffer P, Wortman S, Yakowec P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Olson SH, Sun D, Medina JC.

J Med Chem · journal article · DOI 10.1021/jm401911v

Bibliografisk träff 2014-02-05

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.

Sun D, Li Z, Rew Y, Gribble M, Bartberger MD, Beck HP, Canon J, Chen A, Chen X, Chow D, Deignan J, Duquette J, Eksterowicz J, Fisher B, Fox BM, Fu J, Gonzalez AZ, Gonzalez-Lopez De Turiso F, Houze JB, Huang X, Jiang M, Jin L, Kayser F, Liu JJ, Lo MC, Long AM, Lucas B, McGee LR, McIntosh J, Mihalic J, Oliner JD, Osgood T, Peterson ML, Roveto P, Saiki AY, Shaffer P, Toteva M, Wang Y, Wang YC, Wortman S, Yakowec P, Yan X, Ye Q, Yu D, Yu M, Zhao X, Zhou J, Zhu J, Olson SH, Medina JC.

J Med Chem · journal article · DOI 10.1021/jm401753e