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Publikationer i urvalet

9 träffar

Bibliografisk träff 2023-02-06

Synthesis and structure-activity optimization of 7-azaindoles containing aza-β-amino acids targeting the influenza PB2 subunit.

Wang S, Ying Z, Huang Y, Li Y, Hu M, Kang K, Wang H, Shao J, Wu G, Yu Y, Du Y, Chen W.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.115185

Bibliografisk träff 2022-02-25

Discovery of Aryl Benzoyl Hydrazide Derivatives as Novel Potent Broad-Spectrum Inhibitors of Influenza A Virus RNA-Dependent RNA Polymerase (RdRp).

Liu X, Liang J, Yu Y, Han X, Yu L, Chen F, Xu Z, Chen Q, Jin M, Dong C, Zhou HB, Lan K, Wu S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c01257

Bibliografisk träff 2022-01-19

Non-nucleoside structured compounds with antiviral activity-past 10 years (2010-2020).

Denel-Bobrowska M, Olejniczak AB.

Eur J Med Chem · review-article; review; journal article · DOI 10.1016/j.ejmech.2022.114136

Bibliografisk träff 2021-11-11

Identification of novel influenza polymerase PB2 inhibitors using virtual screening approach and molecular dynamics simulation analysis of active compounds.

Xu L, Zhao L, Che J, Zhang Q, Cao R, Li X.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2021.116515

Bibliografisk träff 2019-08-24

Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection.

Zhang H, Zhou L, Amichai S, Zandi K, Cox B, Schinazi R, Amblard F.

Bioorg Med Chem Lett · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2019.126639

Bibliografisk träff 2019-04-26

Discovery of 5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazin-2(1H)-one derivatives as new potent PB2 inhibitors.

Yang J, Du J, Huang C, Wang T, Huang L, Yang S, Li L.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2019.04.042

Bibliografisk träff 2018-11-10

Design, synthesis and biological evaluation of novel, orally bioavailable pyrimidine-fused heterocycles as influenza PB2 inhibitors.

Xiong J, Wang J, Hu G, Zhao W, Li J.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.11.015

Bibliografisk träff 2015-03-14

Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors.

Boyd MJ, Bandarage UK, Bennett H, Byrn RR, Davies I, Gu W, Jacobs M, Ledeboer MW, Ledford B, Leeman JR, Perola E, Wang T, Bennani Y, Clark MP, Charifson PS.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2015.03.013

Bibliografisk träff 2014-07-24

Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2.

Clark MP, Ledeboer MW, Davies I, Byrn RA, Jones SM, Perola E, Tsai A, Jacobs M, Nti-Addae K, Bandarage UK, Boyd MJ, Bethiel RS, Court JJ, Deng H, Duffy JP, Dorsch WA, Farmer LJ, Gao H, Gu W, Jackson K, Jacobs DH, Kennedy JM, Ledford B, Liang J, Maltais F, Murcko M, Wang T, Wannamaker MW, Bennett HB, Leeman JR, McNeil C, Taylor WP, Memmott C, Jiang M, Rijnbrand R, Bral C, Germann U, Nezami A, Zhang Y, Salituro FG, Bennani YL, Charifson PS.

J Med Chem · journal article · DOI 10.1021/jm5007275