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Publikationer i urvalet

11 träffar

Bibliografisk träff 2023-12-20

Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.

Takarada JE, Cunha MR, Almeida VM, Vasconcelos SNS, Santiago AS, Godoi PH, Salmazo A, Ramos PZ, Fala AM, de Souza LR, Da Silva IEP, Bengtson MH, Massirer KB, Couñago RM.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2023.117561

Bibliografisk träff 2022-12-18

Targeted AURKA degradation: Towards new therapeutic agents for neuroblastoma.

Rishfi M, Krols S, Martens F, Bekaert SL, Sanders E, Eggermont A, De Vloed F, Goulding JR, Risseeuw M, Molenaar J, De Wilde B, Van Calenbergh S, Durinck K.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.115033

Bibliografisk träff 2021-10-05

Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile.

Sestito S, Bacci A, Chiarugi S, Runfola M, Gado F, Margheritis E, Gul S, Riveiro ME, Vazquez R, Huguet S, Manera C, Rezai K, Garau G, Rapposelli S.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113895

Bibliografisk träff 2021-03-10

Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells.

Dominici C, Sgarioto N, Yu Z, Sesma-Sanz L, Masson JY, Richard S, Raynal NJ.

Clin Epigenetics · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/s13148-021-01037-1

Bibliografisk träff 2019-11-11

Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization.

Allegretti PA, Horton TM, Abdolazimi Y, Moeller HP, Yeh B, Caffet M, Michel G, Smith M, Annes JP.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2019.115193

Bibliografisk träff 2017-12-01

The target landscape of clinical kinase drugs.

Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Depaolini SR, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, Tõnisson N, Kramer K, Götze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, Médard G, Jeremias I, Spiekermann K, Kuster B.

Science · research support, non-u.s. gov't; research-article; journal article · DOI 10.1126/science.aan4368

Bibliografisk träff 2017-08-24

A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies.

Borisa AC, Bhatt HG.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2017.08.045

Bibliografisk träff 2016-08-16

Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design.

Chang CF, Lin WH, Ke YY, Lin YS, Wang WC, Chen CH, Kuo PC, Hsu JTA, Uang BJ, Hsieh HP.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.08.026

Bibliografisk träff 2016-07-20

Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening.

Kilchmann F, Marcaida MJ, Kotak S, Schick T, Boss SD, Awale M, Gönczy P, Reymond JL.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.6b00709

Bibliografisk träff 2016-05-07

Design and synthesis of novel benzoxazole analogs as Aurora B kinase inhibitors.

An Y, Lee E, Yu Y, Yun J, Lee MY, Kang JS, Kim WY, Jeon R.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2016.05.017

Bibliografisk träff 2015-05-30

Fluorescent photoaffinity probes for mitotic protein kinase Aurora A.

Lavogina D, Kisand K, Raidaru G, Uri A.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2015.05.060