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Publikationer i urvalet

12 träffar

Bibliografisk träff 2022-09-05

Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity.

Wu X, Sun P, Chen X, Hua L, Cai H, Liu Z, Zhang C, Liang S, Chen Y, Wu D, Ou Y, Hu W, Yang Z.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.2c00523

Bibliografisk träff 2022-03-23

Broad-spectrum cyclic boronate β-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability.

Raja Reddy K, Totrov M, Lomovskaya O, Griffith DC, Tarazi Z, Clifton MC, Hecker SJ.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2022.116722

Bibliografisk träff 2021-07-31

High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.

Newman H, Krajnc A, Bellini D, Eyermann CJ, Boyle GA, Paterson NG, McAuley KE, Lesniak R, Gangar M, von Delft F, Brem J, Chibale K, Chibale K, Schofield CJ, Dowson CG.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.1c00717

Bibliografisk träff 2020-04-02

Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases.

Hecker SJ, Reddy KR, Lomovskaya O, Griffith DC, Rubio-Aparicio D, Nelson K, Tsivkovski R, Sun D, Sabet M, Tarazi Z, Parkinson J, Totrov M, Boyer SH, Glinka TW, Pemberton OA, Chen Y, Dudley MN.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.9b01976

Bibliografisk träff 2020-01-10

Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition.

Tooke CL, Hinchliffe P, Krajnc A, Mulholland AJ, Brem J, Schofield CJ, Spencer J.

RSC Med Chem · research-article; journal article · DOI 10.1039/c9md00557a

Bibliografisk träff 2019-12-16

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.

Liu B, Trout REL, Chu GH, McGarry D, Jackson RW, Hamrick JC, Daigle DM, Cusick SM, Pozzi C, De Luca F, Benvenuti M, Mangani S, Docquier JD, Weiss WJ, Pevear DC, Xerri L, Burns CJ.

J Med Chem · research support, non-u.s. gov't; research-article; news; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.9b01518

Bibliografisk träff 2019-09-16

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases.

Krajnc A, Brem J, Hinchliffe P, Calvopiña K, Panduwawala TD, Lang PA, Kamps JJAG, Tyrrell JM, Widlake E, Saward BG, Walsh TR, Spencer J, Schofield CJ.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.9b00911

Bibliografisk träff 2019-05-17

Profiling interactions of vaborbactam with metallo-β-lactamases.

Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J.

Bioorg Med Chem Lett · brief-report; research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2019.05.031

Bibliografisk träff 2018-08-17

β-lactam/β-lactamase inhibitor combinations: an update.

Tehrani KHME, Martin NI.

Medchemcomm · review-article; review; journal article · DOI 10.1039/c8md00342d

Bibliografisk träff 2017-06-20

Pharmaceutical Approaches to Target Antibiotic Resistance Mechanisms.

Schillaci D, Spanò V, Parrino B, Carbone A, Montalbano A, Barraja P, Diana P, Cirrincione G, Cascioferro S.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.7b00215

Bibliografisk träff 2015-03-17

Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.

Hecker SJ, Reddy KR, Totrov M, Hirst GC, Lomovskaya O, Griffith DC, King P, Tsivkovski R, Sun D, Sabet M, Tarazi Z, Clifton MC, Atkins K, Raymond A, Potts KT, Abendroth J, Boyer SH, Loutit JS, Morgan EE, Durso S, Dudley MN.

J Med Chem · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.5b00127

Bibliografisk träff 2014-06-26

Confronting the challenges of discovery of novel antibacterial agents.

Singh SB.

Bioorg Med Chem Lett · review; journal article · DOI 10.1016/j.bmcl.2014.06.053