Advancements in dual-target inhibitors of PI3K for tumor therapy: Clinical progress, development strategies, prospects.
Hu J, Fu S, Zhan Z, Zhang J.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2023.116109 PUBLIKATIONSREGISTRET
Gå till forskningen.
Publikationsdata från Europe PMC och PubMed. Följ källhänvisningar från ämnesregistret till originalpublikationerna.
Publikationer som ChEBI hänvisar till för vs-5584. Visa hela publikationsregistret
En publikationsträff är inte en slutsats. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.
Publikationer i urvalet
9 träffarDiscovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.
Takarada JE, Cunha MR, Almeida VM, Vasconcelos SNS, Santiago AS, Godoi PH, Salmazo A, Ramos PZ, Fala AM, de Souza LR, Da Silva IEP, Bengtson MH, Massirer KB, Couñago RM.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2023.117561Recent advances in PI3K/PKB/mTOR inhibitors as new anticancer agents.
Occhiuzzi MA, Lico G, Ioele G, De Luca M, Garofalo A, Grande F.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2022.114971Research progress of mTOR inhibitors.
Chen Y, Zhou X.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2020.112820Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases.
Bach J, Eastwood P, González J, Gómez E, Alonso JA, Fonquerna S, Lozoya E, Orellana A, Maldonado M, Calaf E, Albertí J, Pérez J, Andrés A, Prats N, Carreño C, Calama E, De Alba J, Calbet M, Miralpeix M, Ramis I.
J Med Chem · journal article · DOI 10.1021/acs.jmedchem.9b00533Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.
Chen D, Soh CK, Goh WH, Wang H.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.7b01465Design strategies, structure activity relationship and mechanistic insights for purines as kinase inhibitors.
Sharma S, Singh J, Ojha R, Singh H, Kaur M, Bedi PMS, Nepali K.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2016.02.018Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring.
Andrs M, Korabecny J, Jun D, Hodny Z, Bartek J, Kuca K.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm501026z2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors.
Cole AG, Bohnstedt AC, Paradkar V, Kingsbury C, Quintero JG, Park H, Lu Y, You M, Neagu I, Diller DJ, Letourneau JJ, Shao Y, James RA, Riviello CM, Ho KK, Lin TH, Wang B, Appell KC, Sills M, Quadros E, Kimble EF, Ohlmeyer MH, Webb ML.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.09.080